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Expanding waistline linked to an increased risk of cancer

Conclusion This study provides more evidence of the link between excess body fat and 10 cancers. Though the percentage increases sound large, it's important to put these results into context. For example, the baseline risk of postmenopausal cancer was 2.2% – it occurred in 555 of the 24,751 women in the study. For women who hadn't used hormone therapy, this would increase to a risk of 2.7% if they had a BMI of 30 compared with 26, or a waist circumference of 95cm compared with 84cm. This accounts for only an extra 5 cases in every 1,000 women. This large study involved older adults from European countries, so the results should be applicable to people in the UK. Its strengths also include the fact researchers analysed data for each individual rather than relying on published results from each study, which could have used different definitions and cut-offs. As ever, though, there are some limitations to be aware of: There were differences between the cohorts, such as length of follow-up and age at entry into the study. Other medical conditions and medication weren't included in the analysis. Diet wasn't taken into account. Though the researchers looked at smoking, physical activity, and alcohol, they weren't able to analyse the results for different amounts of each. The obesity-related cancers were combined in the analysis because of small numbers, so we don't know if there was variation in risk between them. The length of follow-up may not have been...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Obesity Source Type: news

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Source: Future Medicine: Biomarkers in Medicine - Category: Internal Medicine Tags: Biomark Med Source Type: research
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Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
Authors: Tucci M, Leone G, Buttigliero C, Zichi C, DI Stefano RF, Pignataro D, Vignani F, Scagliotti GV, DI Maio M Abstract Androgen deprivation therapy (ADT) is the mainstay of treatment of patients with relapsed or metastatic hormone-sensitive prostatic carcinoma. The dramatic reduction of serum testosterone levels induced by ADT produces multiple side effects as vasomotor flushing, sexual dysfunction, fatigue, impairment of cognitive function, reduced quality of sleep, gynecomastia and anemia, that are able to decrease health-related quality of life (QoL). In addition, hormonal therapy can interfere with bone me...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
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Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
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Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
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Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
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Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
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Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
CONCLUSIONS: Locally advanced rectal cancers require multidisciplinary management including neoadjuvant chemo-radiotherapy and surgery. Preoperative re-staging may be useful to plan the best surgical procedure. Minimally invasive surgery, especially laparoscopy, can provide adequate outcomes in selected patients with locally advanced rectal cancer with the advantage of faster recovery compared to open surgery. However, the overall evidence is poor, and further studies are needed to elucidate the role of minimally invasive surgery for cT4 rectal cancer. PMID: 29243454 [PubMed - as supplied by publisher]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
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Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
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