An Update on Reversal of Atherosclerosis at Repair Biotechnologies
As some of you know, Repair Biotechnologies is the company I co-founded with Bill Cherman back in 2018. We've been working on an approach to reverse atherosclerosis for much of that time, and matters have progressed through the stage of great data in mice to present preparations for a pre-IND meeting with the FDA. While excess cholesterol has long been understood to be important to the development of atherosclerosis, it turns out that circulating cholesterol bound to LDL particles is less important than the amount of localized excess cholesterol in the liver and blood vessel walls.
Any localized excess of cholestero...
Source: Fight Aging! - April 11, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Know About Cardiogenic Shock
When the heart is not able to pump enough blood for the needs of the body and the blood pressure falls, it is known as cardiogenic shock. Most important cause of cardiogenic shock is a heart attack. It is more likely to occur in those who are older, having blocks in multiple blood vessels of the heart, and in those with a previous heart attack. Cardiogenic shock is a potentially life threatening condition and needs urgent treatment. Even with treatment about half of those with cardiogenic shock might die.
Those with cardiogenic shock may have severe shortness of breath, weak pulse, rapid heart-beats, low blood pressure, un...
Source: Cardiophile MD - April 10, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
LyGenesis Commences Phase II Trial for Growth of Liver Organoids in Patient Lymph Nodes
LyGenesis has been working towards liver organoid transplantation as a treatment for liver failure for some years now. Organs such as the liver, thymus, and a few others do not need to be in any specific place in the body to carry out many of their varied functions. Some of the vital work of the liver, for example, can be conducted in small organoids grown from liver cells transplanted into lymph nodes or other parts of the body that can act as stable bioreactors.
Even setting aside the possibility of growing functional liver organoids from patient cells or universal cell lines, it is worth noting that the old appro...
Source: Fight Aging! - April 9, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
What is the reason for sudden breathlessness at night in those with heart disease?
Sudden breathlessness at night in those with known heart disease is usually due to collection of fluid in the lungs (pulmonary edema). During day time, when one is walking about, any extra fluid in the body tends to collect in the legs, due to the effect of gravity.
Extra fluid in the body can occur due to failure of heart, kidneys, liver and rarely due to other causes. In heart failure, the extra fluid is due to inability of the heart to pump out blood well. This can occur if the heart muscle is weak or there is obstruction to a valve regulating the flow of blood inside the heart.
At night, when one is lying down, extra f...
Source: Cardiophile MD - April 8, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Common pitfalls underlying cause-and-effect relationships
In the realm of medicine, cause-and-effect relationships are those where a specific cause, such as a disease, condition, or treatment, directly leads to a specific outcome or effect. An example of this is the established fact that smoking causes lung cancer. Similarly, it is well-documented that regular, heavy alcohol consumption directly leads to liver cirrhosis.
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Common pitfalls underlying cause-and-effect relationships originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 1, 2024 Category: General Medicine Authors: Arthur Lazarus, MD, MBA Tags: Physician Psychiatry Source Type: blogs
Bonus Features – March 31, 2024 – 55% of Change Healthcare customers expect adverse impacts on patient care, a mobile app helped 84% of seniors lower their blood pressure after 6 months, plus 19 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News
The State Department is offering a reward of up to $10 million for information about the ALPHV BlackCat ransomware-as-a-service group that was behind the Change Healthcare cyberattack.
A report from HFMA and Eliciting Insig...
Source: EMR and HIPAA - March 31, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT AdvancedMD Bitsight Carequality CENTEGIX CentralReach Closed Loop Medicine David Stevens Diligent Eliciting Insights Experity FrontRunnerHC Healthcare IT Today Bonus Features Hello Heart HFMA Incite Strategic Pa Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wide Complex Tachycardia -- VT, SVT, or A Fib with RVR? If SVT, is it AVNRT or AVRT?
A 69 y.o. male with pertinent past medical history including Atrial fibrillation, atrial flutter, cardiomyopathy, Pulmonary Embolism, and hypertension presented to the Emergency Department via ambulance for respiratory distress and tachycardia. Per EMS report, patient believes he has been in atrial fibrillation for 5 days, since coming down with flu-like illness with rhinorrhea, productive cough, SOB. Patient is on rivaroxaben, carvedilol, and dofetilide (to suppress atrial fib -- rhythm control). He states that he maybe missed a dose or two during recent illness. On EMS arrival, patient ' s oxygen sat...
Source: Dr. Smith's ECG Blog - March 28, 2024 Category: Cardiology Authors: Steve Smith Source Type: blogs
MKK4 Inhibition Provokes Greater Liver Regeneration
Researchers here report on an approach to meaningfully stimulate the regenerative capacity of the liver. The liver is one of the few organs capable of significant regrowth in mammals, and the way in which it does so is quite different from the regenerative response found in other tissues. Thus while the results here are quite impressive, they don't apply to other organs. This is purely a way to manipulate the regulation of liver regeneration.
One key feature of acute and chronic liver diseases, and after extended liver resections, is the inability of hepatocytes to sufficiently regenerate and restore or maintain a...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Estrogen-Related Receptor Agonists as Exercise Mimetic Drugs
Just as the research community is interested in finding pharmaceutical ways to provoke some the beneficial reactions to calorie restriction, there is also considerable effort devoted to the search for drug candidates that can mimic some of the benefits of exercise. If the history of calorie restriction mimetic drug development is any guide, this will be a slow process, and the resulting compounds will produce lesser benefits than actual exercise, as they will only touch on a small subset of the processes involved. Still, there is no shortage of programs in this space, and here is one example.
Exercise benefits bot...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
poem
The Un-Operative NoteI was not on call. I did not meet the 58 year old school teacher on her worst day. We did not review the films or a treatment plan. We did not discuss the risks and benefits of operative intervention. I did not drive in at 3 in the morning, half conscious, blasting the Strokes to wake the f. up. I did not make that vertical midline incision. Nor was I there to suction out a liter of foul contamination. I did not place those sutures to close the hole in her gut. It wasn ’t my decision to place a drain under the liver. I did not speak to the husband. Or console the teary eyed daughters whoâ...
Source: Buckeye Surgeon - March 25, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Physician mental health: Breaking the silence [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Pediatric nephrologist Katherine Twombley opens up about her personal journey and her book, First Do No Harm: A Physician’s Burnout and Mental Health Guidebook from Medical School to Retirement. Join us as she sheds light on the important topic of physician
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Physician mental health: Breaking the silence [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 24, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Primary Care Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Biatrial Enlargement on Chest X-Ray PA View
Transcript of the video: Chest X-ray PA view. You can see that there is straightening of left border. Normally, the main pulmonary artery segment will be concave and left atrial appendage region also will be not prominent. Here both have enlarged slightly, but not enough to produce gross bulges. So that is why we see straightening of left border, typically heard of in mitral stenosis with left atrial enlargement and mild pulmonary hypertension. When there is gross pulmonary hypertension, instead of these being straight over here, it will form a bulge over here. And when there is gross enlargement of left atrial appendage, ...
Source: Cardiophile MD - March 21, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
