Supreme glutathione-dependent ketosteroid isomerase in the yellow-fever transmitting mosquito Aedes aegypti
Biochem Biophys Res Commun. 2024 Apr 7;711:149914. doi: 10.1016/j.bbrc.2024.149914. Online ahead of print.ABSTRACTThe steroid hormone ecdysone is essential for the reproduction and survival of insects. The hormone is synthesized from dietary sterols such as cholesterol, yielding ecdysone in a series of consecutive enzymatic reactions. In the insect orders Lepidoptera and Diptera a glutathione transferase called Noppera-bo (Nobo) plays an essential, but biochemically uncharacterized, role in ecdysteroid biosynthesis. The Nobo enzyme is consequently a possible target in harmful dipterans, such as disease-carrying mosquitoes....
Source: Biochemical and Biophysical Research communications - April 12, 2024 Category: Biochemistry Authors: Katar ína Šťastná Yaman Musdal Aram Ismail Kana Ebihara Ryusuke Niwa Bengt Mannervik Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
Circulation of yellow fever virus in Benin city, Edo state Nigeria
Biologicals. 2024 Apr 8;86:101765. doi: 10.1016/j.biologicals.2024.101765. Online ahead of print.ABSTRACTYellow fever (YF) is one of the most acute viral hemorrhagic diseases of the 18th and 19th centuries, which continues to cause severe morbidity and mortality in Africa. After 21 years of no reported cases of yellow fever in Nigeria, till 2017 where a case was confirmed in Kwara State, also in November 2018,WHO was informed of a cluster of suspected yellow fever cases and deaths in Edo state, Nigeria. The study was among all age group attending health centres in Benin City, Edo state. A total of 280 blood samples were co...
Source: Biologicals : Journal of the International Association of Biological Standardization - April 9, 2024 Category: Biotechnology Authors: Joy Zitgwai Saidu Nosakhare Odeh Eghafona Source Type: research
YF17D-based vaccines - standing on the shoulders of a giant
Eur J Immunol. 2024 Apr 3:e2250133. doi: 10.1002/eji.202250133. Online ahead of print.ABSTRACTLive-attenuated yellow fever vaccine (YF17D) was developed in the 1930s as the first ever empirically derived human vaccine. Ninety years later, it is still a benchmark for vaccines made today. YF17D triggers a particularly broad and polyfunctional response engaging multiple arms of innate, humoral and cellular immunity. This unique immunogenicity translates into an extraordinary vaccine efficacy and outstanding longevity of protection, possibly by single-dose immunization. More recently, progress in molecular virology and synthet...
Source: European Journal of Immunology - April 4, 2024 Category: Allergy & Immunology Authors: Lorena Sanchez-Felipe Yeranddy A Alpizar Ji Ma Lotte Coelmont Kai Dallmeier Source Type: research
Biased virus transmission following sequential coinfection of < i > Aedes aegypti < /i > with dengue and Zika viruses
Conclusions/significanceOur findings suggest that, in contrast to simultaneous arbovirus coinfection in mosquitoes that can promote the transmission and co-circulation of these viruses, sequential coinfection appears to have limited influence on arbovirus transmission dynamics. However, it is important to note that more experimental investigations are needed to refine and expand upon this conclusion. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 1, 2024 Category: Tropical Medicine Authors: Jiameng Peng Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Anti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA
CONCLUSION: This finding suggests that in cases where individuals receiving HPV vaccination experience psychiatric or neurological symptoms, it should be considered to diagnose anti-NMDA receptor encephalitis, given the exclusion of other possible complications.PMID:38549528 | DOI:10.2174/0109298673264615231124072130 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Hsiuying Wang Source Type: research
Transgenic line for characterizing GABA-receptor expression to study the neural basis of olfaction in the yellow-fever mosquito
The mosquito Aedes aegypti is an important vector of diseases including dengue, Zika, chikungunya, and yellow fever. Olfaction is a critical modality for mosquitoes enabling them to locate hosts, sources of nectar, and sites for oviposition. GABA is an essential neurotransmitter in olfactory processing in the insect brain, including the primary olfactory center, the antennal lobe. Previous work with Ae. aegypti has suggested that antennal lobe inhibition via GABA may be involved in the processing of odors. However, little is known about GABA receptor expression in the mosquito brain, or how they may be involved in odor att...
Source: Frontiers in Physiology - March 28, 2024 Category: Physiology Source Type: research
