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Total 493674 results found since Jan 2013.
Influence of research evidence on the use of cardiovascular clinical prediction rules in primary care: an exploratory qualitative interview study
CONCLUSIONS: Clinicians' perceptions and experiences could influence how they use research evidence in decisions about using cardiovascular CPRs. This implies, when promoting evidence-based decisions, it might be useful to target clinicians' unfamiliarity, distrust, and challenges regarding the use of research evidence rather than focusing only on their knowledge and skills. Further, because clinicians often rely on evidence-unrelated factors, guideline developers and policymakers should recommend cardiovascular CPRs supported by high-quality evidence.PMID:37730553 | DOI:10.1186/s12875-023-02155-w
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Jong- Wook Ban Rafael Perera Veronika Williams Source Type: research
Exposure to ambient air pollutants, serum miRNA networks, lipid metabolism, and non-alcoholic fatty liver disease in young adults
CONCLUSIONS: Exposure to AAP may contribute to adverse lipid profiles and NAFLD risk among young adults via altered expression of microRNA profiles.PMID:37729806 | DOI:10.1016/j.ecoenv.2023.115486
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: William B Patterson Elizabeth Holzhausen Bridget Chalifour Jesse Goodrich Elizabeth Costello Frederick Lurmann David V Conti Zhanghua Chen Lida Chatzi Tanya L Alderete Source Type: research
A New Strategy for Rejuvenating Primary Healthcare: The Government-Society Partnership Model
J Prim Care Community Health. 2023 Jan-Dec;14:21501319231200763. doi: 10.1177/21501319231200763.ABSTRACTPrimary healthcare systems worldwide are under stress as increased demands during pandemic surges have exposed deficiencies in the system. Primary healthcare centers have significant responsibilities but are often underfunded and understaffed. Recent events, including the COVID-19 pandemic, have highlighted the importance of a strong primary health center network to promote community health and save lives. Most governments have multiple competing financial needs for scarce resources, ultimately limiting the advancement o...
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Siddarth S Kasi Source Type: research
Prediction of groundwater quality index to assess suitability for drinking purpose using averaged neural network and geospatial analysis
This study revealed that over 50 % of the evaluated wells (Total 8326 wells) were inappropriate as sources of drinking water, indicating a pressing need for policy revision. The averaged neural network model achieved a high predictive accuracy of approximately 95 % for GQI grades, outperforming other classification models. The introduction of 2D spatial analysis in conjunction with machine learning algorithms notably increased the predictive accuracy for unevenly distributed groundwater samples. Moreover, this combined approach enabled the intuitive visualization of groundwater vulnerability across various regions, which c...
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: Seok Hyun Ahn Do Hwan Jeong MoonSu Kim Tae Kwon Lee Hyun-Koo Kim Source Type: research
Insight into the effect of particulate organic matter on sludge granulation at the low organic load: Sludge characteristics, extracellular polymeric substances and microbial communities response
Bioresour Technol. 2023 Sep 18:129791. doi: 10.1016/j.biortech.2023.129791. Online ahead of print.ABSTRACTThis paper investigated the effect of particulate organic matter (POM) on sludge granulation under low organic load. The results showed that POM promoted the formation of aerobic granular sludge (AGS) with a chemical oxygen demand (COD) fraction of 25%, and POM also enhanced the sludge settleability and biomass retention. However, when the COD fraction of POM increased to 50% and 75%, the AGS performance deteriorated. The analysis of extracellular polymeric substances revealed that the POM (accounted for ≤ 50% of COD...
