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Total 493674 results found since Jan 2013.
Translated article Implementation of the standardized process of drug therapy evaluation in inpatients and outpatients
CONCLUSIONS: This study shows a clinical pharmacist developed tool called SPEP that increased the pharmacist evaluation and pharmacist interventions number in multiple clinical scenarios. These were significant only in critical care patients. Future investigations should make effort to evaluate the quality and clinical impact of these interventions.PMID:37735005 | DOI:10.1016/j.farma.2023.06.003
Source: Farmacia Hospitalaria - September 21, 2023 Category: Drugs & Pharmacology Authors: A Gonz ález W Guti érrez T Fuenzalida F Lizana M Guti érrez N Severino Source Type: research
Graph Attention Network based mapping of knowledge relations between chemical spaces of Nuclear factor kappa B and Centella asiatica
This study aims to explore the regulatory nature of the molecules from the inhibition and activation of the NF-κB bioassay data set and map this information for a knowledge-based analysis against the molecules of CA, a low-growing tropical plant. This finding has led to a new direction in the field, transitioning from the conventional active-inactive framework to a more comprehensive active-inactive-regulatory model. This approach can be thoroughly explored by leveraging a graph-based deep learning system. The study presents an innovative approach using a Graph Attention Network (GAT) to rank CA molecules in chemical spac...
Source: Computational Biology and Chemistry - September 21, 2023 Category: Bioinformatics Authors: Vivek P Mithun Mohanan Shajil U K Sandesh E Pa Jaleel U C A Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: Biomedical Science Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
Predicting Factors for Blood Transfusion in Primary Total Knee Arthroplasty Using a Machine Learning Method
CONCLUSION: This study demonstrated that MPNN for the prediction of patient-specific blood transfusion rates after TKA represented a novel application of machine learning with the potential to improve preoperative planning for treatment outcomes.PMID:37733328 | DOI:10.5435/JAAOS-D-23-00063
Source: The Journal of the American Academy of Orthopaedic Surgeons - September 21, 2023 Category: Orthopaedics Authors: Daniel R Cavazos Zain Sayeed Tannor Court Chaoyang Chen Bryan E Little Hussein F Darwiche Source Type: research
Tough, recyclable and biocompatible carrageenan-modified polyvinyl alcohol ionic hydrogel with physical cross-linked for multimodal sensing
Int J Biol Macromol. 2023 Sep 19:126954. doi: 10.1016/j.ijbiomac.2023.126954. Online ahead of print.ABSTRACTBiocompatibility hydrogel conductors are considered as sustainable bio-electronic materials for the application of wearable sensors and implantable devices. However, they mostly face the limitations of mismatched mechanical properties with skin tissue and the difficulty of recycling. In this regard, here, a biocompatible, tough, reusable sensor based on physical crosslinked polyvinyl alcohol (PVA) ionic hydrogel modified with ι-carrageenan (ι-CG) helical network was reported. Through simulating the ion transport an...
Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Lingjun Zeng Bo Liu Lijie Duan Guanghui Gao Source Type: research
Protein quality control: from molecular mechanisms to therapeutic intervention-EMBO workshop, May 21-26 2023, Srebreno, Croatia
This report summarizes the workshop and highlights selected presentations.PMID:37731161 | DOI:10.1007/s12192-023-01383-4
Source: Cell Stress and Chaperones - September 21, 2023 Category: Cytology Authors: Christian M ünch Janine Kirstein Source Type: research
A Novel Scoring Model of Deubiquitination Patterns Predicts Prognosis and Immunotherapeutic Response in Hepatocellular Carcinoma
In conclusion, our study revealed the crucial role of deubiquitination patterns in shaping TME complexity and diversity. A more personalized and effective antitumour immunotherapy strategy can be developed by utilizing the DUBscore model to identify deubiquitination patterns in individual HCC patients. Our findings also highlight that BRCC3 may serve as a potential therapeutic target in HCC and a predictive marker for immunotherapeutic response.PMID:37734237 | DOI:10.1016/j.tranon.2023.101789
Source: Translational Oncology - September 21, 2023 Category: Cancer & Oncology Authors: Jiahao Zhang Gefeng Wu Rui Peng Jun Cao Daoyuan Tu Jie Zhou Bingbing Su Shengjie Jin Guoqing Jiang Chi Zhang Dousheng Bai Source Type: research
Carbon-Based Electron Buffer Layer on ZnOx-Fe5C2-Fe3O4 Boosts Ethanol Synthesis from CO2 Hydrogenation
Angew Chem Int Ed Engl. 2023 Sep 21:e202311786. doi: 10.1002/anie.202311786. Online ahead of print.ABSTRACTThe conversion of CO2 into ethanol with renewable H2 has attracted tremendous attention due to its integrated functions of carbon elimination and chemical synthesis, but still being challenging. The electronic property of catalyst is essential to determine the adsorption strength and configuration of the key intermediates, therefore altering the reaction network for targeted synthesis. Here, a carbon buffer layer is employed to tailor the electronic property of the ternary ZnOx-Fe5C2-Fe3O4, in which the electron trans...
