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Carbapenem-Resistant Klebsiella pneumoniae in Large Public Acute-Care Healthcare System, New York, New York, USA, 2016-2022
Emerg Infect Dis. 2023 Oct;29(10):1973-1978. doi: 10.3201/eid2910.230153.ABSTRACTControlling the spread of carbapenem-resistant Enterobacterales is a global priority. Using National Healthcare Safety Network data, we characterized the changing epidemiology of carbapenem-resistant Klebsiella pneumoniae (CRKP) in a large public health system in New York, New York, USA. During 2016-2020, CRKP cases declined; however, during 2021-June 2022, a notable increase occurred. Of 509 cases, 262 (51%) were considered community-onset, including 149 in patients who were living at home. Of 182 isolates with proven or presumptive (ceftazid...
Source: Emerging Infectious Diseases - September 22, 2023 Category: Infectious Diseases Authors: Jennifer Lee Subin Sunny Elizabeth Nazarian Mary Fornek Marie Abdallah Briana Episcopia Marie-Claire Rowlinson John Quale Source Type: research
Fragmentation of Care in Patients with Peritoneal Metastases Undergoing Cytoreductive Surgery
CONCLUSIONS: There were no significant differences in survival or SAEs based on the networks of systemic therapy delivery. This suggests that patients undergoing CRS at a high-volume center may safely receive systemic therapy at outside-network facilities with comparable outcomes.PMID:37737968 | DOI:10.1245/s10434-023-14318-1
Source: Ann Oncol - September 22, 2023 Category: Cancer & Oncology Authors: Mason Vierra Varun V Bansal Ryan B Morgan Hunter D D Witmer Biren Reddy Ankit Dhiman Frederick A Godley Cecilia T Ong Erika Belmont Blas é Polite Ardaman Shergill Kiran K Turaga Oliver S Eng Source Type: research
Behavioral Health Integrated Support Network (BHISN)
CONCLUSION: The Virtual Medical Center-Europe, Army Europe Behavioral Health, and Substance Use leadership work collaboratively to plan and optimize program performance. For BHISN to function as intended requires key dedicated support staff, such as mental health and social services assistants to screen and coordinate virtual care. Scheduling can be performed by a central cell requiring clinics to relinquish some local control in the interest of meeting patient demand in large and diverse area that covers three continents. BHISN shows promising initial success by providing a process of managing demand and connecting reques...
Source: Military Medicine - September 22, 2023 Category: International Medicine & Public Health Authors: Steven M Cain Sara Bennetts Gage Riddoch Damon Pratt Audra Stock Veronica Isidron Maria Lopez Matthew Orchowsky Source Type: research
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Cell Mol Neurobiol. 2023 Sep 22. doi: 10.1007/s10571-023-01405-w. Online ahead of print.ABSTRACTTo study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard database: 1. Perception of sound (PoS), 2. Acoustic stimulation (AcouStim), and 3. Tinnitus (Tin). Enrichment analysis by the DAVID database resulted in similar Gene Ontology (GO) terms for cellular components in all gene lists, reflecting synaptic structures known to be involved in auditory processing. The STRING protein-protein interaction (PPI) network and the Cytoscape data an...
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Johann Gross Marlies Knipper Birgit Mazurek Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
Cold polypectomy techniques for small and diminutive colorectal polyps: a systematic review and network meta-analysis of randomized controlled trials
CONCLUSION: CFP is the least effective method for small and diminutive polyps' removal, and any snare polypectomy technique will achieve better results, warranting more large-scale RCTs to investigate the most effective snare polypectomy technique.PMID:37735986 | DOI:10.1080/03007995.2023.2262374
Source: Current Medical Research and Opinion - September 22, 2023 Category: Research Authors: Mohamed Abuelazm Ahmed K Awad Islam Mohamed Abdelrahman Mahmoud Hosam Shaikhkhalil Nour Shaheen Omar Abdelwahab Ahmed M Afifi Basel Abdelazeem Mohamed O Othman Source Type: research
Relationship of personality, psychological distress, and substance use with social network characteristics of college going young adults
CONCLUSION: Personality and psychological distress are associated with an individual's social network and significantly contribute to student substance use problems.PMID:37736229 | PMC:PMC10510637 | DOI:10.4103/indianjpsychiatry.indianjpsychiatry_182_23
Source: Indian Journal of Psychiatry - September 22, 2023 Category: Psychiatry Authors: P C Pradeep Kumar Sojan Antony Pratima Murthy Ammapattian Thirumoorthy Mariamma Philip Source Type: research
Modeling unveils sex differences of signaling networks in mouse embryonic stem cells
Mol Syst Biol. 2023 Sep 21:e11510. doi: 10.15252/msb.202211510. Online ahead of print.ABSTRACTFor a short period during early development of mammalian embryos, both X chromosomes in females are active, before dosage compensation is ensured through X-chromosome inactivation. In female mouse embryonic stem cells (mESCs), which carry two active X chromosomes, increased X-dosage affects cell signaling and impairs differentiation. The underlying mechanisms, however, remain poorly understood. To dissect X-dosage effects on the signaling network in mESCs, we combine systematic perturbation experiments with mathematical modeling. ...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Zeba Sultana Mathurin Dorel Bertram Klinger Anja Sieber Ilona Dunkel Nils Bl üthgen Edda G Schulz Source Type: research
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
Nat Struct Mol Biol. 2023 Sep 21. doi: 10.1038/s41594-023-01105-5. Online ahead of print.ABSTRACTSubstrate polyubiquitination drives a myriad of cellular processes, including the cell cycle, apoptosis and immune responses. Polyubiquitination is highly dynamic, and obtaining mechanistic insight has thus far required artificially trapped structures to stabilize specific steps along the enzymatic process. So far, how any ubiquitin ligase builds a proteasomal degradation signal, which is canonically regarded as four or more ubiquitins, remains unclear. Here we present time-resolved cryogenic electron microscopy studies of the ...
