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Network Analysis Reveals Unique Associations of Mindfulness and Distress with Immunity in M āori and Non-Māori New Zealanders
ConclusionsThese findings suggest that anxiety is strongly linked to poor immunity across both M āori and non-Māori in New Zealand while networks of mindfulness and distress also demonstrated differences unique for each of these groups. Both similarities and differences between Māori and non-Māori should be considered when developing targeted interventions to improve physical and mental hea lth in New Zealand.PreregistrationThis study is not preregistered.
Source: Mindfulness - September 21, 2023 Category: Psychiatry & Psychology Source Type: research
The minimum number of examined lymph nodes was 24 for optimal survival of pathological T2-4 gastric cancer: a multi-center, hospital-based study covering 20 years of data
The current National Comprehensive Cancer Network (NCCN) guidelines recommend that at least 16 lymph nodes should be examined for gastric cancer patients to reduce staging migration. However, there is still de...
Source: BMC Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Lulu Zhao, Fan Zhang, Fuzhi Jiao, Xiadong Zhou, Penghui Niu, Xue Han, Wanqing Wang, Xiaoyi Luan, Mingyan He, Quanlin Guan, Yumin Li, Dongbing Zhao, Jidong Gao and Yingtai Chen Tags: Research Source Type: research
Targeting the microenvironment in the treatment of arteriovenous malformations
AbstractExtracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain, bleeding, relentless growth, and high volume of shunted blood. Due to the high vascular pressure endothelial cells of AVMs are exposed to mechanical stress. To control symptoms and lesion growth pharmacological treatment strategies are urgently needed in addition to surgery and interventional radiology. AVM cells were isolated from three patients and exposed to cyclic mechanical stretching for 24 h. Thalidomide and bevacizumab, both VEGF inhibitors, were tested for their ability to prevent th...
Source: Angiogenesis - September 21, 2023 Category: Molecular Biology Source Type: research
Social Network Dynamics in the Context of Age: An Empirical Investigation
AbstractThis paper explores patterns and motivations for social tie formation and dissolution in the context of age. It provides empirical tests of the social convoy model, socioemotional selectivity theory, and the differential investment of resources (DIRe) model. Data comes from a survey administered face-to-face to a large, representative sample of the population of Poland (n = 1000). Controlling for between-tie and between-ego differences, it is found that the intensity of forming and dropping new ties is a decreasing function of age, but the relationship becomes weaker among people aged 40 and older. The number o...
Source: Social Indicators Research - September 21, 2023 Category: International Medicine & Public Health Source Type: research
Targeting the microenvironment in the treatment of arteriovenous malformations
AbstractExtracranial arteriovenous malformations (AVMs) are regarded as rare diseases and are prone to complications such as pain, bleeding, relentless growth, and high volume of shunted blood. Due to the high vascular pressure endothelial cells of AVMs are exposed to mechanical stress. To control symptoms and lesion growth pharmacological treatment strategies are urgently needed in addition to surgery and interventional radiology. AVM cells were isolated from three patients and exposed to cyclic mechanical stretching for 24 h. Thalidomide and bevacizumab, both VEGF inhibitors, were tested for their ability to prevent th...
Source: Angiogenesis - September 21, 2023 Category: Molecular Biology Source Type: research
Deep neural network-estimated age using optical coherence tomography predicts mortality
AbstractThe concept of biological age has emerged as a measurement that reflects physiological and functional decline with ageing. Here we aimed to develop a deep neural network (DNN) model that predicts biological age from optical coherence tomography (OCT). A total of 84,753 high-quality OCT images from 53,159 individuals in the UK Biobank were included, among which 12,631 3D-OCT images from 8,541 participants without any reported medica l conditions at baseline were used to develop an age prediction model. For the remaining 44,618 participants, OCT age gap, the difference between the OCT-predicted age and chronologica...
Source: AGE - September 21, 2023 Category: Geriatrics Source Type: research
Expanding the phenotypic spectrum of TRAPPC11-related muscular dystrophy: 25 Roma individuals carrying a founder variant
Conclusion
We provide a comprehensive phenotypic characterisation of the pathogenic variant TRAPPC11 c.1287+5G>A, which is founder in the Roma population. Our observations indicate that some typical features of golgipathies, such as microcephaly and clinical decompensation associated with infections, are prevalent in individuals with LGMD R18.
Source: Journal of Medical Genetics - September 21, 2023 Category: Genetics & Stem Cells Authors: Justel, M., Jou, C., Sariego-Jamardo, A., Julia-Palacios, N. A., Ortez, C., Poch, M. L., Hedrera-Fernandez, A., Gomez-Martin, H., Codina, A., Dominguez-Carral, J., Muxart, J., Hernandez-Lain, A., Vila-Bedmar, S., Zulaica, M., Cancho-Candela, R., Castro, M Tags: Open access Genotype-phenotype correlations Source Type: research
Sensors, Vol. 23, Pages 8013: A New Dual-Input Deep Anomaly Detection Method for Early Faults Warning of Rolling Bearings
unkai Wei
To address the problem of low fault diagnosis accuracy caused by insufficient fault samples of rolling bearings, a dual-input deep anomaly detection method with zero fault samples is proposed for early fault warning of rolling bearings. First, the main framework of dual-input feature extraction based on a convolutional neural network (CNN) is established, and the two outputs of the main frame are subjected to the autoencoder structure. Then, the secondary feature extraction is performed. At the same time, the experience pool structure is introduced to improve the feature learning ability of the network. A new...
