A Study of Metabolite Profiles in Healthy Individuals Across Age Groups
In today's open access paper, researchers report on a study of age-related changes in metabolite profiles in blood, muscle, and urine, with samples taken from healthy members of age groups spanning the 20s to 80s. As might be expected, the results point to many of the usual suspects in aging, such as senescent cell burden and mitochondrial dysfunction.
It is certainly possible to use metabolomic data to construct aging clocks in much the same way as for epigenetic data, and some researchers have done just that in recent years. There are indeed characteristic changes in a range of metabolite levels that appear to ref...
Source: Fight Aging! - July 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Medical reparations are long overdue in medicine
The Philadelphia Inquirer has been covering health inequities and potential remedial solutions for years. One recent story described how a new policy requires that patients’ kidney function be estimated without taking their race into account, highlighting the case of a Black woman whose kidney transplant was delayed five years because the medical center relied on
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Medical reparations are long overdue in medicine originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 5, 2023 Category: General Medicine Authors: Arthur Lazarus, MD, MBA Tags: Policy Public Health & Policy Source Type: blogs
Unmasking physician burnout: a survivor ’ s story and solutions for a healthy medical profession
I am a physician, a urologist, but what most people don’t know about me is that I am a survivor of mental illness, physician burnout, and multiple suicide attempts. Today, I write about the condition of the medical profession, its problem with burnout, and its solutions. I began practicing general urology in 1987. My subsequent
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Unmasking physician burnout: a survivor’s story and solutions for a healthy medical profession originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 3, 2023 Category: General Medicine Authors: William Lynes, MD Tags: Physician Psychiatry Source Type: blogs
A urologist ’ s reflection on suicide and emotional anguish [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join us for a thought-provoking podcast episode with guest William Lynes, a urologist, as we delve into the depths of a poignant message that left a lasting impact. Explore the story of Mr. G, a patient who tragically took his own life, prompting William
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A urologist’s reflection on suicide and emotional anguish [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - July 2, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Source Type: blogs
Fight Aging! Newsletter, July 3rd 2023
In this study, cultured adipose-derived stem cells (ASCs) were derived from subcutaneous white adipose tissue isolated from mice fed a normal diet. We performed senescence-associated-β-galactosidase (SA-β-gal) staining, real-time PCR, and Western blot to evaluate the levels related to cellular senescence markers.
The mRNA expression levels of senescence markers were significantly increased in the later passages of ASCs. We show that light activation reduced the expression of senescent genes, and SA-β-Gal in all cells at passages. Moreover, the light-activated ASCs-derived exosomes decrease the expression of senes...
Source: Fight Aging! - July 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rat Kidneys Vitrified, Warmed with Magnetic Nanoparticles, then Transplanted Successfully
Another step forward for the magnetic nanoparticle approach to thawing vitrified tissues was recently reported. Vitrification for low-temperature storage is a fairly well established technique, at least for organs. The challenge lies in thawing vitrified organ tissue without causing so much damage that it becomes non-viable for transplantation. Researchers have now managed to make this work for rat kidneys, albeit just barely. The kidneys were damaged, and it remains the case that scaling up to human organs will have its challenges. A greater volume of tissue makes cryopreservation and later thawing much harder, but succes...
Source: Fight Aging! - June 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
If Probiotics in their Present Form Were a Truly Effective Intervention, We Would Already Know
There is an increasing focus in the research community on the role of the gut microbiome in aging. This is in large part driven by the ability to accurately, cost-effectively measure the composition of the gut microbiome from a stool sample, using 16S rRNA sequencing. The 16S rRNA gene is differs between bacterial species, without being subject to a high rate of mutation and change. Using low-cost modern techniques, researchers can thus read out the relative numbers of different species in the gut microbiome, a service now available to the public at large as well. This allows researchers to see exactly how the balance of p...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
From physician to survivor: My inspiring journey through burnout, mental illness, and triumph
I am a physician, specifically a urologist. However, what most people do not know about me is that I am a survivor of multiple suicide attempts. My essay attempts to tell my personal story—a story of burnout, mental illness, and suicide—and to discuss the shame that accompanied these experiences. I completed my urologic residency in
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From physician to survivor: My inspiring journey through burnout, mental illness, and triumph originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 26, 2023 Category: General Medicine Authors: William Lynes, MD Tags: Physician Psychiatry Source Type: blogs
Metabolic Disorders Increase the Burden of Cellular Senescence
Why do patients with metabolic disorders such as obesity and type 2 diabetes exhibit what appears to be an accelerated progression of aging, such as increased risk of disease, shorter life expectancy, and so forth? One increasingly well established candidate mechanism is the presence of a greater burden of senescent cells, these cells generating chronic inflammation and harmful alterations to the behavior of other cells via their secretions. Senolytic therapies to clear these senescent cells may prove to be a first step towards decoupling obesity from the consequences of obesity, but there are numerous other ways in which ...
Source: Fight Aging! - June 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
From darkness to healing: a urologist ’ s journey through suicidal ideation [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! In this poignant podcast episode, we welcome guest William Lynes, a urologist and survivor of physician burnout, who shares his personal journey through multiple suicide attempts. Join us as we delve into the four stages of suicidal ideation and the complex evolution of thoughts
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From darkness to healing: a urologist’s journey through suicidal ideation [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 25, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Source Type: blogs
Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models.
The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Can You Drink Licorice With Hypertension?
Conclusion
It’s clear that licorice, with its potent compound glycyrrhizin, can potentially raise blood pressure. This makes it a food item to approach with caution for those living with hypertension. But, remember, not all “licorice” you see on shelves contains real licorice root or extract. Checking labels can help identify those sneaky substitutes.
Moderation and informed choices are your allies. While occasional licorice consumption might be fine for some, it’s always best to consult your healthcare provider to ensure you’re not jeopardizing your well-being.
Delicious alternatives...
Source: The EMT Spot - June 24, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Can You Drink A Juice Cleanse With Hypertension?
Conclusion
Navigating the crossroads of popular health trends and chronic conditions can be challenging. So, can you drink a juice cleanse with hypertension? Yes, but with an asterisk. The nature of the cleanse, your individual health, and the involvement of healthcare professionals all play a pivotal role.
The answer lies in striking the right balance – not too much sodium or sugar, an eye on potassium levels, and regular monitoring of blood pressure. As the experiences of Mark, Sarah, and John demonstrated, the journey is unique for everyone.
In the words of Dr. Naomi Fisher at Harvard Medical School:
...
Source: The EMT Spot - June 23, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
How one liver disease patient found hope and overcame adversity
The first day I came to the liver service, I met Mr. S, who was struggling with complications of liver disease. In the long term, he required a TIPS procedure that would better distribute his abdominal pressure and eventually a liver transplant. He was at high risk for the procedure and was struggling to maintain
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How one liver disease patient found hope and overcame adversity originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 22, 2023 Category: General Medicine Authors: Johnathan Yao, MD, MPH Tags: Conditions Gastroenterology Source Type: blogs
6 Dangers And Risks Of Low Blood Pressure
Conclusion
Low blood pressure (hypotension) may not be as prominent or noticeable as hypertension, but it can still have significant impacts on various organs over time.
Unlike hypertension, hypotension is often only clinically considered and treated when it reaches a life-threatening condition called shock, requiring emergency care.
Low blood pressure can result in adverse effects such as insufficient blood flow to the brain, compromising cognitive function, and leading to dizziness.
The heart may struggle to pump blood effectively, resulting in chest pain and irregular heart rhythms. Kidney function can be im...
Source: The EMT Spot - June 22, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
