CLEAR Trial of Bempedoic Acid
Bempedoic acid is an ATP citrate lyase inhibitor, acting upstream of HMGCoA reductase targeted by statins, and reduces LDL cholesterol levels. It is associated with low incidence of muscle related adverse events compared to statins. US FDA had a prerequisite that patients should be already on maximally tolerated stating therapy before considering bempedoic acid and had noted that their effect on cardiovascular morbidity and mortality were considered as indeterminate. The manufacturers have reported that these clauses have been removed.
The CLEAR (Cholesterol Lowering via Bempedoic Acid [ECT1002], an ACL-Inhibiting Regime...
Source: Cardiophile MD - December 16, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Changes in the Gut Microbiome Correlate with Aging and Renal Function
The gut microbiome changes with age. Pro-inflammatory microbial populations grow in size at the expense of populations that produce beneficial metabolites. As researchers produce increasingly large databases of the composition of the gut microbiome across ages and populations, they are also mapping a growing number of specific connections between microbial species and aspects of aging. Some of this work shows causation, but most human data can only show correlations between aspects of the gut microbiome and aspects of aging. In today's open access paper, the authors focused on finding links between the gut microbiome and t...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Resolvin D2 Treatment Increases Monocyte Production and Slows Liver Aging in Mice
Researchers here report on their exploration of a way to adjust the production of monocytes in the bone marrow, cells that become macrophages of the innate immune system. This is chiefly interesting for the lasting effect that a single treatment appears to have on the progression of liver aging in mice, leading to reduced pathology connected to inflammation, such as fibrosis. Also interesting is that providing aged bone marrow to young mice accelerates this liver pathology, by altering the generation of macrophages in the direction that induces liver pathology. Fibrosis is the excessive generation of collagen structures in...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Building Aging Clocks for Specific Organs from Circulating Protein Levels
As illustrated by the last decade or so of research, any sufficiently complex set of biological data can be mined via machine learning to produce algorithms that report chronological age and incorporate some sensitivity to biological age. Biological data changes over time, and many of those changes are characteristic of age. The processes and dysfunctions of age touch on all mechanisms in the body, given time. The hypothetical perfect measure of biological age would accurately predict mortality risk, and be a comprehensive reflection of the burden of damage and dysfunction resulting from processes of aging. That may be imp...
Source: Fight Aging! - December 14, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Klotho Levels Decline with Age, But Are Unaffected by Physical Fitness at a Given Age
Klotho is a longevity-associated gene. Klotho functions within the cell, but a portion of the full protein is also released into the bloodstream. In humans, higher levels of circulating klotho correlate with lower incidence of age-related disease and mortality. In mice, interventions such as gene therapies that increase klotho levels have been shown to extend life, while reducing klotho levels shortens life. Klotho is thought to act within the kidney, where it is protective, slowing age-related decline of kidney function. Increased klotho levels produce cognitive improvement in mice and non-human primates, however, and hig...
Source: Fight Aging! - December 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The NIA Interventions Testing Program Shows that Fisetin Does Not Extend Life in Mice
The latest results from the NIA Interventions Testing Program (ITP) were recently published. The ITP conducts the most rigorous of animal life span studies, frequently demonstrating that earlier promising results were incorrect. The most interesting outcome from this batch of different interventions is that fisetin, demonstrated to clear senescent cells in mice and improve health measures, did not extend life. In contrast, dasatinib and quercetin, the most well-studied senolytic, has been shown by other groups to extend life in mice, by 36% in one study. This is puzzling!
We might theorize that either fisetin at th...
Source: Fight Aging! - December 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Current State Of Almost 700 FDA-Approved, AI-Based Medical Devices
The rise of Artificial Intelligence (AI) and Machine Learning (ML) in healthcare has reshaped the industry. And due to the recent march of ChatGPT, Midjourney and similar tools, various AI algorithms have entered the lives of the general population as well. These technologies will undoubtedly change the way medicine is practiced. Given that healthcare is an industry where decisions can literally be a matter of life and death, the importance of effective regulation can’t be overstated. Now this is one hell of a challenge even for the most seasoned professionals.