Source: Sensors - September 21, 2023 Category: Biotechnology Authors: Yuxiang Kang Guo Chen Hao Wang Wenping Pan Xunkai Wei Tags: Article Source Type: research
Sensors, Vol. 23, Pages 8014: Generative Adversarial Network (GAN)-Based Autonomous Penetration Testing for Web Applications
Zhao
The web application market has shown rapid growth in recent years. The expansion of Wireless Sensor Networks (WSNs) and the Internet of Things (IoT) has created new web-based communication and sensing frameworks. Current security research utilizes source code analysis and manual exploitation of web applications, to identify security vulnerabilities, such as Cross-Site Scripting (XSS) and SQL Injection, in these emerging fields. The attack samples generated as part of web application penetration testing on sensor networks can be easily blocked, using Web Application Firewalls (WAFs). In this research work, we prop...
Source: Sensors - September 21, 2023 Category: Biotechnology Authors: Ankur Chowdhary Kritshekhar Jha Ming Zhao Tags: Article Source Type: research
Bicc1 ribonucleoprotein complexes specifying organ laterality are licensed by ANKS6-induced structural remodeling of associated ANKS3
by Benjamin Roth é, Yayoi Ikawa, Zhidian Zhang, Takanobu A. Katoh, Eriko Kajikawa, Katsura Minegishi, Sai Xiaorei, Simon Fortier, Matteo Dal Peraro, Hiroshi Hamada, Daniel B. Constam
Organ laterality of vertebrates is specified by accelerated asymmetric decay ofDand5 mRNA mediated by Bicaudal-C1 (Bicc1) on the left side, but whether binding of this or any other mRNA to Bicc1 can be regulated is unknown. Here, we found that a CRISPR-engineered truncation in ankyrin and sterile alpha motif (SAM)-containing 3 (ANKS3) leads to symmetric mRNA decay mediated by the Bicc1-interactingDand5 3 ′ UTR. AlphaFold structure predicti...
Source: PLoS Biology: Archived Table of Contents - September 21, 2023 Category: Biology Authors: Benjamin Roth é Source Type: research
Network Analysis Reveals Unique Associations of Mindfulness and Distress with Immunity in M āori and Non-Māori New Zealanders
ConclusionsThese findings suggest that anxiety is strongly linked to poor immunity across both M āori and non-Māori in New Zealand while networks of mindfulness and distress also demonstrated differences unique for each of these groups. Both similarities and differences between Māori and non-Māori should be considered when developing targeted interventions to improve physical and mental hea lth in New Zealand.PreregistrationThis study is not preregistered.
Source: Mindfulness - September 21, 2023 Category: Psychiatry & Psychology Source Type: research
Guidance to develop a multidisciplinary, international, pediatric registry: a systematic review
The European Reference Network for craniofacial anomalies and ear, nose and throat disorders (ERN-CRANIO) aims to improve craniofacial care on a European scale. Within ERN-CRANIO, the cleft lip and palate (CL/...
Source: Orphanet Journal of Rare Diseases - September 21, 2023 Category: Internal Medicine Authors: S. Ombashi, P. A. J. van der Goes, S. L. Versnel, R. H. Khonsari and A. E. Mink van der Molen Tags: Review Source Type: research
Identification of disease-related genes in Plasmodium berghei by network module analysis
Plasmodium berghei has been used as a preferred model for studying human malaria, but only a limited number of disease-associated genes of P. berghei have been reported to date. Identification of new disease-rela...
Source: BMC Microbiology - September 21, 2023 Category: Microbiology Authors: Junhao Lin, Shan Zeng, Qiong Chen, Guanghui Liu, Suyue Pan and Xuewu Liu Tags: Research Source Type: research
Risk of COVID-19 in-hospital mortality in people living with HIV compared to general population according to age and CD4 strata: data from the Icona network
Since the early phase of SARS-CoV-2 pandemic it has been questioned which groups of subjects were at higher risk of worse COVID-19 outcomes. This would have allowed firstly to implement specific preventing interventions, allocate therapeutic resources, and in the later phases of the pandemic prioritize COVID-19 vaccination. Demographic factors shortly appeared to be the main determinants of COVID-19 outcomes, with older age, male sex and social deprivation as strongly associated with hospitalization and death [1].
Source: International Journal of Infectious Diseases - September 21, 2023 Category: Infectious Diseases Authors: Andrea Giacomelli, Roberta Gagliardini, Alessandro Tavelli, Sara De Benedittis, Valentina Mazzotta, Giuliano Rizzardini, Annalisa Mondi, Matteo Augello, Spinello Antinori, Alessandra Vergori, Andrea Gori, Marianna Menozzi, Lucia Taramasso, Francesco Maria Source Type: research
After Failed Bid to Reclaim Namesake Company, Ben ' Bitboy ' Armstrong Asks Fans for Cash
Ben "Bitboy" Armstrong, former host of the Bitboy Crypto YouTube channel, has been denied an emergency injunction request filed to the Cobb County Superior Court in Georgia as a part of his ongoing lawsuit against Hit Network CEO TJ Shedd and Shedd’s father, new documents filed this week revealed.…#benbitboyarmstrong #bitboycryptoyoutube #georgia #hitnetwork #shedd #cobbcountyclerks #timothysheddsr #cfo #lamborghini #ethereumandbitcoin
Source: Reuters: Health - September 20, 2023 Category: Consumer Health News Source Type: news
