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Total 493674 results found since Jan 2013.
Integrated network pharmacology and metabolomics analyses of the mechanism underlying the efficacy of Ma-Mu-Ran Antidiarrheal Capsules against dextran sulfate sodium-induced ulcerative colitis
In this study, we established a mouse model of UC using dextran sulfate sodium. Colonic tissues were collected from mice and then subjected to hematoxylin and eosin staining, as well as histopathological analysis, to assess the therapeutic effect of MMRAC. Furthermore, we assessed the mechanisms through which MMRAC combats UC by employing integrated metabolomics and network pharmacology strategies. Lastly, we validated the key targets identified through western blot and molecular docking. An integrated network of metabolomics and network pharmacology was constructed using Cytoscape to identify eight endogenous metabolites ...
Source: Biomedical Chromatography : BMC - September 21, 2023 Category: Biomedical Science Authors: Hailing Huang Bailu Duan Sili Zheng Yan Ye Dongning Zhang Zhuang Huang Shanshan Wang Fengyun Zhang Ping Huang Fang Huang Lintao Han Source Type: research
Food Insecurity, Telomere Length and the Potential Modifying Effects of Social Support in NHANES
CONCLUSION: Food insecurity is modestly associated with shorter TL. Contrary to our hypothesis, food insecurity had more deleterious effects on TL among participants with high social support than low social support. Results may indicate that the food insecure population is a higher needs population, and increased social support reflects these needs rather than providing protective effects.PMID:37734859 | DOI:10.1017/S1368980023002008
Source: Public Health Nutrition - September 21, 2023 Category: International Medicine & Public Health Authors: Sarah M Lima Xuefeng Ren Lina Mu Heather M Ochs-Balcom Tia Palermo Source Type: research
Oral mucosal disease recognition based on dynamic self-attention and feature discriminant loss
CONCLUSIONS: Convolutional neural networks can effectively capture the visual features of the oral mucosal disease lesions, and the distinguished visual features of different oral lesions can be extracted better using dynamic self-attention and feature discrimination loss function, which is conducive to the auxiliary diagnosis of oral mucosal diseases.PMID:37731172 | DOI:10.1111/odi.14732
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Fei Xie Pengfei Xu Xinyi Xi Xiaokang Gu Panpan Zhang Hexu Wang Xuemin Shen Source Type: research
Network-supported and adaptable binding efficacy for flexible and multi-functionalized chitosan/phenolic carbaldehyde hydrogels
Int J Biol Macromol. 2023 Sep 19:127004. doi: 10.1016/j.ijbiomac.2023.127004. Online ahead of print.ABSTRACTA thoughtful strategy has been intended to control the hydrogel networking to assess the binding efficacy of multifunctional hydrogel. The processing of two distinct network-supported hydrogels has portrayed to express the operating interactions involved during co-existence with solvents, small molecules, biomolecules, etc. Herein, chitosan has separately functionalized in semisynthetic approaches with 4-hydroxyisopthalaldehyde (ChDA) and 2-hydroxybenzene-1,3,5-tricarbaldehyde (ChTA) to construct different gel networ...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Shubhankar Ghorai Biswajit Jana Jhuma Ganguly Source Type: research
Hemicelluloses hydrogel: Synthesis, characterization, and application in dye removal
Int J Biol Macromol. 2023 Sep 19:127010. doi: 10.1016/j.ijbiomac.2023.127010. Online ahead of print.ABSTRACTNovel materials using biowaste as adsorbents in wastewater treatment have been allocated considerable interest. Herein, we present the synthesis of different hydrogels of crosslinked polyacrylamide in presence of hemicelluloses with/ without bentonite, using a soft reaction condition. The structure of new hydrogels was characterized by spectroscopic, thermal and microscopic experiments. The semi-interpenetrated network with hemicelluloses: 10 %; acrylamide 79 %; bentonite 10 %; N,N,N',N'-tetramethylethylenediamine: 1...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: C A Rodr íguez-Ramírez Joana E Tasqu é Nancy Lis Garcia Norma B D'Accorso Source Type: research
The Role of lncRNA-miR-26a-mRNA Network in Cancer Progression and Treatment
Biochem Genet. 2023 Sep 20. doi: 10.1007/s10528-023-10475-w. Online ahead of print.ABSTRACTThe role of non-coding RNAs in regulating biological processes associated with cancer progression, such as proliferation, migration, and apoptosis, has been extensively studied. Long non-coding RNAs (lncRNAs) play a role in regulating these processes through various mechanisms, including transcriptional and post-transcriptional modifications. In post-transcriptional regulation, lncRNAs can bind to specific miRNAs and affect their function, which can either promote or inhibit cancer development. The interaction between lncRNAs, miRNAs...
Source: Biochemical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Jun Zhu Liya Wang Source Type: research
The Significance of Hematuria in Podocytopathies
CONCLUSIONS: Hematuria is prevalent among participants with the three podocytopathies and is significantly and independently associated with worse kidney-related outcomes, including both progressive loss of kidney function remission of proteinuria.PMID:37733352 | DOI:10.2215/CJN.0000000000000309
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 21, 2023 Category: Urology & Nephrology Authors: Dorota Marchel Howard Trachtman Maria Larkina Margaret Helmuth Jennifer Y Lai Yee Damian Fermin Andrew S Bomback Pietro A Canetta Debbie S Gipson Amy K Mottl Rulan S Parekh Manish K Saha Matthew G Sampson Richard A Lafayette Laura H Mariani Nephrotic Synd Source Type: research
Improved daily estimates of relative humidity at high resolution across Germany: A random forest approach
Environ Res. 2023 Sep 19:117173. doi: 10.1016/j.envres.2023.117173. Online ahead of print.ABSTRACTThe lack of readily available methods for estimating high-resolution near-surface relative humidity (RH) and the incapability of weather stations to fully capture the spatiotemporal variability can lead to exposure misclassification in studies of environmental epidemiology. We therefore aimed to predict German-wide 1 × 1 km daily mean RH during 2000-2021. RH observations, longitude and latitude, modelled air temperature, precipitation and wind speed as well as remote sensing information on topographic elevation, vegetation, a...
