Cholecystokinin-Induced Duodenogastric Bile Reflux Increases the Severity of Indomethacin-Induced Gastric Antral Ulcers in Re-fed Mice
ConclusionsThese results suggest that CCK-CCK1 receptor signal increases bile reflux during gastroparesis induced by atropine and dopamine, exacerbating IND-induced antral ulcers.Graphical Abstract (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - March 6, 2024 Category: Gastroenterology Source Type: research
Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway
Toxicol Appl Pharmacol. 2024 Mar 2:116875. doi: 10.1016/j.taap.2024.116875. Online ahead of print.ABSTRACTCisplatin is an effective and commonly used chemotherapeutic drug; however, its use is accompanied by several adverse effects, including chemobrain. Ondansetron is a 5-HT3 antagonist, commonly used in prophylactic against chemotherapy-induced nausea and vomiting. Moreover, it has been identified as a novel neuroprotective agent in different animal models. However, its protective role against chemotherapy-induced chemobrain has not been investigated. The current study was the first study that explored the potential neur...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Mennat-Allah M Hassan Sara A Wahdan Reem N El-Naga Tamer M Abdelghany Ebtehal El-Demerdash Source Type: research
Ondansetron attenuates cisplatin-induced behavioral and cognitive impairment through downregulation of NOD-like receptor inflammasome pathway
Toxicol Appl Pharmacol. 2024 Mar 2:116875. doi: 10.1016/j.taap.2024.116875. Online ahead of print.ABSTRACTCisplatin is an effective and commonly used chemotherapeutic drug; however, its use is accompanied by several adverse effects, including chemobrain. Ondansetron is a 5-HT3 antagonist, commonly used in prophylactic against chemotherapy-induced nausea and vomiting. Moreover, it has been identified as a novel neuroprotective agent in different animal models. However, its protective role against chemotherapy-induced chemobrain has not been investigated. The current study was the first study that explored the potential neur...
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Mennat-Allah M Hassan Sara A Wahdan Reem N El-Naga Tamer M Abdelghany Ebtehal El-Demerdash Source Type: research
Comparison of prophylaxis strategy for postoperative nausea and vomiting and its incidence before and after the implementation of 5-hydroxytryptamine 3 in surgical setting: a single-center, retrospective study
ConclusionThe availability of ondansetron increased the number of patients with adequate PONV prophylaxis, but did not decrease the incidence of PONV. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - March 4, 2024 Category: Anesthesiology Source Type: research
The impact of Aprepitant on Nausea and Vomiting following Laparoscopic Sleeve Gastrectomy: A Blinded Randomized Controlled Trial
ConclusionsProphylactic aprepitant improved PONV between 0 h (early) and 24 h postoperatively in patients undergoing LSG.Graphical Abstract (Source: Obesity Surgery)
Source: Obesity Surgery - March 2, 2024 Category: Surgery Source Type: research
The Management of Nausea and Vomiting in Pregnancy and Hyperemesis Gravidarum (Green-top Guideline No. 69)
BJOG. 2024 Feb 4. doi: 10.1111/1471-0528.17739. Online ahead of print.ABSTRACTAn objective and validated index of nausea and vomiting such as the Pregnancy-Unique Quantification of Emesis (PUQE) and HyperEmesis Level Prediction (HELP) tools can be used to classify the severity of NVP and HG. [Grade C] Ketonuria is not an indicator of dehydration and should not be used to assess severity. [Grade A] There are safety and efficacy data for first line antiemetics such as anti (H1) histamines, phenothiazines and doxylamine/pyridoxine (Xonvea®) and they should be prescribed initially when required for NVP and HG (Appendix III). ...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 4, 2024 Category: OBGYN Authors: Catherine Nelson-Piercy Caitlin Dean Manjeet Shehmar Roger Gadsby Margaret O'Hara Kenneth Hodson Melanie Nana Royal College of Obstetricians and Gynaecologists Source Type: research
Involvement of peripheral mast cells in a fibromyalgia model in mice
Eur J Pharmacol. 2024 Feb 2;967:176385. doi: 10.1016/j.ejphar.2024.176385. Online ahead of print.ABSTRACTFibromyalgia is a painful disorder of unknown aetiology that presents activation and recruitment of innate immune cells, including mast cells. Efforts have been made to understand its pathogenesis to manage it better. Thus, we explored the involvement of peripheral mast cells in an experimental model of fibromyalgia induced by reserpine. Reserpine (1 mg/kg) was subcutaneously (s.c.) injected once daily in the back of male Swiss mice for three consecutive days. We analysed mechanical and cold allodynia, muscle fatigue an...