Source: Mol Biol Cell - September 22, 2023 Category: Molecular Biology Authors: Tatyana Bodrug Kaeli A Welsh Derek L Bolhuis Ethan Paul аkonis Raquel C Martinez-Chacin Bei Liu Nicholas Pinkin Thomas Bonacci Liying Cui Pengning Xu Olivia Roscow Sascha Josef Amann Irina Grishkovskaya Michael J Emanuele Joseph S Harrison Joshua P Steim Source Type: research
Network Analysis of Health-related Behaviors, Insomnia, and Depression Among Urban Left-behind Adolescents in China
This study aims to examine the symptom level associations among multiple health-related behaviors, insomnia, and depression in urban LBA. Data on a sample of urban LBA aged 11-19 (N = 3,601) from the Adolescent Mental Health Survey in Shenzhen, China, were used. Health-related behaviors (i.e., Internet use, physical inactivity, social jetlag, smoking, and alcohol consumption), insomnia, and depressive symptoms were assessed using a self-administered questionnaire. Graphical Gaussian Model (GGM) was used to describe key bridging nodes in an undirected network. Directed Acyclic Graph (DAG) was used to construct a directed ne...
Source: Child Psychiatry and Human Development - September 22, 2023 Category: Child Development Authors: Yifan Zhang Zijuan Ma Wanyi Chen Dongfang Wang Fang Fan Source Type: research
Personalized Immunotherapy of Patients: Defining by Single-cell RNA-seq with Artificial Intelligence
Med Res Arch. 2023 Aug;11(8):10.18103/mra.v11i8.4293. doi: 10.18103/mra.v11i8.4293. Epub 2023 Aug 30.ABSTRACTImmunotherapy, including immune cell therapy and targeted therapy, is gradually developed through the ongoing discovery of molecular compounds or immune cells. Choosing the best one or the best combination of target compounds and immune-cell therapy is a challenge for clinical scientists and clinicians. We have found variable efficacy individually after tumor-infiltrating lymphocyte (TIL) therapy, and now TILs have been discovered in a group of heterogeneous immune cells. To select the best immunotherapy for each pa...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Biaoru Li Source Type: research
Mechanism and kinetics investigation of reaction network: 1,3 ‐Dichloro‐2‐propanol with alkali to prepare epichlorohydrin
AbstractDehydrochlorination of 1,3-dichloropropanol with alkali is a key step to industrially produce epichlorohydrin. But there are many side reactions involved in the synthesis process. In this work, a complete mechanism and kinetics investigation of the related reaction network was constructed. Density functional theory simulation method was first used to simulate the possible reactions so as to confirm the reaction mechanism and simplify the reaction network. Based on the simulation results, the complex reaction network was simplified into a three-step consecutive reaction. The kinetic parameters of the three consecuti...
Source: AIChE Journal - September 22, 2023 Category: Science Authors: Liang ‐Liang Zhang,
Yi‐Dong Zhang,
Wen‐Jing Zhu,
Xin‐Tuo Chen,
Guang‐Wen Chu,
Jian‐Feng Chen Tags: RESEARCH ARTICLE Source Type: research
Does advanced imaging guide therapy
I’m a PMR/spine specialist and was curious if MRIs help you all when treating chronic neck and/ or low back pain? If so can you give specific examples of how it would guide your treatment plan in both the neck and low back.
Appreciate all that you do
Source: Student Doctor Network - September 22, 2023 Category: Universities & Medical Training Authors: clubdeac Tags: Physical Therapy Source Type: forums
Mitigation of the parallel-path effect for reliable monitoring of a passive optical network using standard optical time domain reflectometry
Optical access networks evolve towards higher bit-rates, which is driven by a growing number of fiber-to-the-home users and by ...
Source: Journal of Optical Communications and Networking - September 22, 2023 Category: Physics Authors: Patryk J. Urban Source Type: research
WAMC ORM 3.8 cGPA 520 MCAT (+Big Red Flag)
Hello! I recently graduated and plan to apply next cycle. I would greatly appreciate any advice regarding my school list, application, and in general. As the title describes, I was convicted of a DUI misdemeanor about a year ago. Thankfully, nobody was hurt. I deeply regret that selfish and reckless night, and I have made a lot of changes to make sure I never let anything of that nature happen again. I plan to have this expunged in a few months, but I will be transparent about the incident...
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Source: Student Doctor Network - September 22, 2023 Category: Universities & Medical Training Authors: bun209 Tags: What Are My Chances? WAMC Medical Source Type: forums
