Mild Traumatic Brain Injury-Induced Augmented Postsurgical Pain Is Driven by Central Serotonergic Pain-Facilitatory Signaling
CONCLUSIONS: Collectively, our results show that descending serotoninergic pain-facilitating signaling is responsible for nociceptive sensitization after mTBI and that central endogenous opioid tone opposes serotonin's effects. Understanding brain injury-related changes in endogenous pain modulation may lead to improved pain control for those with TBI undergoing surgery.PMID:37083595 | DOI:10.1213/ANE.0000000000006505 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 21, 2023 Category: Anesthesiology Authors: QiLiang Chen Peyman Sahbaie Karen-Amanda Irvine J David Clark Source Type: research
Mild Traumatic Brain Injury-Induced Augmented Postsurgical Pain Is Driven by Central Serotonergic Pain-Facilitatory Signaling
CONCLUSIONS: Collectively, our results show that descending serotoninergic pain-facilitating signaling is responsible for nociceptive sensitization after mTBI and that central endogenous opioid tone opposes serotonin's effects. Understanding brain injury-related changes in endogenous pain modulation may lead to improved pain control for those with TBI undergoing surgery.PMID:37083595 | DOI:10.1213/ANE.0000000000006505 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 21, 2023 Category: Anesthesiology Authors: QiLiang Chen Peyman Sahbaie Karen-Amanda Irvine J David Clark Source Type: research
Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model
Conclusion: It was also concluded that acute treatment with 1MeTIQ ameliorated STZ-induced mechanical allodynia and thermal hyperalgesia and restored brain regionally altered serotonin and dopamine concentrations which signify a potential for 1MeTIQ in the management of DPN. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research
Ondansetron Safety Regarding Prolong QTc for Children with Head Trauma
There has been recent reports of increase of QT interval following head trauma in concussed athletes and adult patients. Ondansetron, widely used in treatment of nausea and vomiting symptoms in head injuries, was issued a safety warning from the U.S. Food and Drug Administration regarding QT prolongation and the risk of fatal arrhythmias. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - March 12, 2023 Category: Emergency Medicine Authors: Remon Assaad, Rebecca E. Pratt, Brian H. Wrotniak, Haiping Qiao, Heather M. Territo Tags: Pharmacology in Emergency Medicine Source Type: research
Evaluating the effect of anti-nausea drugs in IDO enzyme gene expression and preventing postoperative vomiting and nausea in patients undergoing general anesthesia: A Meta-analysis
Cell Mol Biol (Noisy-le-grand). 2022 Sep 30;68(9):186-191. doi: 10.14715/cmb/2022.68.9.29.ABSTRACTNausea and vomiting are known as side effects after surgery. Since serotonin antagonist drugs are widely used to prevent nausea and vomiting after surgery, the present study was conducted to compare the effectiveness of this group's drugs, namely, ondansetron and palonosetron. On the other hand, recent studies have shown that the metabolites of the kynurenine pathway in the Suppression of the immune response play a role. Indoleamine 2,3 dioxygenase (IDO) is the main enzyme controlling this pathway. Therefore, the effect of the...
Source: Cellular and Molecular Biology - March 11, 2023 Category: Molecular Biology Authors: Yijian Chen Shiwen Liu Jiexian Liang Hua Zhu Source Type: research
