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Native fungi from Amazon with potential for control of Aedes aegypti L. (Diptera: Culicidae)
Braz J Biol. 2023 Oct 27;83:e274954. doi: 10.1590/1519-6984.274954. eCollection 2023.ABSTRACTAedes aegypti L. (Diptera: Culicidae) is the main transmitter of pathogens that cause human diseases, including dengue, chikungunya, zika and yellow fever. Faced with this problem, this study aims to select fungi with entomopathogenic potential against Ae. aegypti and develop formulations that optimize the control action of entomopathogenic fungi in the semi-field condition. 23 fungal strains native from Amazon were inoculated in Potato-Dextrose-Agar (PDA) culture medium for 14 days and then transferred by scraping to tubes contain...
Source: Braz J Biol - November 1, 2023 Category: Biology Authors: G R Q Mendon ça L P Peters L M Lopes A H Sousa C M Carvalho Source Type: research

Fitness costs in the presence and absence of insecticide use explains abundance of two common < i > Aedes aegypti kdr < /i > resistance alleles found in the Americas
In this study, we conducted a population cage experiment to evaluate changes in the allele and genotype frequencies of the410L+1016I+1534C allele by crossing two congenic strains; one carrying the410L+1016I+1534C and another with the 1534C allele. Changes in allele frequencies were measured over 10 generations in the absence of insecticide exposure. We also applied one cycle of selection with deltamethrin at F9 to evaluate the changes in allele and genotype frequencies. Our findings indicate that fitness costs were higher with the410L+1016I+1534C allele, relative to the1534C allele, in the absence of deltamethrin exposure,...
Source: PLoS Neglected Tropical Diseases - November 1, 2023 Category: Tropical Medicine Authors: Juan J. Silva Source Type: research

Increased blood meal size and feeding frequency compromise < i > Aedes aegypti < /i > midgut integrity and enhance dengue virus dissemination
by Rebecca M. Johnson, Duncan W. Cozens, Zannatul Ferdous, Philip M. Armstrong, Doug E. BrackneyAedes aegypti is a highly efficient vector for numerous pathogenic arboviruses including dengue virus (DENV), Zika virus, and yellow fever virus. This efficiency can in part be attributed to their frequent feeding behavior. We previously found that acquisition of a second, full, non-infectious blood meal could accelerate virus dissemination within the mosquito by temporarily compromising midgut basal lamina integrity; however, in the wild, mosquitoes are often interrupted during feeding and only acquire partial or minimal blood ...
Source: PLoS Neglected Tropical Diseases - November 1, 2023 Category: Tropical Medicine Authors: Rebecca M. Johnson Source Type: research

Mosquito-borne flaviviruses and type I interferon: catch me if you can!
Mosquito-borne flaviviruses include many viruses that are important human pathogens, including Yellow fever virus, Dengue virus, Zika virus and West Nile virus. While these viruses have long been confined to tropical regions, they now pose a global public health concern, as the geographical distribution of their mosquito vectors has dramatically expanded. The constant threat of flavivirus emergence and re-emergence underlines the need for a better understanding of the relationships between these viruses and their hosts. In particular, unraveling how these viruses manage to bypass antiviral immune mechanisms could enable th...
Source: Frontiers in Microbiology - October 30, 2023 Category: Microbiology Source Type: research

Trends in emerging vector-borne viral infections and their outcome in children over two decades
Pediatr Res. 2023 Oct 25. doi: 10.1038/s41390-023-02866-x. Online ahead of print.ABSTRACTThis review utilizes quatitative methods and bibliometric data to analyse the trends of emerging and re-emerging vector-borne diseases, with a focus on their impact on pediatric population. To conduct this analysis, a systematic search of PubMed articles from the past two decades was performed, specifically looking at 26 different vector-borne viruses listed in WHO and CDC list of vector-borne viruses. The review found that diseases like Dengue, Zika, West Nile, and Chikungunya were frequently discussed in the literature. On the other ...
Source: Pediatric Research - October 25, 2023 Category: Pediatrics Authors: Kaushik Mukhopadhyay Mallika Sengupta Saheli Chatterjee Misra Kiranmay Majee Source Type: research

Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 23:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells andin animal models.Anin vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a dose-de...
Source: Antiviral Research - October 25, 2023 Category: Virology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research

Tiratricol inhibits yellow fever virus replication through targeting viral RNA-dependent RNA polymerase of NS5
Antiviral Res. 2023 Oct 23:105737. doi: 10.1016/j.antiviral.2023.105737. Online ahead of print.ABSTRACTYellow fever virus (YFV) infection is a major public concern that threatens a large population in South America and Africa. No specific antiviral drugs are available for treating yellow fever. Here, we report that tiratricol (triiodothyroacetic acid, TRIAC), a clinically approved drug used to treat thyroid hormone resistance syndrome (THRS), is a potent YFV inhibitor both in host cells andin animal models.Anin vitro study demonstrates that TRIAC remarkably suppresses viral RNA synthesis and protein expression in a dose-de...
Source: Cell Research - October 25, 2023 Category: Cytology Authors: Hao Ren Jiaqi Wang Hailin Tang Xijing Qian Binghui Xia Zhenghan Luo Zhenghao Xu Zhongtian Qi Ping Zhao Source Type: research