Source: Bioresource Technology - September 20, 2023 Category: Biotechnology Authors: Zhe Liu Rushuo Yang Dan Zhang Jiaxuan Wang Min Gao Aining Zhang Wenlong Liu Yongjun Liu Source Type: research
Single-cell RNA sequencing atlas of peripheral blood mononuclear cells from subjects with coronary artery disease
CONCLUSIONS: Our study offered a detailed profiling of single-cell RNA sequencing of PBMCs from subjects with CADs and controls. These data provide a line of evidence that the JUN signaling pathway may be a potential diagnostic and therapeutic molecule target for CAD.PMID:37730128 | DOI:10.1016/j.bbamcr.2023.119593
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Xiaolong Song Yahong Fu Chengcheng Li Qiaowei Jia Mengmeng Ren Xin Zhang Hengjie Bie Hanxiao Zhou Xiongkang Gan Shu He Yanjun Wang Sheng Zhang Renyou Pan Weixin Sun Haitang Zhou Qimeng Ni Jun Song Qian Zhang Xiumei Chen Enzhi Jia Source Type: research
Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
Biosci Rep. 2023 Sep 20:BSR20222591. doi: 10.1042/BSR20222591. Online ahead of print.ABSTRACTDNA replication forks are subject to intricate surveillance and strict regulation by sophisticated cellular machinery. Such close regulation is necessary to ensure the accurate duplication of genetic information and to tackle the diverse endogenous and exogenous stresses that impede this process. Stalled replication forks are vulnerable to collapse, which is a major cause of genomic instability and carcinogenesis. Replication stress responses, which are organized via a series of coordinated molecular events, stabilize stalled repli...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Donghui Xia Xuefei Zhu Ying Wang Peng Gong Hong-Shu Su Xingzhi Xu Source Type: research
Preparation of magnetic sodium alginate/sodium carboxymethylcellulose interpenetrating network gel spheres and use in superefficient adsorption of direct dyes in water
Int J Biol Macromol. 2023 Sep 18:126985. doi: 10.1016/j.ijbiomac.2023.126985. Online ahead of print.ABSTRACTThe rapid development of the printing and dyeing industry has led to the production of a large amount of high-density printing and dyeing wastewater, and technology for its effective treatment has become a focus of research. To construct a polymeric adsorbent material with abundant functional groups for the efficient adsorption of dye wastewater, a novel magnetic sodium alginate/carboxymethylcellulose interpenetrating network gel sphere (Fe3O4@SA/CMC-Fe) was prepared by co-blending sodium alginate (SA) and sodium car...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Chen Chen Enhui He Weina Jia Shuwei Xia Liangmin Yu Source Type: research
Xanthan and gum acacia modified olive oil based nanoemulsion as a controlled delivery vehicle for topical formulations
In this study, olive oil nanoemulsion modified with xanthan gum and gum acacia was explored as a potential controlled topical delivery vehicle. Oil-in-water nanoemulsion formulated with optimized composition of olive oil, tween 80, and water was used as the drug carrier and further modified with gum. Effect of gum on nanoemulsion different physiochemical characteristics, stability, rheology, drug release and encapsulation efficiency were investigated. Results showed that developed nanoemulsion behaved as low viscosity Newtonian fluid and released 100 % drug within 6 h. Modification with xanthan and gum acacia had significa...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Khadijatul Kobra Siew Yee Wong Mohammad A Jafar Mazumder Xu Li M Tarik Arafat Source Type: research
In-depth insight into the effects of tapioca or corn acetylated distarch phosphate on the gel properties and in vitro digestibility of kung-wan
This study aimed to investigate the effects of incorporating tapioca acetylated distarch phosphate (TADSP) or corn acetylated distarch phosphate (CADSP) on the gel properties and in vitro digestibility of Chinese-style meatballs known as kung-wan. The results showed that TADSP and CADSP significantly enhanced the textural properties of kung-wan in a dose-dependent manner (P < 0.05), as well as enhanced the rheological behavior of meat batters. TADSP resulted in a denser meat protein gel network compared to CADSP, primarily because the lower pasting temperature of TADSP made it gelatinize earlier and more completely duri...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Sumeng Wei Xue Liang Yining Xu Baohua Kong Xin Li Hongwei Zhang Qian Liu Hui Wang Source Type: research
Exploring associations between built environment and crash risk of children in school commuting
Accid Anal Prev. 2023 Sep 18;193:107287. doi: 10.1016/j.aap.2023.107287. Online ahead of print.ABSTRACTUnderstanding how built environment are associated with crash risk (CR) in school commuting is essential to improving travel safety through land use and transportation policies. Scholars often assume that this relationship is consistent across space, but this may lead to inconsistent estimates. To address this issue, using data in Shenzhen, China, the data covers traffic accident data of children taken from police incident reports and supplemented with local land use, transportation network and specific school information...
