Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
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Senolytic CAR T Cell Therapy Improves Health in Aged Mice
https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/
To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CISD2 Upregulation Reduces the Senescence-Associated Secretory Phenotype in Aged Skin
CISD2 expression declines with age, while upregulation of CISD2 expression has been shown in mice to improve liver function and extend life span. This strategy is expected to have broad effects on function in many tissues beyond the liver. At least some of those benefits result from an increase in the efficiency of the complex cell maintenance processes of autophagy, recycling damaged and unwanted proteins and cell structures. As is the case for other approaches to slowing aging that function via autophagy, CISD2 upregulation has the effect of reducing senescent cell burden and suppressing the harmful senescence-associated...
Source: Fight Aging! - February 2, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Too much fawning over Len Schaeffer?
By MATTHEW HOLT
There’s a lot of strum & dangst about the uptick in system utilization that has boosted hospital profits and hit Humana and United’s bottom line (But not so much Elevance’s). Kevin O’ Leary over at Health Tech Nerds brought this up today and I was reminded of this piece I wrote in 2006. And a big issue was, how much understanding and control do insurers have over the utilization in (and out of) their networks. So take a look at this piece and particularly, given the issues at the BUCAHs and at smaller players like Agilon, consider how much insurers actually know about spending...
Source: The Health Care Blog - February 1, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Health insurers Len Schaeffer Medicare Advantage Oldies Utilization Source Type: blogs
Urogynecologists tackle the stigma of incontinence
As a urogynecologist, my clinic is full of women with bothersome bladder issues. And while this likely does not appeal to you, curing incontinence is my favorite clinical endeavor. Urinary incontinence seems like a minor medical problem. After all, it isn’t heart disease or cancer. However, urinary incontinence has a dramatic and negative impact on
Read more…
Urogynecologists tackle the stigma of incontinence originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 30, 2024 Category: General Medicine Authors: Sarah Boyles, MD, MPH Tags: Conditions OB/GYN Urology Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A physician ’ s journey in Cuba reveals surprising faith and resilience [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join William Lynes, a urologist, as he shares his remarkable journey of a recent missionary trip to Cuba. Discover the challenges and triumphs faced by both the Cuban people and the mission team. Explore the profound faith and resilience of the Cuban population, and
Read more…
A physician’s journey in Cuba reveals surprising faith and resilience [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 28, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Source Type: blogs
Weekly Roundup – January 27, 2024
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
The Big Consult: Clinicians Who Entered Digital IT Speak About the Differences. For this four-part series, Andy Oram spoke to more than a dozen clinicians now working in IT roles. Most made the switch to broaden their impact on the industry, Andy learned. They also discussed lending their expertise to helping clinicians decide on the right technology. Re...
Source: EMR and HIPAA - January 27, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
A talk with Andy Bell on thriving with diabetes
Andy Bell:Experiencing diabetes beyond just numbers
I recently had the privilege of catching up with Andy Bell. A good friend and part of the diabetes community, Andy shared his story, which is packed with perseverance and resilience.Andy was diagnosed with type 1 diabetes in 1994 at the age of 14. His experience, like that of many others living with diabetes, has been a rollercoaster ride. During our conversation, Andy touched on his diagnosis story, how living with diabetes has impacted his life, his unique career path, and how he manages now that heâ€...
Source: Scott's Diabetes Blog - January 26, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
A Tour of Geroscience, Largely Focused on Unambitious Goals in the Treatment of Aging
Geroscience is a philosophy of development, suggesting that aging can be slowed and we should work towards means to do so. In practice, geroscience is, more or less, the the name given to that part of the research and development community that aims to produce means to alter metabolism to modestly slow aging. It is best represented by the development of supplements and repurposing of very well studied drugs, near all of which produce smaller benefits to long-term heath than regular moderate exercise, and none of which can match the benefits provided by the practice of calorie restriction. It is entirely unambitious. This l...
Source: Fight Aging! - January 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
GE HealthCare Announces Agreement to Acquire MIM Software
The Anticipated Acquisition Aligns to GE HealthCare’s Precision Care Strategy with the Goal of Strengthening the Company’s Digital Solutions Across Care Pathways
MIM Software Provides AI-Enabled Image Analysis and Workflow Tools Across Multiple Care Areas, Including Oncology, Urology, Neurology, and Cardiology
Today’s Agreement Reinforces GE HealthCare’s Commitment to Integrate Medical Imaging Products in Order to Deliver More Precise, Connected, and Efficient Care Across Disease States
GE HealthCare today announced it has entered into an agreement to acquire MIM Software, a global provider of medical imaging analy...
Source: EMR and HIPAA - January 25, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Andrew Nelson GE Healthcare Health IT Acquisitions Healthcare M&A MIM Software Peter Arduini Taha Kass-Hout Source Type: blogs
Reviewing the Potential for Klotho as a Basis for Therapy
Klotho is one of the few robustly longevity-associated genes discovered over the past few decades. Increased levels of the circulating α-klotho protein slows aging in mice and is associated with better late life health in humans. Additionally, more of this α-klotho appears to slow cognitive aging and also boost cognitive function in younger animals. While klotho is thought to be primarily active in the kidneys, and thus indicates the importance of declining kidney function in degenerative aging, researchers are discovering potentially relevant interactions in the brain. It remains an open question as to how exactly kloth...
Source: Fight Aging! - January 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What Do Fats Do in the Body?
It’s common knowledge that too much cholesterol and other fats can lead to disease and that a healthy diet involves watching how much fatty food we eat. However, our bodies need a certain amount of fat to function—and we can’t make it from scratch.
Hepatocytes, like the one shown here, are the most abundant type of cell in the human liver. One important role they play is producing bile, a liquid that aids in digesting fats. Credit: Donna Beer Stolz, University of Pittsburgh.
Triglycerides, cholesterol, and other essential fatty acids—the fats our bodies can’t make on their own—store energy, ins...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Common questions Source Type: blogs
HDL dysfunction & It ’ s clinical Implication
High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions .The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.(Article will be linked)
We know ,HDL carries free cholesterol from peripheral cells, including macrophages and endothelial cells. After reaching the liver, HDL receptors in the hepatocellular surface, metabolize it into bile acid or neutral lipids, which are ...
Source: Dr.S.Venkatesan MD - January 21, 2024 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Genetic Associations with Longevity are Stronger in Women
In this study, we discovered that genetic associations with longevity are on average stronger in females than in males through bio-demographic analyses of genome-wide association studies (GWAS) dataset of 2178 centenarians and 2299 middle-age controls of Chinese Longitudinal Healthy Longevity Study (CLHLS). This discovery is replicated across North and South regions of China, and is further confirmed by North-South discovery/replication analyses of different and independent datasets of Chinese healthy aging candidate genes with CLHLS participants who are not in CLHLS GWAS, including 2972 centenarians and 1992 middle-age co...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
