Egg allergy and yellow fever vaccination
CONCLUSION: There is a relationship between the positivity of the egg's components and the severity of the clinical reaction. Furthermore, the relationship between the positivity of the tests with the YFV and egg's components may show a tendency to look at ovomucoid and conalbumin, but it is not a certainty. Therefore, further studies are needed to confirm these associations, and for now, the authors still recommend using the vaccine for testing when necessary.PMID:37597532 | DOI:10.1016/j.jped.2023.07.004 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 19, 2023 Category: Pediatrics Authors: B árbara L B Cançado Carolina S Aranda Marcia C Mallozi Lily Y Weckx Dirceu Sol é Source Type: research
Egg allergy and yellow fever vaccination
CONCLUSION: There is a relationship between the positivity of the egg's components and the severity of the clinical reaction. Furthermore, the relationship between the positivity of the tests with the YFV and egg's components may show a tendency to look at ovomucoid and conalbumin, but it is not a certainty. Therefore, further studies are needed to confirm these associations, and for now, the authors still recommend using the vaccine for testing when necessary.PMID:37597532 | DOI:10.1016/j.jped.2023.07.004 (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 19, 2023 Category: Pediatrics Authors: B árbara L B Cançado Carolina S Aranda Marcia C Mallozi Lily Y Weckx Dirceu Sol é Source Type: research
Molecular surveillance of arboviruses in Nigeria
Arboviral infections are fast becoming a global public health concern as a result of its high fatality rate and sporadic spread. From the outbreak of Zika virus in the Americas, the endemicity of Yellow fever ... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - August 18, 2023 Category: Infectious Diseases Authors: Joseph Ojonugwa Shaibu, Kabiru Olusegun Akinyemi, Oshilonyah Henry Uzor, Rosemary Ajuma Audu and Akeeb Bola Oriowo Oyefolu Tags: Research Source Type: research
Genes, Vol. 14, Pages 1626: Comparative Transcriptomic Analysis of Insecticide-Resistant Aedes aegypti from Puerto Rico Reveals Insecticide-Specific Patterns of Gene Expression
Audrey Lenhart
Aedes aegypti transmits major arboviruses of public health importance, including dengue, chikungunya, Zika, and yellow fever. The use of insecticides represents the cornerstone of vector control; however, insecticide resistance in Ae. aegypti has become widespread. Understanding the molecular basis of insecticide resistance in this species is crucial to design effective resistance management strategies. Here, we applied Illumina RNA-Seq to study the gene expression patterns associated with resistance to three widely used insecticides (malathion, alphacypermethrin, and lambda-cyhalothrin) in Ae. aegypt...
Source: Genes - August 15, 2023 Category: Genetics & Stem Cells Authors: Dieunel Derilus Lucy Mackenzie Impoinvil Ephantus J. Muturi Janet McAllister Joan Kenney Steven E. Massey Ryan Hemme Linda Kothera Audrey Lenhart Tags: Article Source Type: research
Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021 –2022
J. Bonney et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - August 9, 2023 Category: Infectious Diseases Source Type: research
Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic
Biomed Pharmacother. 2023 Aug 3;165:115254. doi: 10.1016/j.biopha.2023.115254. Online ahead of print.ABSTRACTDespite the development of new biological and synthetic targeted therapies, methotrexate remains one of the most commonly used immunomodulatory drugs in rheumatology. However, its effect on the immunogenicity of vaccines has been studied only to a limited extent until recently, resulting in the lack of clear guidelines on the use of methotrexate during vaccination. Significant progress was made during the COVID-19 pandemic due to the dynamic development of research on vaccines, including patients with autoimmune inf...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 5, 2023 Category: Drugs & Pharmacology Authors: Jakub Wro ński Marzena Ciechomska Ewa Kuca-Warnawin Source Type: research
Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic
Biomed Pharmacother. 2023 Aug 3;165:115254. doi: 10.1016/j.biopha.2023.115254. Online ahead of print.ABSTRACTDespite the development of new biological and synthetic targeted therapies, methotrexate remains one of the most commonly used immunomodulatory drugs in rheumatology. However, its effect on the immunogenicity of vaccines has been studied only to a limited extent until recently, resulting in the lack of clear guidelines on the use of methotrexate during vaccination. Significant progress was made during the COVID-19 pandemic due to the dynamic development of research on vaccines, including patients with autoimmune inf...
Source: Herpes - August 5, 2023 Category: Infectious Diseases Authors: Jakub Wro ński Marzena Ciechomska Ewa Kuca-Warnawin Source Type: research
Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic
Biomed Pharmacother. 2023 Aug 3;165:115254. doi: 10.1016/j.biopha.2023.115254. Online ahead of print.ABSTRACTDespite the development of new biological and synthetic targeted therapies, methotrexate remains one of the most commonly used immunomodulatory drugs in rheumatology. However, its effect on the immunogenicity of vaccines has been studied only to a limited extent until recently, resulting in the lack of clear guidelines on the use of methotrexate during vaccination. Significant progress was made during the COVID-19 pandemic due to the dynamic development of research on vaccines, including patients with autoimmune inf...
