Network-supported and adaptable binding efficacy for flexible and multi-functionalized chitosan/phenolic carbaldehyde hydrogels

Int J Biol Macromol. 2023 Sep 19:127004. doi: 10.1016/j.ijbiomac.2023.127004. Online ahead of print.ABSTRACTA thoughtful strategy has been intended to control the hydrogel networking to assess the binding efficacy of multifunctional hydrogel. The processing of two distinct network-supported hydrogels has portrayed to express the operating interactions involved during co-existence with solvents, small molecules, biomolecules, etc. Herein, chitosan has separately functionalized in semisynthetic approaches with 4-hydroxyisopthalaldehyde (ChDA) and 2-hydroxybenzene-1,3,5-tricarbaldehyde (ChTA) to construct different gel networks. The disposition of gel networks ChDA adapts more flexible chain or spine, whereas ChTA possesses restricted movements within gel networks. The gel networks of hydrogels have a significant role in their distinct physical activities. Their gel-bonding elucidations have performed to establish the variation in mechanical, swelling photophysical properties, etc. Remarkable self-fluorescence behaviors are used as a tool for binding study. Distinctive gel networks and their flexibility have investigated against self-fluorescence, UV-Vis, and FTIR against small molecule, Boron trifluoride and biomolecule, and Bovine serum albumin. Hydrogel/BF3 shows variation in fluorescence due to the disposition of gel networks. Hydrogel/BSA quenching of fluorescence at three different temperatures provides the binding constant and Stern-Volmer quenching constant. Theoretical ...

Source: International Journal of Biological Macromolecules - September 21, 2023 Category: Biochemistry Authors: Shubhankar Ghorai Biswajit Jana Jhuma Ganguly Source Type: research