Source: Environmental Research - September 21, 2023 Category: Environmental Health Authors: Nikolaos Nikolaou Laurens M Bouwer Marco Dallavalle Mahyar Valizadeh Massimo Stafoggia Annette Peters Kathrin Wolf Alexandra Schneider Source Type: research
Network pharmacology and molecular docking to scientifically validate the potential mechanism of Lonicerae japonicae flos in the clinical treatment of COVID-19
Nat Prod Res. 2023 Sep 21:1-8. doi: 10.1080/14786419.2023.2260070. Online ahead of print.ABSTRACTUsing network pharmacology and molecular docking, we predicted the potential mechanisms of Lonicerae japonicae flos (LJF) therapy for COVID-19. A total of 493 component-related targets and 6,233 COVID-19-related genes were identified, and 267 core genes with overlapping of the two types of genes were identified. The target AKT1, CASP3, IL1B, IL6, PTGS2, TNF and JUN were the hub genes in PPI network according to MCODE score. Component-Target analysis showed the close relationship between targets and components. The results of fu...
Source: Natural Product Research - September 21, 2023 Category: Biochemistry Authors: Yisheng Huang Yan Fang Huanhuan Jie Hongbiao Yang Wen Zhou Yijian Chen Baolin Zhong Source Type: research
Generalized morality culturally evolves as an adaptive heuristic in large social networks
J Pers Soc Psychol. 2023 Sep 21. doi: 10.1037/pspa0000358. Online ahead of print.ABSTRACTWhy do people assume that a generous person should also be honest? Why do we even use words like "moral" and "immoral"? We explore these questions with a new model of how people perceive moral character. We propose that people vary in the extent to which they perceive moral character as "localized" (varying along many contextually embedded dimensions) versus "generalized" (varying along a single dimension from morally bad to morally good). This variation might be partly the product of cultural evolutionary adaptations to different kind...
Source: Journal of Personality and Social Psychology - September 21, 2023 Category: Psychiatry & Psychology Authors: Joshua Conrad Jackson Jamin Halberstadt Masanori Takezawa Kongmeng Liew Kristopher Smith Coren Apicella Kurt Gray Source Type: research
STARGATE-X: a Python package for statistical analysis on the REACTOME network
J Integr Bioinform. 2023 Sep 21. doi: 10.1515/jib-2022-0029. Online ahead of print.ABSTRACTMany important aspects of biological knowledge at the molecular level can be represented by pathways. Through their analysis, we gain mechanistic insights and interpret lists of interesting genes from experiments (usually omics and functional genomic experiments). As a result, pathways play a central role in the development of bioinformatics methods and tools for computing predictions from known molecular-level mechanisms. Qualitative as well as quantitative knowledge about pathways can be effectively represented through biochemical ...
Source: Journal of integrative bioinformatics - September 21, 2023 Category: Bioinformatics Authors: Andrea Marino Blerina Sinaimeri Enrico Tronci Tiziana Calamoneri Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
Comparative efficacy of pulmonary surfactant in respiratory distress syndrome in preterm infants: a Bayesian network meta-analysis
CONCLUSIONS: Compared with beractant, other pulmonary surfactants are more effective to reduce the mortality of respiratory distress syndrome in preterm infants. Surfactant A drugs appeared to have the best efficacy in reducing mortality of respiratory distress syndrome in preterm infants.PMID:37732036 | PMC:PMC10507746 | DOI:10.5114/aoms.2020.97065
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Caihong Qiu Cui Ma Nana Fan Xiaoyu Zhang Guofeng Zheng Source Type: research
Development of a Maternal Equity Safety Bundle to Eliminate Racial Inequities in Massachusetts
CONCLUSION: Structure, process, and outcome quality measures were selected and defined for a maternal equity safety bundle that seeks to create an equity-focused infrastructure and equity-specific actions at birthing facilities. Implementation of an equity-focused safety bundle at birthing facilities may close racial gaps in maternal outcomes.PMID:37734090 | DOI:10.1097/AOG.0000000000005322
Source: Obstetrics and Gynecology - September 21, 2023 Category: OBGYN Authors: Anna Kheyfets Kali Vitek Claire Conklin Christianna Tu Elysia Larson Chloe Zera Ronald Iverson Emily Reiff Andrew Healy Julianne Lauring Corina Schoen Karen Manganaro Mary Pomerleau Bonnell Glass Ndidiamaka Amutah-Onukagha Hafsatou Diop Audra R Meadows Source Type: research
Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia
This report summarizes the workshop and highlights selected presentations.PMID:37731161 | DOI:10.1007/s12192-023-01383-4
Source: Cell Stress and Chaperones - September 21, 2023 Category: Cytology Authors: Christian M ünch Janine Kirstein Source Type: research