Source: Herpes - August 5, 2023 Category: Infectious Diseases Authors: Jakub Wro ński Marzena Ciechomska Ewa Kuca-Warnawin Source Type: research
Large-scale reference-free analysis of flavivirus sequences in Aedes aegypti whole genome DNA sequencing data
Flaviviruses are a diverse group of RNA viruses, which include the etiological agents of Zika, dengue and yellow fever that are transmitted by mosquitoes. Flaviviruses do not encode reverse transcriptase and c... (Source: Parasites and Vectors)
Source: Parasites and Vectors - August 5, 2023 Category: Microbiology Authors: Anton Spadar, Jody E. Phelan, Taane G. Clark and Susana Campino Tags: Brief Report Source Type: research
Modeling the impact of vaccination for the immunization Agenda 2030: Deaths averted due to vaccination against 14 pathogens in 194 countries from 2021 to 2030
Vaccine. 2023 Aug 1:S0264-410X(23)00854-X. doi: 10.1016/j.vaccine.2023.07.033. Online ahead of print.ABSTRACTBACKGROUND: The Immunization Agenda 2030 (IA2030) Impact Goal 1.1. aims to reduce the number of future deaths averted through immunization in the next decade. To estimate the potential impact of the aspirational coverage targets for IA2030, we developed an analytical framework and estimated the number of deaths averted due to an ambitious vaccination coverage scenario from 2021 to 2030 in 194 countries.METHOD: A demographic model was used to determine annual age-specific mortality estimates associated with vaccine c...
Source: Vaccine - August 3, 2023 Category: Allergy & Immunology Authors: Austin Carter William Msemburi So Yoon Sim Katy A M Gaythorpe Philipp Lambach Ann Lindstrand Raymond Hutubessy Source Type: research
Modeling the impact of vaccination for the immunization Agenda 2030: Deaths averted due to vaccination against 14 pathogens in 194 countries from 2021 to 2030
Vaccine. 2023 Aug 1:S0264-410X(23)00854-X. doi: 10.1016/j.vaccine.2023.07.033. Online ahead of print.ABSTRACTBACKGROUND: The Immunization Agenda 2030 (IA2030) Impact Goal 1.1. aims to reduce the number of future deaths averted through immunization in the next decade. To estimate the potential impact of the aspirational coverage targets for IA2030, we developed an analytical framework and estimated the number of deaths averted due to an ambitious vaccination coverage scenario from 2021 to 2030 in 194 countries.METHOD: A demographic model was used to determine annual age-specific mortality estimates associated with vaccine c...
Source: Vaccine - August 3, 2023 Category: Allergy & Immunology Authors: Austin Carter William Msemburi So Yoon Sim Katy A M Gaythorpe Philipp Lambach Ann Lindstrand Raymond Hutubessy Source Type: research
Acetylation of the NS3 helicase by KAT5 γ is essential for flavivirus replication
Cell Host Microbe. 2023 Jul 14:S1931-3128(23)00264-0. doi: 10.1016/j.chom.2023.06.013. Online ahead of print.ABSTRACTDirect targeting of essential viral enzymes such as proteases, polymerases, and helicases has long been the major focus of antiviral drug design. Although successful for some viral enzymes, targeting viral helicases is notoriously difficult to achieve, demanding alternative strategies. Here, we show that the NS3 helicase of Zika virus (ZIKV) undergoes acetylation in its RNA-binding tunnel. Regulation of the acetylated state of K389 in ZIKV NS3 modulates RNA binding and unwinding and is required for efficient...
Source: Cell Host and Microbe - July 21, 2023 Category: Microbiology Authors: Taryn Serman Cindy Chiang GuanQun Liu Zuberwasim Sayyad Shanti Pandey Meta Volcic Haejeong Lee Santoshi Muppala Dhiraj Acharya Christopher Goins Shaun R Stauffer Konstantin M J Sparrer Michaela U Gack Source Type: research
Yellow Fever Reemergence Risk in the Guiana Shield: a Comprehensive Review of Cases Between 1990 and 2022
In conclusion, the sylvatic cyc le of the YF virus is likely to persist in this region. Absence of vaccination or unknown immunization status was documented in most patients (78%). The mortality rate of this case series was high thus highlighting the need to strengthen vaccination coverage for the population and travelers to the G S. (Source: Current Tropical Medicine Reports)
Source: Current Tropical Medicine Reports - July 18, 2023 Category: Tropical Medicine Source Type: research
Phospholipid binding of the dengue virus envelope E protein segment containing the conserved His residue
Biochim Biophys Acta Biomembr. 2023 Jul 10:184198. doi: 10.1016/j.bbamem.2023.184198. Online ahead of print.ABSTRACTFlaviviruses encompass many important human pathogens, including Dengue, Zika, West Nile, Yellow fever, Japanese encephalitis, and Tick-borne encephalitis viruses as well as several emerging viruses that affect millions of people worldwide. They enter cells by endocytosis, fusing their membrane with the late endosomal one in a pH-dependent manner, so membrane fusion is one of the main targets for obtaining new antiviral inhibitors. The envelope E protein, a class II membrane fusion protein, is responsible for...
Source: Biochimica et Biophysica Acta - July 12, 2023 Category: Biochemistry Authors: Jos é Villalaín Source Type: research
Phospholipid binding of the dengue virus envelope E protein segment containing the conserved His residue
Biochim Biophys Acta Biomembr. 2023 Jul 10:184198. doi: 10.1016/j.bbamem.2023.184198. Online ahead of print.ABSTRACTFlaviviruses encompass many important human pathogens, including Dengue, Zika, West Nile, Yellow fever, Japanese encephalitis, and Tick-borne encephalitis viruses as well as several emerging viruses that affect millions of people worldwide. They enter cells by endocytosis, fusing their membrane with the late endosomal one in a pH-dependent manner, so membrane fusion is one of the main targets for obtaining new antiviral inhibitors. The envelope E protein, a class II membrane fusion protein, is responsible for...
Source: Biochimica et Biophysica Acta - July 12, 2023 Category: Biochemistry Authors: Jos é Villalaín Source Type: research
