Vitamin D and human health: evidence from Mendelian randomization studies
AbstractWe summarized the current evidence on vitamin D and major health outcomes from Mendelian randomization (MR) studies. PubMed and Embase were searched for original MR studies on vitamin D in relation to any health outcome from inception to September 1, 2022. Nonlinear MR findings were excluded due to concerns about the validity of the statistical methods used. A meta-analysis was preformed to synthesize study-specific estimates after excluding overlapping samples, where applicable. The methodological quality of the included studies was evaluated according to the STROBE-MR checklist. A total of 133 MR publications were eligible for inclusion in the analyses. The causal association between vitamin D status and 275 individual outcomes was examined. Linear MR analyses showed genetically high 25-hydroxyvitamin D (25(OH)D) concentrations were associated with reduced risk of multiple sclerosis incidence and relapse, non-infectious uveitis and scleritis, psoriasis, femur fracture, leg fracture, amyotrophic lateral sclerosis, anorexia nervosa, delirium, heart failure, ovarian cancer, non-alcoholic fatty liver disease, dyslipidemia, and bacterial pneumonia, but increased risk of Beh çet's disease, Graves' disease, kidney stone disease, fracture of radium/ulna, basal cell carcinoma, and overall cataracts. Stratified analyses showed that the inverse association between genetically predisposed 25(OH)D concentrations and multiple sclerosis risk was significant and consistent regar d...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
More News: Alcoholism | ALS | Anorexia | Bacterial Pneumonia | Basal Cell Carcinoma | Cancer | Cancer & Oncology | Carcinoma | Cardiology | Cataracts | Eating Disorders & Weight Management | Epidemiology | Fatty Liver Disease (FLD) | Genetics | Heart | Heart Failure | Hepatocellular Carcinoma | Kidney Stones | Liver | Liver Cancer | Liver Disease | Men | Multiple Sclerosis | Non-alcoholic Fatty Liver Diseases (NAFLD) | Ovarian Cancer | Ovaries | Pneumonia | Psoriasis | Skin Cancer | Statistics | Study | Urology & Nephrology | Vitamin D | Vitamins