A Novel Scoring Model of Deubiquitination Patterns Predicts Prognosis and Immunotherapeutic Response in Hepatocellular Carcinoma

In conclusion, our study revealed the crucial role of deubiquitination patterns in shaping TME complexity and diversity. A more personalized and effective antitumour immunotherapy strategy can be developed by utilizing the DUBscore model to identify deubiquitination patterns in individual HCC patients. Our findings also highlight that BRCC3 may serve as a potential therapeutic target in HCC and a predictive marker for immunotherapeutic response.PMID:37734237 | DOI:10.1016/j.tranon.2023.101789

Source: Translational Oncology - September 21, 2023 Category: Cancer & Oncology Authors: Jiahao Zhang Gefeng Wu Rui Peng Jun Cao Daoyuan Tu Jie Zhou Bingbing Su Shengjie Jin Guoqing Jiang Chi Zhang Dousheng Bai Source Type: research