Source: Angewandte Chemie - September 21, 2023 Category: Chemistry Authors: Yang Wang Wenhang Wang Ruosong He Meng Li Jinqiang Zhang Fengliang Cao Jianxin Liu Shiyuan Lin Xinhua Gao Guohui Yang Mingqing Wang Tao Xing Tao Liu Qiang Liu Han Hu Noritatsu Tsubaki Mingbo Wu Source Type: research
STARGATE-X: a Python package for statistical analysis on the REACTOME network
J Integr Bioinform. 2023 Sep 21. doi: 10.1515/jib-2022-0029. Online ahead of print.ABSTRACTMany important aspects of biological knowledge at the molecular level can be represented by pathways. Through their analysis, we gain mechanistic insights and interpret lists of interesting genes from experiments (usually omics and functional genomic experiments). As a result, pathways play a central role in the development of bioinformatics methods and tools for computing predictions from known molecular-level mechanisms. Qualitative as well as quantitative knowledge about pathways can be effectively represented through biochemical ...
Source: Journal of integrative bioinformatics - September 21, 2023 Category: Bioinformatics Authors: Andrea Marino Blerina Sinaimeri Enrico Tronci Tiziana Calamoneri Source Type: research
Antifragile, sustainable, and agile supply chain network design by considering resiliency, robustness, risk, and environmental requirements
Environ Sci Pollut Res Int. 2023 Sep 20. doi: 10.1007/s11356-023-29488-4. Online ahead of print.ABSTRACTThis research suggests an Antifragile, Sustainable and Agile Supply Chain Network Design (ASASCND) as a new network design that integrates these concepts considering resiliency, robustness, risk, and environmental requirements. The cost function combines a novel method with robust stochastic optimization and Entropic Value at Risk (EVaR). This model combines expected value, maximum and EVaR of cost as an objective function. This research adds antifragility by the effect of learning on variable parameters, sustainability ...
Source: Environmental Science and Pollution Research International - September 21, 2023 Category: Environmental Health Authors: Reza Lotfi Mojtaba Sadreddini Mehrjardi Pedram Mohajer Ansari Farshid Zolfaqari Mohamad Afshar Source Type: research
D-pinitol ameliorated H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans
In this study, we intended to explore the anti-aging mechanism of DP, utilizing computer modeling techniques. The results demonstrated that DP significantly delayed H2O2-induced cellular senescence. Model PC12 cells treated with DP exhibited increased cell viability, increased antioxidant enzyme activity (SOD, CAT), and reduced ROS and MDA levels. Furthermore, DP was discovered to have a positive effect on healthy longevity. In C. elegans, DP treatment enhanced lifespan, stress capacity, antioxidant capacity (T-SOD/CAT/GSH-Px/MDA/ROS), and altered aging-related indicators of lipofuscin accumulation, pharyngeal pump rate, m...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 21, 2023 Category: Biochemistry Authors: Miaosi Zhang Zhe Xu Liangyong Shao Jilite Wang Zouyan He Yumei Jiang Ye Zhang Hao Wang Source Type: research
Preventive effects of 13 different drugs on colorectal cancer: a network meta-analysis
CONCLUSIONS: The preventive effect of allopurinol on CRC was better than that of the other 13 drugs. These results can help doctors and patients understand the preventative effects of these drugs more intuitively and provide an evidence-based basis for the clinical application of these drugs.PMID:37732038 | PMC:PMC10507769 | DOI:10.5114/aoms/167480
Source: Archives of Medical Science - September 21, 2023 Category: General Medicine Authors: Qi Fu Huini Liao Zhihao Li Xing Chen Xuan Zhang Ji Di Source Type: research
The NEF-SPA Approach as a Framework for Developing a Neurobiologically Inspired Spiking Neural Network Model for Speech Production
CONCLUSIONS: The model presented here is a promising approach for describing speech processing in a bottom-up manner based on a set of micro-circuit neural network elements for generating a large-scale neural network. In addition, the model conforms to a top-down design, as it is available in a condensed form in box-and-arrow models based on functional imaging and electrophysiological data recruited from speech processing tasks.PMID:37735137 | DOI:10.31083/j.jin2205124
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Bernd J Kr öger Source Type: research
Derailment of Sleep Homeostatic Plasticity Affects the Most Plastic Brain Systems and Carries the Risk of Epilepsy
J Integr Neurosci. 2023 Aug 9;22(5):111. doi: 10.31083/j.jin2205111.ABSTRACTAlthough a critical link between non-rapid eye movement (NREM) sleep and epilepsy has long been suspected, the interconnecting mechanisms have remained obscure. However, recent advances in sleep research have provided some clues. Sleep homeostatic plasticity is now recognized as an engine of the synaptic economy and a feature of the brain's ability to adapt to changing demands. This allows epilepsy to be understood as a cost of brain plasticity. On the one hand, plasticity is a force for development, but on the other it opens the possibility of epi...
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Peter Hal ász Igor Timofeev Anna Sz űcs Source Type: research
Artesunate Sensitizes Human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy
In conclusion, artesunate may be a promising strategy to mitigate sorafenib resistance in HCC via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy.PMID:37733919 | DOI:10.1080/15548627.2023.2261758
Source: Autophagy - September 21, 2023 Category: Cytology Authors: Zhaochen Ma Wenjia Chen Yudong Liu Lingxiang Yu Xia Mao Xiaodong Guo Funeng Jiang Qiuyan Guo Na Lin Yanqiong Zhang Source Type: research