AI and ML present novel regulatory challenges. Unlike...
Source: The Medical Futurist - December 12, 2023 Category: Information Technology Authors: Andrea Koncz Tags: Artificial Intelligence in Medicine AI digital health fda Healthcare AI in healthcare AI in medicine AI-based medical devices Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
« Back to ...
Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Cellular Senescence in Pulmonary Fibrosis
The first small human clinical trial of the senolytic therapy of dasatinib and quercetin targeted idiopathic pulmonary fibrosis, showing some benefit to patients. Later trials for kidney disease demonstrated that this treatment does remove a fraction of lingering senescent cells in human tissues in much the same way as it does in mice. Senescent cells accumulate with age in tissues throughout the body, the burden of these cells resulting from a growing gap between pace of creation and pace of clearance by the immune system. Researchers are coming to see a prominent role for senescent cells in all fibrotic conditions, in wh...
Source: Fight Aging! - December 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
From ICU to kidney mass: a nurse ’ s journey of fear
After 32 years working as an ICU nurse, I believed I had developed a strong capacity to confront death alongside my patients. I had become accustomed to the challenging scenarios: co-morbidities, multi-system organ failure, emergency intubations, ventilators, pressors, central lines, art lines, failure-to-thrive cases, code blues, and the grim sounds of ribs cracking during CPR.
Read more…
From ICU to kidney mass: a nurse’s journey of fear originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 6, 2023 Category: General Medicine Authors: Debbie Moore-Black, RN Tags: Conditions Oncology/Hematology Source Type: blogs
Klotho as a Biomarker of the Influence of Lifestyle Choice on Health
Klotho is a longevity-associated protein that operates both within the cell and also as a circulating signal protein. It is longevity-associated in the sense that upregulation increases life span and downregulation reduces life span in mice, but also in the sense that measured klotho levels correlate with health and life expectancy in human epidemiological studies. Klotho may largely operate by maintaining kidney function into late life, but researchers have found that it may also help brain cells resist the harmful effects of an aged environment.
In today's open access paper, the authors make the interesting point ...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Navigating physician shortages in rural communities
In the rural area where I practice, two general surgeons recently retired, a medical oncologist moved out of the community, and two urologists left over a year ago. My patients with cancer are left wondering who will care for them. And this small community is not alone. An aging physician population, burnout, and understaffing of
Read more…
Navigating physician shortages in rural communities originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 5, 2023 Category: General Medicine Authors: Stacy Wentworth, MD Tags: Physician Oncology/Hematology Source Type: blogs
Muscle TFEB Overexpression Slows Cognitive Aging in Mice
Muscle tissue is metabolically active, and affects the operation of other organs. At this time, a good map of the important signals that pass between muscle and other tissues has yet to be created. Maintenance of muscle mass and function in later life clearly produces a more systemic benefit than simply postponing weakness and frailty, but the details of the biochemistry are not well understood. Thus researchers can perform muscle-specific interventions in animal models, such as the one noted here, show a slowing of cognitive aging to result from that intervention, but not have a good grasp of how exactly how the altered m...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Most Overhyped Technologies in Healthcare
The hype about technological development in healthcare should not blind us in terms of the probabilities and possibilities of today’s healthcare and the future of medicine. To remain objective and conscious but still optimistic, let’s look at the most overhyped technologies and keep in mind the realistic development opportunities in healing.
You know the saying: the pessimist says the glass is half empty, the optimist says it is half full, and, well, the cynic asks who drank the other half? I’m truly an optimist – especially when it comes to the future of medicine and healthcare, but we need to ask the uncom...
Source: The Medical Futurist - December 5, 2023 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine 3d printing robotics virtual reality wearables GC1 hype organs Source Type: blogs
