Unveiling the antinociceptive mechanisms of Methyl-2-(4-chloro-phenyl)-5-benzoxazoleacetate: insights from nociceptive assays in mice

CONCLUSIONS: MCBA-induced antinociception involves modulation of glutamatergic-, TRVP1 receptors- and PKC-signaling pathways. It impacts adenosinergic, alpha-2 adrenergic, and cholinergic receptors and opens ATP-sensitive potassium channels.PMID:38497888 | DOI:10.26355/eurrev_202403_35620

Source: Pharmacological Reviews - March 18, 2024 Category: Drugs & Pharmacology Authors: Q Jarrar R Ayoub Y Jarrar H Jaffal K W Goh L C Ming S Moshawih A Sirhan Source Type: research