Young Plasma from Pigs Reduces Epigenetic Age in Old Rats
One interesting question in the development of new epigenetic clocks to measure biological age, particularly now that a large consortium of researchers has published a universal mammalian clock, is how one demonstrates that a new clock is in some way useful enough or interesting enough to spend time on. There are, after all, many published clocks at this point, and we might expect that the research community will attempt to standardize on the new universal clock. Why use another novel clock? One answer might be that the clock is optimized to give a large signal under a particular set of circumstances. Hence we arrive at st...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What does statin do to Cholesterol absorbtion from Intestine ?
A.Reduces
B Increases
C.No effect
D. Iam not sure
Does this sound a difficult question ?
Many felt so. Hence, I decided to ask the all too popular AI machine.
It became a brief little chat with GPT, that surprised me .
https://chat.openai.com/share/6b96c54e-ad52-472a-9ebd-b7b1e1c762be
Statin: Some untold story.
Last century’s rockstar drug, statin do stimulate Cholesterol abosorbtion as well as hepatic synthesis.We must be aware, It is a less popularised truth (Intentionally ? ) among the cardiolgy community,
Ofcourse LDL comes down, at the cost of residual pre -choleterol particles th...
Source: Dr.S.Venkatesan MD - August 19, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
CareDx Acquires MediGO, an Organ Transplant Supply Chain and Logistics Company
MediGO Platform Aims to Improve Access to Donated Organs and Shorten Transplant Wait Times
Acquisition Expands CareDx Digital Health Portfolio and Establishes Footprint in OPO Market
CareDx, Inc., a leading precision medicine company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers — today announced the acquisition of MediGO, Inc. in a strategic move to expand its digital health portfolio to serve the organ procurement organization (OPO) market while also bolstering its pre-transplant offerings aimed at shorte...
Source: EMR and HIPAA - August 18, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT CareDx CareDx Inc. Dr. Joseph Scalea Health IT Acquisitions Healthcare M&A Medical University of South Carolina MediGO MediGO Inc. OPO Organ Transplant Reg Seeto Scott Plank Source Type: blogs
A letter that shook this urologist [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We delve into urologist William Lynes’ emotional journey as a physician grappling with burnout and the weight of medical decisions. A distressing note triggers introspection, unraveling the hidden turmoil of a healer. Join us to explore the intersection of duty and personal battles in
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A letter that shook this urologist [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 16, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Surgery Source Type: blogs
Raised Remnant Cholesterol Level Correlates with Frailty
Remnant cholesterol refers to circulating cholesterol in the bloodstream that is not attached to LDL transport particles coming from the liver or HDL transport particles going to the liver. The remnant is attached to some mix of VLDL and IDL particles that serve much the same purpose as LDL particles, or incorporated into much larger chylomicron transporters that carry dietary lipids from the intestines throughout the body.
Researchers have noted that remnant cholesterol appears to contribute to cardiovascular risk, speeding the progression of atherosclerosis and increasing the risk of stroke and heart attack. It is...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bacteriophages to Diagnose and Treat Bladder Infections
Researchers at ETH Zurich have developed a bacteriophage system to identify and treat bacterial bladder infections. Bacteriophages are viruses that infect bacteria, but these microorganisms have fallen out of favor as a treatment method for infection since antibiotics came along. Well, antibiotics are looking increasingly shaky as bacteria evolve to resist them, so researchers are returning to bacteriophages as a way to treat antibiotic-resistant infections. However, these Swiss-based researchers have turbo-charged bacteriophages by genetically modifying them so that they are more effective at killing bacteria, and also so...
Source: Medgadget - August 8, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health Urology bacteriophages ETH ETH_en Source Type: blogs
Shame behind the stethoscope [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We welcome William Lynes, a urologist, who shares his powerful and personal story. William opens up about his battle with burnout, mental illness, and multiple suicide attempts. From his successful career to the devastating medical events that changed everything, he reveals the shame he
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Shame behind the stethoscope [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 7, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Source Type: blogs
Bonus Features – August 6, 2023 – 83% of hospitals are collecting SDoH data, 46% of hospitals planning to use large language models in the call center, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Research
Five in six (83%) of hospitals are collecting SDoH data, according to the latest ONC Data Brief, with 74% using structured, electronic screening tools. Another 60% of hospitals are receiving SDoH data from out...
