Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 23:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells andin animal models.Anin vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a dose-de...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 23:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells andin animal models.Anin vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a dose-de...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 23:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells andin animal models.Anin vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a dose-de...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 23:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells andin animal models.Anin vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a dose-de...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 24;219:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells and in animal models.An in vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a d...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 24;219:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells and in animal models.An in vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a d...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 24;219:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells and in animal models.An in vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a d...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research
Fatal acute undifferentiated febrile illness among clinically suspected leptospirosis cases in Colombia, 2016 –2019
Conclusions/SignificanceThis study underscores the importance of early and accurate recognition of leptospirosis to prevent mortalities. Moreover, it draws attention to the existence of other febrile syndromes in Colombia, including rickettsiosis and brucellosis, that currently lack sufficient human surveillance and regular reporting. Expanding laboratory surveillance to include viruses such as Hantavirus, Mayaro virus, Oropouche virus, and West Nile virus is crucial. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - October 16, 2023 Category: Tropical Medicine Authors: Eliana L. Parra Barrera Source Type: research
Syphilis, < em > blanchiment < /em > and French colonial medicine in sub-Saharan Africa during the interwar period
This article demonstrates the contradictory nature of the colonial medicine approach to this disease during the interwar years. The negative impact of syphilis on population growth in Africa made it a major threat to the colonial project, and France put significant, costly investment into tackling the disease, focusing its efforts on maternal and child health. However, a closer look at syphilis control in sub-Saharan Africa reveals that the disease was also minimised as a public health issue, under-resourced and downplayed by colonial doctors and administrators. This neglect was embodied in the invention of a new colonial ...
Source: Medical History - October 13, 2023 Category: History of Medicine Authors: Guillaume Linte Source Type: research
Syphilis, < em > blanchiment < /em > and French colonial medicine in sub-Saharan Africa during the interwar period
This article demonstrates the contradictory nature of the colonial medicine approach to this disease during the interwar years. The negative impact of syphilis on population growth in Africa made it a major threat to the colonial project, and France put significant, costly investment into tackling the disease, focusing its efforts on maternal and child health. However, a closer look at syphilis control in sub-Saharan Africa reveals that the disease was also minimised as a public health issue, under-resourced and downplayed by colonial doctors and administrators. This neglect was embodied in the invention of a new colonial ...
Source: Medical History - October 13, 2023 Category: History of Medicine Authors: Guillaume Linte Source Type: research
An 11-point time course midgut transcriptome across 72 h after bloodfeeding provides detailed temporal resolution of transcript expression in the arbovirus vector, Aedes aegypti [RESOURCES]
This study provides a powerful resource for the analysis of genomic features that coordinate the rapid and complex transcriptional program induced by mosquito bloodfeeding. (Source: Genome Research)
Source: Genome Research - October 13, 2023 Category: Genetics & Stem Cells Authors: Tsujimoto, H., Adelman, Z. N. Tags: RESOURCES Source Type: research
Aedes aegypti abundance in urban neighborhoods of Maricopa County, Arizona, is linked to increasing socioeconomic status and tree cover
Understanding coupled human-environment factors which promote Aedes aegypti abundance is critical to preventing the spread of Zika, chikungunya, yellow fever and dengue viruses. High temperatures and aridity theo... (Source: Parasites and Vectors)
Source: Parasites and Vectors - October 8, 2023 Category: Microbiology Authors: Jenna E. Coalson, Danielle M. Richard, Mary H. Hayden, John Townsend, Dan Damian, Kirk Smith, Andrew Monaghan and Kacey C. Ernst Tags: Research Source Type: research
An 11-point time course midgut transcriptome across 72 h after bloodfeeding provides detailed temporal resolution of transcript expression in the arbovirus vector, Aedes aegypti [RESOURCES]
This study provides a powerful resource for the analysis of genomic features that coordinate the rapid and complex transcriptional program induced by mosquito bloodfeeding. (Source: Genome Research)
Source: Genome Research - October 6, 2023 Category: Genetics & Stem Cells Authors: Tsujimoto, H., Adelman, Z. N. Tags: RESOURCES Source Type: research
HSPA13 modulates type I interferon antiviral pathway and NLRP3 inflammasome to restrict dengue virus infection in macrophages
Int Immunopharmacol. 2023 Sep 28;124(Pt B):110988. doi: 10.1016/j.intimp.2023.110988. Online ahead of print.ABSTRACTDengue virus (DENV) is a type of arthropod-borne Flavivirus, which leads to a series of serious diseases like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). DENV has a devastating health and economic impact worldwide. However, there are no suitable drugs to combat the virus. Here we reported that HSPA13, also known as stress chaperone (STCH), is a member of the HSP70 family and is a key regulator of type I interferon (IFN-I) and pro-inflammatory responses during DENV infection. HSPA13 express...
Source: International Immunopharmacology - September 30, 2023 Category: Allergy & Immunology Authors: Qiaohua Wang Jingwen Yang Xingyu Li Wei Wang Yongjian Wu Zhijian Li Xi Huang Source Type: research
HSPA13 modulates type I interferon antiviral pathway and NLRP3 inflammasome to restrict dengue virus infection in macrophages
Int Immunopharmacol. 2023 Sep 28;124(Pt B):110988. doi: 10.1016/j.intimp.2023.110988. Online ahead of print.ABSTRACTDengue virus (DENV) is a type of arthropod-borne Flavivirus, which leads to a series of serious diseases like dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). DENV has a devastating health and economic impact worldwide. However, there are no suitable drugs to combat the virus. Here we reported that HSPA13, also known as stress chaperone (STCH), is a member of the HSP70 family and is a key regulator of type I interferon (IFN-I) and pro-inflammatory responses during DENV infection. HSPA13 express...
Source: International Immunopharmacology - September 30, 2023 Category: Allergy & Immunology Authors: Qiaohua Wang Jingwen Yang Xingyu Li Wei Wang Yongjian Wu Zhijian Li Xi Huang Source Type: research
