Expanding waistline linked to an increased risk of cancer

Conclusion This study provides more evidence of the link between excess body fat and 10 cancers. Though the percentage increases sound large, it's important to put these results into context. For example, the baseline risk of postmenopausal cancer was 2.2% – it occurred in 555 of the 24,751 women in the study. For women who hadn't used hormone therapy, this would increase to a risk of 2.7% if they had a BMI of 30 compared with 26, or a waist circumference of 95cm compared with 84cm. This accounts for only an extra 5 cases in every 1,000 women. This large study involved older adults from European countries, so the results should be applicable to people in the UK. Its strengths also include the fact researchers analysed data for each individual rather than relying on published results from each study, which could have used different definitions and cut-offs. As ever, though, there are some limitations to be aware of: There were differences between the cohorts, such as length of follow-up and age at entry into the study. Other medical conditions and medication weren't included in the analysis. Diet wasn't taken into account. Though the researchers looked at smoking, physical activity, and alcohol, they weren't able to analyse the results for different amounts of each. The obesity-related cancers were combined in the analysis because of small numbers, so we don't know if there was variation in risk between them. The length of follow-up may not have been...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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Publication date: 15 October 2018Source: Biosensors and Bioelectronics, Volume 117Author(s): Ahmed Y. El-Moghazy, Cunyi Zhao, Georges Istamboulie, Noha Amaly, Yang Si, Thierry Noguer, Gang SunAbstractAn ultrasensitive label-free amperometric immunosensor for the detection of chloramphenicol (CAP) residues in milk has been developed by using a screen-printed carbon electrode laminated with a layer of poly (vinyl alcohol-co-ethylene) (PVA-co-PE) nanofibrous membrane that is covalently immobilized with a CAP antibody (anti-CAP). The performance of the PVA-co-PE nanofiber membrane (PVA-co-PE NFM) on the electrode was compared ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Molecular BiologyAuthor(s): Michela Miani, Bernat Elvira, Esteban N. GurzovAbstractDiabetes is a metabolic disorder affecting more than 400 million individuals and their families worldwide. The major forms of diabetes (type 1 and 2) are characterized by pancreatic β-cell dysfunction and, in some cases, loss of β-cell mass causing hyperglycemia due to absolute or relative insulin deficiency. The BCL-2 homology 3 (BH3)-only protein BIM has a wide role in apoptosis induction in cells. In this review, we describe the apoptotic mechanisms mediated by BI...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
ConclusionThese results suggest that STAT3 and ReB constitute a minimal activator complex for positive regulation of MMP-1 in colon cancer
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 21 July 2018Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Karolina SapoĊ„, Teresa Janas, Aleksander F. Sikorski, Tadeusz JanasAbstractPolysialic acid (polySia) forms linear chains which are usually attached to the external surface of the plasma membrane mainly through the Neural Cell Adhesion Molecule (NCAM) protein. It is exposed on neural cells, several types of cancer cells, dendritic cells, and egg and sperm cells. There are several lipid raft-related phenomena in which polySia is involved; however the mechanisms of polySia action as well as determinants of its ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research
In this study, the hollow structure of MOF-5 was synthesized. Its drug loading and drug release capacity were studied. The human ovarian cancer SK-OV-3 cell line was selected to study the drug loading system, cytotoxicity, and cellular uptake. We concluded that a hollow MOF with an excellent morphology was successfully fabricated in the experiment; it increased the drug loading capacity, achieved a more ideal sustained-release effect, improved the treatment efficiency of the hydrophobic Chinese medicine component, and provided a relatively efficient drug loading material.Graphical abstract
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
Publication date: Available online 21 July 2018Source: Chinese Chemical LettersAuthor(s): Tianying Yuan, Dan Gao, Shangfu Li, Yuyang JiangAbstractRecapitulating the tumor microenvironment is a major challenge in the development of in vitro tumor model for the study of cancer biology and therapeutic treatments. 3D multicellular tumor spheroids (MCTS) have been used as reliable models of mimicking in vivo solid tumors. Macrophages and extracellular matrix (ECM), regarded as two key factors of the tumor microenvironment, play significant roles in tumor progression and drug resistance. In order to investigate their effects on ...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
ConclusionsRetrograde release of the neurovascular bundle with preservation of dorsal venous complex during RARP is safe and associated with excellent oncological and functional outcomes. Future comparative studies are needed.Patient summaryRobot-assisted radical prostatectomy (RARP) presents consistent oncological outcomes for prostate cancer; yet continence and potency results are not uniform. We present a technical modification for RARP aiming to preserve the nerves and vascular structures anterior to the prostate. We evaluated 128 consecutive patients with clinically localized or locally advanced prostate cancer underg...
Source: European Urology - Category: Urology & Nephrology Source Type: research
CONCLUSIONLECS as palliative treatment may be a viable option for high-risk patients with advanced gastric cancer.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 21 July 2018Source: Journal of Science and Medicine in SportAuthor(s): Samantha M. McDonald, Jihong Liu, Sara Wilcox, Xuemei Sui, Russell R. PateAbstractObjectivesMaternal body mass index (BMI) is a significant determinant of infant macrosomia. Given the strong metabolic effects of physical activity (PA), independent of body mass, it is unclear as to whether maternal PA may affect the risk of delivering a macrosomic infant. Thus, the purpose of this study was to determine if maternal PA moderates the relationship between maternal BMI and infant macrosomia.DesignCross-sectional study using...
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Publication date: Available online 21 July 2018Source: Social Science &MedicineAuthor(s): Alexandra RodneyAbstractIn this paper, I investigate the contribution of healthy living blogs to discourse about healthy eating, seeking to understand how blogs compare to mass-media magazine sources. This is done by comparatively analysing 459 healthy living blog posts and 141 health and fitness magazine articles. These were collected between 2011 and 2013 and provide rich data about what food content looks like in media designed for an audience of American women. I analyze how each source establishes the purpose of healthy eatin...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
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