Expanding waistline linked to an increased risk of cancer

Conclusion This study provides more evidence of the link between excess body fat and 10 cancers. Though the percentage increases sound large, it's important to put these results into context. For example, the baseline risk of postmenopausal cancer was 2.2% – it occurred in 555 of the 24,751 women in the study. For women who hadn't used hormone therapy, this would increase to a risk of 2.7% if they had a BMI of 30 compared with 26, or a waist circumference of 95cm compared with 84cm. This accounts for only an extra 5 cases in every 1,000 women. This large study involved older adults from European countries, so the results should be applicable to people in the UK. Its strengths also include the fact researchers analysed data for each individual rather than relying on published results from each study, which could have used different definitions and cut-offs. As ever, though, there are some limitations to be aware of: There were differences between the cohorts, such as length of follow-up and age at entry into the study. Other medical conditions and medication weren't included in the analysis. Diet wasn't taken into account. Though the researchers looked at smoking, physical activity, and alcohol, they weren't able to analyse the results for different amounts of each. The obesity-related cancers were combined in the analysis because of small numbers, so we don't know if there was variation in risk between them. The length of follow-up may not have been...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print
Source: Journal of Pediatric Endocrinology and Metabolism - Category: Endocrinology Source Type: research
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Source: MedPage Today Public Health - Category: American Health Source Type: news
CONCLUSION: Additional counseling by nurses over the telephone does not increase the participation rate. Approaching patients who have CRC is an opportunity to increase the participation of their first-degree relatives in screening colonoscopy. The frequency of neoplasia that was found in this study underscores the need to screen relatives even before they reach the usual age threshold for screening. PMID: 30518470 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
Authors: Lee HH, Lee BI Abstract From dye-assisted conventional chromoendoscopy to novel virtual chromoendoscopy, image-enhanced endoscopy (IEE) is continuously evolving to meet clinical needs and improve the quality of colonoscopy. Dye-assisted chromoendoscopy using indigo carmine or crystal violet, although slightly old-fashioned, is still useful to emphasize the pit patterns of the colonic mucosa and predict the histological structures of relevant lesions. Equipment-based virtual chromoendoscopy has the advantage of being relatively easy to use. There are several types of virtual chromoendoscopy that vary depend...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
Conclusionsthe anti-obesity effect of liraglutide occurs through adaptive thermogenesis and may act through different cell signaling pathways in fat and skeletal muscle tissue. Liraglutide induces beige fat development partially through the AMPK-SIRT-1-PGC1- α cell signaling pathway. Therefore, liraglutide is a potential medication for obesity prevention and in targeting pre-diabetics.
Source: Endocrine - Category: Endocrinology Source Type: research
In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway. This was evident as altered gene expression in the mammary glands of key players in this pathway. Further functional analysis of the mice revealed elevated PTH levels, reduced Cyp27b1 expression in kidneys, and reduced trabecular bone volume/ tissue volume percentage. Plasma 25(OH)D and serum calcium were unchanged. This impairment was a result of genetic differences and oc...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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Source: Journal of Catalysis - Category: Chemistry Source Type: research
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Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
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