Calorie Restriction as a Treatment to Slow Parkinson ' s Disease

Calorie restriction is known to suppress inflammation to some degree, alongside many other benefits to health that result from the reaction of cells and biological systems to a reduced calorie intake. Since chronic inflammation in brain tissue is implicated in the onset and development of neurodegenerative conditions, this makes calorie restriction a topic of interest in this part of the field. With a few exceptions, that interest largely manifests as research aimed at reproducing some of the metabolic alterations of calorie restriction with small molecule drugs, however, rather than more more rigorously testing calorie restriction as a therapy. Parkinson's disease (PD) is the second most common neurodegenerative disease. To date, PD is still incurable and its pathogenesis remains elusive. Evidence from experimental studies reveals that mechanisms including protein misfolding and aggregation, neuroinflammation, mitochondrial dysfunction, and altered gut bacteria composition contribute to PD development. As of now, a number of medication strategies have been widely applied to control the motor and non-motor symptoms of PD and improve the quality of life. However, with long-term application of these drugs and as the disease progresses, adverse effects emerge. Moreover, these medications could neither effectively prevent the disease onset nor stop the disease progression. Recently, lifestyle interventions in the promotion of healthy brain aging and the prevention and tr...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs