Viruses, Vol. 16, Pages 31: YELLOW ALERT: Persistent Yellow Fever Virus Circulation among Non-Human Primates in Urban Areas of Minas Gerais State, Brazil (2021 & ndash;2023)
This study aimed to investigate whether YFV circulation persisted in NHP after the human outbreak had subsided. To this end, NHP carcass samples collected in Minas Gerais from 2021 to 2023 were screened for YFV. RNA was extracted from tissue fragments and used in RT-qPCR targeting the YFV 5’UTR. Liver and lung samples from 166 animals were tested, and the detection of the β-actin mRNA was used to ensure adequacy of RNA isolation. YFV RNA was detected in the liver of 18 NHP carcasses collected mainly from urban areas in 2021 and 2022. YFV positive NHP were mostly represented by Callithrix, from 5 ...
Source: Viruses - December 23, 2023 Category: Virology Authors: Gabriela F. Garcia-Oliveira Anna Catarina Dias Soares Guimar ães Gabriel Dias Moreira Thais Alkifeles Costa Matheus Soares Arruda Érica Munhoz de Mello Marlise Costa Silva Munique Guimar ães de Almeida Kathryn A. Hanley Nikos Vasilakis Bet ânia Paiva Tags: Communication Source Type: research
Viruses, Vol. 16, Pages 23: A Multiplex Nanopore Sequencing Approach for the Detection of Multiple Arboviral Species
In this study, we integrated nanopore sequencing and the advantages of reverse transcription polymerase chain reaction (RT-PCR) to develop a multiplex RT-PCR protocol for the detection of Chikungunya virus (CHIKV) and several orthoflaviviruses (such as dengue (Orthoflavivirus dengue), Zika (Orthoflavivirus zikaense), yellow fever (Orthoflavivirus flavi), and West Nile (Orthoflavivirus nilense) viruses) in a single reaction, which provides data for sequence-based differentiation of arbovirus lineages. (Source: Viruses)
Source: Viruses - December 22, 2023 Category: Virology Authors: Joilson Xavier Vagner Fonseca Talita Adelino Felipe C. M. Iani Glauco C. Pereira Myrian M. Duarte Mauricio Lima Emerson Castro Carla Oliveira Hegger Fritsch Natalia Guimar ães Ludmila O. Lamounier Fernanda Khouri Barreto Camilo M. M. Braga de Oliveira Cr Tags: Brief Report Source Type: research
Elongation of N < sup > 6 < /sup > -benzyladenosine scaffold via Pd-catalyzed C-C bond formation leads to derivatives with antiflaviviral activity
Bioorg Med Chem. 2023 Dec 10;98:117552. doi: 10.1016/j.bmc.2023.117552. Online ahead of print.ABSTRACTDecoration of nucleoside analogues with lipophilic groups often leads to compounds with improved antiviral activity. For example, N6-benzyladenosine derivatives containing elongated lipophilic substituents in the benzyl core efficiently inhibit reproduction of tick-borne encephalitis virus (TBEV), while N6-benzyladenosine itself potently inhibits reproduction of human enterovirus A71 (EV-A71). We have extended a series of N6-benzyladenosine analogues using effective synthetic methods of CC bond formation based on Pd-cataly...
Source: Bioorganic and Medicinal Chemistry - December 21, 2023 Category: Chemistry Authors: Anastasia A Zenchenko Mikhail S Drenichev Evgeny V Khvatov Victoria I Uvarova Alexander S Goryashchenko Vasilisa S Frolenko Evgenia V Karpova Liubov I Kozlovskaya Dmitry I Osolodkin Aydar A Ishmukhametov Sergey N Mikhailov Vladimir E Oslovsky Source Type: research
Elongation of N < sup > 6 < /sup > -benzyladenosine scaffold via Pd-catalyzed C-C bond formation leads to derivatives with antiflaviviral activity
Bioorg Med Chem. 2023 Dec 10;98:117552. doi: 10.1016/j.bmc.2023.117552. Online ahead of print.ABSTRACTDecoration of nucleoside analogues with lipophilic groups often leads to compounds with improved antiviral activity. For example, N6-benzyladenosine derivatives containing elongated lipophilic substituents in the benzyl core efficiently inhibit reproduction of tick-borne encephalitis virus (TBEV), while N6-benzyladenosine itself potently inhibits reproduction of human enterovirus A71 (EV-A71). We have extended a series of N6-benzyladenosine analogues using effective synthetic methods of CC bond formation based on Pd-cataly...
Source: Bioorganic and Medicinal Chemistry - December 21, 2023 Category: Chemistry Authors: Anastasia A Zenchenko Mikhail S Drenichev Evgeny V Khvatov Victoria I Uvarova Alexander S Goryashchenko Vasilisa S Frolenko Evgenia V Karpova Liubov I Kozlovskaya Dmitry I Osolodkin Aydar A Ishmukhametov Sergey N Mikhailov Vladimir E Oslovsky Source Type: research
Aedes albopictus distribution in Ibagu é, Colombia: Potential risk of arboviral outbreaks
CONCLUSIONS: Aedes albopictus is distributed throughout all the communes of Ibague. Its dispersion has probably been favored by this region’s environmental and social conditions. We recommend annual monitoring of these vectors populations and molecular characterization of the found arboviruses. Ascertaining this mosquito’s distribution throughout the city will enable focusing entomological control strategies and preventing future arbovirus outbreaks.PMID:38109139 | DOI:10.7705/biomedica.7010 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - December 18, 2023 Category: International Medicine & Public Health Authors: Cristian Camilo Canizales Julio Cesar Carranza Gustavo Adolfo Vallejo Daniel Alfonso Urrea Source Type: research
