A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
The synergy of AI and human intelligence in transforming health care
The health care industry is witnessing a transformative phase with the integration of artificial intelligence (AI). AI’s ability to process vast amounts of data and provide predictive insights is revolutionizing medical diagnostics and patient care. AI’s precision is invaluable in diagnosing and managing kidney disease, offering both speed and accuracy in analyzing patient data. Unleashing
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The synergy of AI and human intelligence in transforming health care originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 4, 2023 Category: General Medicine Authors: Harvey Castro, MD, MBA Tags: Tech Health IT Source Type: blogs
Can you try these two questions on Amyloid ?
Is it a physiological molecule ?
1.Yes, It is a physiological molecule.
2.No, Amyloid is always pathological.
Where does it gets deposited ?
A .Extracellular*
B. Intracellular
C. Both
Answer : Q 1: A / Q 2: C. It is indeed a physiological molecule in small amounts that help carry hormones across the blood. In pathology, it accumulates in huge amounts. It is a disorder of protein folding, making them thick, stiff , sheets of peptide, hence mis-behaving with adjacent cells, injuring them in the process. This is responsible for the systemic nature of disorder right from the brain to peripheral nerves, H...
Source: Dr.S.Venkatesan MD - December 1, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Alzheimer disease amyloidosis ttr amyloid what is amyloid Source Type: blogs
How Patient Activation Made It Possible to Thrive with Kidney Disease
By DAVE WHITE
It had been 10 years since I’d seen a doctor when I arrived at the Emergency Room at George Washington University Hospital in October 2009. I was able to climb the first flight of stairs, but after I froze on the second, they brought me in on a wheelchair.
That was the first time I heard the dreaded words, “Your kidneys aren’t working.” I was put on dialysis immediately, and my life transformed into a series of tests and procedures. But even after three weeks at the hospital, it didn’t sink in that there was no cure.
I checked most risk factors for kidney disease: I ate the wrong foods, smo...
Source: The Health Care Blog - November 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy chronic kidney disease Dave White Patient Activation Measure Patient Activism patient advocacy Source Type: blogs
A Novel Mitophagy Inducing Compound
A sizable fraction of research aimed at treating aging involves screening natural compounds in search of those that can modestly slow aging in short-lived animal models. This is because the economics of developing such a compound into a drug or supplement are well understood by investors, and because it dovetails well with the scientific goal of increased understanding of how aging progresses at the level of cellular biochemistry, rather than because it is going to make a big difference for patients. If sizable gains in healthy life span were the driving incentive, the field would look very different, and the emphasis woul...
Source: Fight Aging! - November 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Assessing Pentadecanoic Acid In Vitro
The work on pentadecanoic acid noted here is interesting, but should be taken with a grain of salt given that it is performed in vitro. In general, one should expect any given set of mechanisms in the cell to be associated with many different means of manipulation. It is interesting to see a fatty acid capable of touching on the same mechanisms as rapamycin, but remember that the ability to influence the same mechanistic targets does not necessarily translate to the same ability to produce a modest slowing of aging in animal studies. So the usual advice stands here, to wait for the animal studies before getting too excited...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Therapy to Reduce Lipoprotein(a) Levels
The research and development community is ever in search of the next statin drug, and a way to reduce lipoprotein(a) levels looks very much like an alternative statin. Statins reduce the amount of cholesterol carried by LDL particles in the bloodstream. Lipoprotein(a) is a carrier of cholesterol, like LDL, and research has shown that high levels correlate with the development of atherosclerotic lesions, as is the case for LDL-cholesterol. That being so, one can't be all that optimistic that a treatment to reduce lipoprotein(a) will actually do much for disease risk. Statins reduce risk of stroke and heart attack resulting ...
Source: Fight Aging! - November 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Patient Engagement through Communication Platforms
With the increase in digital health, remote care, and patient access, the need for a reliable platform to conduct everything has also increased. But while we all need reliable communication platforms, properly utilizing them is an entirely different story. There is already so much to consider in terms of what works best for your organization, but then you need to rethink everything in terms of what is best for the patient. You might be reassured that it is safe and easy to use on the administrator end, but is it that way on the user end for the patients?
For some insights on patient engagement in communication platforms we...
Source: EMR and HIPAA - November 17, 2023 Category: Information Technology Authors: Grayson Miller Tags: Ambulatory C-Suite Leadership Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System LTPAC Cassie Choi Communication Platform David Wright hc1 Insights HSBlox John Moyer Kathy Ford Kel Pul Source Type: blogs
Case of the Week 731
The following objects were seen in fluid aspirated from a cyst in the liver. Identification?Some were still moving! (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - November 16, 2023 Category: Parasitology Source Type: blogs
Answer to Case 731
Answer to theParasite Case of the Week 731:Echinococcussp. protoscolex. Hopefully you all got to look at it moving! Given that this is a single liver cyst, it would fit withE. granulosus. Correlation with radiologic and epidemiologic features would be helpful for confirmation.Here are some of the key diagnostic features: (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - November 14, 2023 Category: Parasitology Source Type: blogs
SCAN Group Makes Strategic Investment in Dina
SCAN Group, a mission-driven organization whose holdings include SCAN Health Plan, one of the nation’s largest not-for-profit Medicare Advantage plans, has made its latest strategic investment in Dina. Dina provides digital care-at-home network management and coordination solutions to help health plans and providers improve access to a variety of in-home care services.
“We are excited to support Dina and the work they are doing to innovate and deliver rapid, efficient solutions that provide access to home and community-based services,” said Deepa Sheth, Chief Corporate Development Officer at SCAN Group. “It is pa...
Source: EMR and HIPAA - November 14, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Arine Ashish V. Shah Deepa Sheth dina Guaranteed Health IT Funding Health IT Fundings Health IT Investment MedArrive Monogram Health SafelyYou SafeRide Health SCAN Group SCAN Health Plan Source Type: blogs
Lifestyle Choices Do Slow Aging, Just Not as Much as We'd Like
In recent years, a number of epidemiological studies have demonstrated that people with healthier lifestyles tend to live longer, at least within the bounds of later life from 60 to 100. That in turn is reflected by a lesser burden of various forms of cell and tissue damage, such as the accumulation of senescent cells. This isn't a controversial statement, though there is room enough to argue for an eternity over just how large the effect of any specific choice might be, how that effect size varies between populations, how different choices combine, and so forth. Then on top of all of this, the question of what happens and...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Medical ethics dilemma: a hemodialysis decision
An excerpt from The Committee Will Kill You Now. “You couldn’t get her niece to budge on the hemodialysis decision?” Harper sank into the resident lounge’s threadbare couch and kicked up her feet. “Nope.” Noah slumped in the chair across from her. It was late afternoon, and he’d almost finished checking off the tasks on
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Medical ethics dilemma: a hemodialysis decision originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - November 9, 2023 Category: General Medicine Authors: Jennifer Lycette, MD Tags: Conditions Nephrology Source Type: blogs
3D Printing In Medicine And Healthcare – The Ultimate List
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. See the impressive list of 3D-printed healthcare materials and medical equipment below!
How does 3D printing in medicine work?
3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained in our article on bioprinting here.
As technology evolves, researchers work on various solutions. For example, engineers from the University of Buffalo have ...
Source: The Medical Futurist - November 7, 2023 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine 3d printed biomaterial tissue engineering Video bioprinting GC1 Innovation Source Type: blogs
