Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment
CONCLUSIONS: Low-dose AD04 has the potential to be a safe treatment option for subjects with AUD and ALD, indicating the need for an RCT for this specific cohort. Such a trial would pave the way for the design of a precision treatment for combined AUD with ALD.PMID:38521730 | DOI:10.1016/j.ejim.2024.03.017 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - March 23, 2024 Category: Internal Medicine Authors: Giovanni Addolorato Hannu Alho Paula Bresciani M De Andrade Otto Michael Lesch Lei Liu Bankole Johnson Source Type: research
Safety and compliance of long-term low-dose ondansetron in alcohol use disorder treatment
CONCLUSIONS: Low-dose AD04 has the potential to be a safe treatment option for subjects with AUD and ALD, indicating the need for an RCT for this specific cohort. Such a trial would pave the way for the design of a precision treatment for combined AUD with ALD.PMID:38521730 | DOI:10.1016/j.ejim.2024.03.017 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - March 23, 2024 Category: Internal Medicine Authors: Giovanni Addolorato Hannu Alho Paula Bresciani M De Andrade Otto Michael Lesch Lei Liu Bankole Johnson Source Type: research
Fatal coinfection of blastocystosis and intestinal trichomoniasis in a rhesus macaque (Macaca mulatta)
AbstractA 3-year-old male rhesus macaque was presented at Referral Veterinary Polyclinic-Teaching Veterinary Clinical Complex, with a chief complaint of chronic diarrhoea and swelling of dependent body parts. The patient's history indicates that the monkey had been experiencing diarrhoea for the past month, with 2 –3 episodes of vomiting in the last 2 days. Additionally, oedema has developed within the last 2 weeks. The clinical examination findings revealed dullness and depression, the mucus membrane appeared pale, with a temperature-102.1 °F, a respiration rate-28/min, and a heart rate-92/min. The cap illary refill...
Source: Journal of Parasitic Diseases - March 19, 2024 Category: Parasitology Source Type: research
Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice
CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research
Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice
CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research
Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice
CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research
Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice
CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research
Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice
CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research
Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice
CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research
