Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
« Back to Top
Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Ambience Healthcare Raises $70M to Scale the Most Comprehensive AI Operating System for Healthcare Organizations
Ambience Healthcare, the most comprehensive AI operating system for healthcare organizations, has announced a $70M Series B raise co-led by Kleiner Perkins and OpenAI Startup Fund. The raise also includes existing investors Andreessen Horowitz and Optum Ventures.
“Healthcare is one of AI’s most promising opportunities to create an outsized positive impact on the world. Ambience Healthcare has built an incredible team to focus on providing a complete ecosystem of products that seamlessly fit into the workflow of practitioners, pushing both AI and medicine forward,” said Brad Lightcap, COO at OpenAI and...
Source: EMR and HIPAA - February 23, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT AdvancedMD Ambience Healthcare Andreessen Horowitz athenahealth Brad Lightcap Cerner Dr. Priti Patel eClinicalWorks eCW Elation Epic Eventus WholeHealth GI Alliance Health IT Funding Health Source Type: blogs
MTTP as a Mediator of the Benefits of Exercise
MTTP is a longevity-associated gene involved in lipid metabolism and correlated with cardiovascular function. Here, researchers use flies to demonstrate that the fly version of MTTP, called mtp, is involved in the mechanisms by which exercise improves long-term cardiac health. It isn't clear as to how exactly MTTP or mtp is involved in the known set of mechanisms important to the pace of aging and cardiovascular health. That sort of deep dive into establishing connections between cellular processes occurs only after numerous studies have demonstrated an interesting correlation, and even then it is a slow and incremental pr...
Source: Fight Aging! - February 22, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Popular Science View of Recent Thinking on DNA Damage as a Cause of Aging
There are presently two views of the way in which stochastic DNA damage can contribute to aging. Most DNA damage occurs in inactive genes in cells that will not replicate many more times, and thus cannot possibly produce systemic consequences throughout large regions of the body. The first argument for a way in which random DNA damage can produce a broader effect is via somatic mosaicism, in which mutational damage occurs in stem cells, allowing those mutations to spread throughout tissue over time. It is unclear as to how to measure the contribution of this process to age-related loss of function, however, and its contrib...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Gene Therapy to Promote Cardiomyocyte Proliferation Improves Late Stage Heart Failure in Rats
In this study, we did something that had not been done before. We intervened with the same gene therapy but not during acute heart failure or early in the disease as in our previous experiments, but late in the disease during the chronic phase four weeks after cardiac injury had severely damaged the heart."
Four months after treating the animals, the researchers checked cardiac function and heart structure. "We were surprised to see evidence of significant heart cell proliferation, a marked reduction in scar size and a significant improvement in cardiac function. Although heart dilation and lung congestion associate...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 19th 2024
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS.
We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 18, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Breakthroughs in liver cancer treatment [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! We sit down with health care executive Eugene Chan to explore the rising rates of liver cancer worldwide and the potential game-changer in its treatment: monoclonal antibodies. Join us as we delve into the factors contributing to liver cancer’s prevalence, the impact of vaccination,
Read more…
Breakthroughs in liver cancer treatment [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 17, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Oncology/Hematology Source Type: blogs
Why the Low Weight Group Exhibits Worse Outcomes in Some Epidemiological Studies
In this study, we first explored the association between WC, WHtR, and WWI change patterns and multimorbidity. WC and WHtR are considered to be important anthropometric indicators of abdominal obesity. Previous studies have suggested that WC and WHtR can reflect body fat percentage accurately and play an important role in predicting some chronic diseases, such as cardiovascular disease and metabolic syndrome. The pathway may explain that abdominal obesity significantly increased plasma triglycerides, low density lipoproteins, and very low density lipoproteins, which have been shown to increase the risk of adverse outcomes ...
Source: Fight Aging! - February 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Health Note Updates the Tired Old Patient Questionnaire
This article discusses the service provided by Health Note, which illustrates the capabilities of modern patient interaction using AI and integration with the EHR.
Even a standard questionnaire can advance us five minutes into a normal fifteen-minute interview. But Health Note can do much better. According to chief technical officer Aaron Rau, their service goes far beyond asking the conventional questions.
Health Note digs into the EHR, using AI, and combines the information found with its own medical knowledge to ask the questions a doctor would normally ask during a visit. “When did the pain start? Has it gotten b...
Source: EMR and HIPAA - February 16, 2024 Category: Information Technology Authors: Andy Oram Tags: AI/Machine Learning Ambulatory Communication and Patient Experience EMR-EHR Health IT Company Healthcare IT Aaron Rau Cedars-Sinai Digital Front Door EHR Integration Health Note Healthcare Generative AI Healthcare LLMs Hyung Kim Source Type: blogs
Let ’ s Think of Patient-Centered Care, Not Value-Based Care
This article explores some fundamental changes that could accompany this shift in terminology, revolutionizing how we handle data and patient interventions.
Engagement For Life
We know that maintaining health is an endeavor that takes years, even decades. A successful endeavor must survive the departure of clinicians who have built relationships with the patient, as well as the patient’s own geographic moves, changes of provider, and changes of insurance. Treatment recommendations should also be tailored to the psychology of each patient.
Is there a message in this exhortation for people working with data and healt...
Source: EMR and HIPAA - February 13, 2024 Category: Information Technology Authors: Andy Oram Tags: Analytics/Big Data C-Suite Leadership Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Interoperability Chronic Care Management Patient Centered Care Patients Society for Participatory Medic Source Type: blogs
Considering the Near Future of Senotherapeutics
Senescent cells accumulate with age, and this accumulation drives a sizable fraction of the dysfunction of degenerative aging. While never present in very large numbers, these cells energetically secrete signal molecules that provoke inflammation and tissue remodeling. As noted here, a major theme in the development of senotherapeutic drugs to either selectively destroy senescent cells or broadly suppress the disruptive signaling of senescent cells is the need for greater understanding of the diversity of cellular senescence. Different tissues, different cell types, different origins of the senescent state may all be meani...
Source: Fight Aging! - February 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
« Back to Top
Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
There ’s no place like home when it comes to health care, except for those who fall through the cracks
Maria (name changed to protect patient privacy) is a brilliant woman with a troubled health history. After a mental health diagnosis cut short her career as a high-level government official, Maria has struggled with diabetes, peripheral neuropathy, depression, and advanced kidney disease, leading to a series of toe amputations and a decade of disability. She
Read more…
There’s no place like home when it comes to health care, except for those who fall through the cracks originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 9, 2024 Category: General Medicine Authors: Gary Marc Rothenberg, DPM Tags: Conditions Primary Care Source Type: blogs
Bypassing Causes to Focus on Repairing Damaged Synapses in Alzheimer's Disease
Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer's disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems that ultimately kill neurons, not just damage them, it seems possible that synaptic repair might do well in the early stages of cognitive impairment, but later do little to help as the condition progresses. Regardless, it is interesting to consider to degree to which neural function ...
Source: Fight Aging! - February 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Novel HDAC1/2 Inhibitor Improves Measures of Tissue Function in Aged Mice
Researchers here report on the results of a drug screen focused on mimicking the transcriptional changes that occur in a number of interventions shown to modestly slow aging in short-lived species. They find an inhibitor of histone deacetylases HDAC1 and HDAC2 achieves this outcome, and note that in mice this drug candidate can produce positive changes in a number of measures of tissue function. Further studies will have to explore longer-term effects, dosing, and side-effects. Histone decacetylases influence the structure of the nuclear genome, and thus also influence gene expression quite broadly. Understanding how and w...
Source: Fight Aging! - February 7, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