Source: European Journal of Pharmacology - February 4, 2024 Category: Drugs & Pharmacology Authors: Evelyne da Silva Brum Maria Fernanda Pessano Fialho Gabriela Becker Cristina Wayne Nogueira Sara Marchesan Oliveira Source Type: research
Comparison of three different prophylactic treatments for postoperative nausea and vomiting after total joint arthroplasty under general anesthesia: a randomized clinical trial
CONCLUSION: Combined use of ondansetron, mosapride and three doses of dexamethasone can provide better antiemetic effectiveness, postoperative appetite, bowel function recovery, and pain relief than a single dose or ondansetron only.TRIAL REGISTRATION INFORMATION: The protocol was registered at the Chinese Clinical Trial Registry (ChiCTR1800015896, April 27, 2018).PMID:38291490 | PMC:PMC10826087 | DOI:10.1186/s40360-024-00735-9 (Source: BMC Pharmacology and Toxicology)
Source: BMC Pharmacology and Toxicology - January 30, 2024 Category: Drugs & Pharmacology Authors: Jinwei Xie Yingcun Cai Fuxing Pei Source Type: research
Intravenous ondansetron for the prevention of supine hypotensive syndrome during spinal anesthesia for cesarean section: a randomized controlled trial
Conclusion: Ondansetron can effectively prevent supine hypotensive syndrome, reduce the incidence of nausea, vomiting, and vasoconstrictor drug use, and improve neonatal umbilical arterial pH during spinal anesthesia for cesarean section.Clinical Trial Registration:https://www.chictr.org.cn/, identifier ChiCTR180018756. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 18, 2024 Category: Drugs & Pharmacology Source Type: research
Response to “ondansetron safety regarding prolong qtc for children with head trauma”
We read with interest the article “Ondansetron Safety Regarding Prolong QTc for Children with Head Trauma” (1). Although this article attempts to address the safety profile of ondansetron administration to children with head injury, we would like to clarify two points on statistical interpretation to provide the readers a more t horough understanding of the data. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - January 1, 2024 Category: Emergency Medicine Authors: Justin K. Rice, Kyle D. Pires, Mark K. Su Tags: Letters to the Editor Source Type: research
Alternative Causes Must Be Ruled Out Before Meningism Can Be Attributed to Acute Calcific Tendinitis of the Longus Colli Muscle
We read with interest the article by Reitz et al., who reported the case of a 51-year-old woman diagnosed with acute calcific tendinitis (ACT) of the longus colli muscle (LCM) with edema of the entire muscle and mild edema of the prevertebral and retropharyngeal space (1). She benefited from morphine, ondansetron, and acetaminophen (1). The study was impressive, but it has limitations that should be discussed. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - January 1, 2024 Category: Emergency Medicine Authors: Josef Finsterer Tags: Letter to the Editor Source Type: research
Drug-induced QT prolongation and torsade de pointes: a real-world pharmacovigilance study using the FDA Adverse Event Reporting System database
Conclusion: Our study provided a real-world overview of QT prolongation and TdP to drugs, and the presentation of the potential culprit-drug list, the proportion of reports, the detection results of ADR signals, and the distribution characteristics of ADR signals may help understand the safety profile of drugs and optimize clinical practice. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 21, 2023 Category: Drugs & Pharmacology Source Type: research