Source: EMR and HIPAA - August 6, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT ACO REACH AdvancedMD athenahealth Barracuda Cadence CareAR Carenet Health Cedar Clarify Health Cognizant Configo Health Connect Cost Plus Drugs David Bertoch David S. Wichmann Denise Ceule Dr. Mark Cohen e Source Type: blogs
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Visually Guided Uterine Biopsies in Physician ’s Office: Interview with Allison London Brown, CEO of LUMINELLE
LUMINELLE, a medtech company based in North Carolina, has developed a suite of endoscopic tools that allow clinicians to perform visually guided gynecological procedures right from their office. At present, the majority of uterine biopsies taken to investigate the cause of abnormal uterine bleeding are taken blind, with no visual guidance at all. This leads to suboptimal outcomes, and the frequent need to repeat the biopsy procedure because the first attempt did not yield an adequate sample.
To address this, LUMINELLE has developed the LUMINELLE SUSTAINE system and the LUMINELLE Bx (Biopsy) device. These technologies ar...
Source: Medgadget - August 4, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Ob/Gyn Source Type: blogs
Extracellular Vesicles from Young Cardiac Progenitor Cells Produce Benefits in Old Mice
The signaling environment in the body is generated by cells, communication mediated by the molecules that cells release and take up, many of which are packaged into extracellular vesicles. This signaling changes profoundly between development and adult life, and then again in important ways with advancing age. In principle, providing aged tissues with the signals passed back and forth during embryonic development will spur greater maintenance and regeneration. In practice, tissues are systems of great and only partially understood complexity, and attempts to beneficially manipulate signaling in this way are still very much...
Source: Fight Aging! - August 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Mitochondrial Transplantation as a Treatment for Kidney Damage
It is interesting see an increased focus on assessing the ability of mitochondrial transplantation to be useful in a variety of circumstances, not just as a treatment to reduce the mitochondrial dysfunction that occurs with aging. The limiting factor in bringing mitochondrial transplantation to the clinic is chiefly the speed at which the research and development communities can achieve the logistical advances needed to reliably produce enough mitochondria to deliver to an entire organ (at first), and the whole body (later). It is likely the case that mitochondria will have to be patient-matched by haplotype of mitochondri...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Complement-Producing Macrophages in Atherosclerosis
Atherosclerosis is, fundamentally, a condition centered around the function, capabilities, and age-related dysfunction of macrophage cells. These innate immune cells are responsible for clearing excess cholesterol, transported via LDL particles, from blood vessel walls. As macrophages become more dysfunctional with age, or otherwise shift in their activities due to rising inflammatory signaling, deposits of cholesterol can reach a tipping point at which they can no longer be cleared and turn into atherosclerotic lesions. Macrophages in the lesions are overwhelmed by the excess of cholesterol, become inflammatory, and die, ...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Heterochronic Parabiosis Produces Modest Extension of Life in the Older Paired Mouse
Heterochronic parabiosis is the surgical joining of the circulatory systems of an old and young mouse, both of the same genetic background. The younger mouse shows signs of accelerated aging, while the old mouse shows signs of rejuvenation. This has led to a broad range of research and development focused on age-related changes in levels of various signal molecules in the bloodstream. Some groups continue to look at declining levels of specific molecules such as GDF11 and oxytocin that might be boosted in old mice, but at present the consensus appears to be that old blood contains damaging signals, changing cell behavior f...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
In this study, we report systemic changes in the molecular regulation of biological processes under multiple lifespan-extending interventions, by jointly leveraging systems-level analyses on two mouse liver proteomic datasets, which were generated in the NIA Longevity Consortium, and a previously published mouse liver transcriptomic dataset. Differential Rank Conservation (DIRAC) analyses of mouse liver proteomics and transcriptomics data show that mechanistically distinct lifespan-extending interventions (acarbose, 17α-estradiol, rapamycin, and calorie restriction) generally tighten the regulation of biological modules. ...
Source: Fight Aging! - August 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