Source: Accident; Analysis and Prevention. - September 20, 2023 Category: Accident Prevention Authors: Yaxin Wu Xiaowei Hu Xiaofeng Ji Ke Wu Source Type: research
Performance patterns of primary health care in the face of COVID-19 in Brazil: characteristics and contrasts
This study aims to contrast two extreme standards of PHC performance in the fight against COVID-19 in Brazil, comparing them with the profiles of the corresponding municipalities and characteristics of the organization of services. Based on the results of a cross-sectional national survey with a representative sample of UBSs, we created a synthetic index to evaluate how PHC performs against COVID-19 called CPI, composed of axes of health surveillance and social support (collective dimension) and of COVID-19 care and continuity of care (individual dimension). Of the 907 surveyed UBSs, 120 were selected, half of which had th...
Source: Cadernos de Saude Publica - September 20, 2023 Category: International Medicine & Public Health Authors: Simone Schenkman Aylene Emilia Moraes Bousquat Luiz Augusto Facchini C élia Regina Rodrigues Gil L ígia Giovanella Source Type: research
Can network infrastructure construction improve the low-carbon innovation of Chinese enterprises?
This study considers the implementation of the "Broadband China" strategy as an exogenous policy shock and examines the impact of network infrastructure construction (NIC) on the low-carbon innovation (LCI) of enterprises and its underlying mechanisms by using a progressive difference-in-difference model based on the data of Chinese listed enterprises from 2009 to 2020. This study finds that NIC can improve the LCI of enterprises. After the elimination of the sample selection bias and selection of the urban slope as the exogenous instrumental variable, the conclusions remained robust. The results of the mechanism test show...
Source: Environmental Science and Pollution Research International - September 20, 2023 Category: Environmental Health Authors: Haikuo Zhang Yuankun Li Source Type: research
Cleavage furrow-directed cortical flows bias PAR polarization pathways to link cell polarity to cell division
Curr Biol. 2023 Sep 15:S0960-9822(23)01155-7. doi: 10.1016/j.cub.2023.08.076. Online ahead of print.ABSTRACTDuring development, the conserved PAR polarity network is continuously redeployed, requiring that it adapt to changing cellular contexts and environmental cues. In the early C. elegans embryo, polarity shifts from being a cell-autonomous process in the zygote to one that must be coordinated between neighbors as the embryo becomes multicellular. Here, we sought to explore how the PAR network adapts to this shift in the highly tractable C. elegans germline P lineage. We find that although P lineage blastomeres exhibit ...
Source: Current Biology - September 20, 2023 Category: Biology Authors: KangBo Ng Nisha Hirani Tom Bland Joana Borrego-Pinto Susan Wagner Moritz Kreysing Nathan W Goehring Source Type: research
A food interaction network between psittacines and plants in an urban area in the city of S ão Carlos - SP, southeastern Brazil
Braz J Biol. 2023 Sep 15;83:e269353. doi: 10.1590/1519-6984.269353. eCollection 2023.ABSTRACTThe Psittacidae presents a great diversity of species in the Neotropical region performing fundamental ecological functions for ecosystems. These frugivorous birds can occupy different positions in the antagonistic-mutualistic gradient of food interactions, acting as predators and/or as seed dispersers. Little is known about bird-plant ecological interaction networks focusing on psittacines in urban environments, which may compromise the management of natural areas in anthropic landscapes and hinder the planning of conservation str...
Source: Braz J Biol - September 20, 2023 Category: Biology Authors: A M Leoni M G Reis M M Dias Filho Source Type: research
