Is Transfusion of Young Blood Essentially a Form of Extracellular Vesicle Therapy?
In this study, we examined the effect of young serum on the cognitive performance of aged mice. We show that repeated infusions with small volumes of young serum significantly improved age-associated memory deficits and this effect was abrogated after the serum was depleted of circulating EVs. RNA-seq analysis of choroid plexus demonstrated effects on genes involved in barrier function and trans-barrier transport. Interestingly, the hippocampal transcriptome demonstrated a significant upregulation of Klotho (Kl) gene, which codes for the longevity protein Klotho, following young serum treatment. Notably this effect was abr...
Source: Fight Aging! - September 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Bonus Features – September 3, 2023 – 60% of cybersecurity incidents impact patient care, the average medical device has six or more security vulnerabilities, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
News and Research
ONC renewed its contract for The Sequoia Project to be the Recognized Coordinating Entity for TEFCA implementation. That process will involve working with seven current Qualified Health Information Network can...
Source: EMR and HIPAA - September 3, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT AION Biosystems Akshay Sharma Alexander Group American Telemedicine Association Asimily ATA Atropos Health BeMe Health Carenet Health Claroty Cognizant Craig Hovda Digital Medicine Society eClinicalWorks eCW E Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Featured Health IT Job: Imaging System Analyst
We like to regularly feature a healthcare IT job that might be of interest to readers. Today, we’re featuring the Imaging System Analyst position that was recently posted on Healthcare IT Central. This position was posted by Llyod Staffing and is remote.
Here’s a description of the position:
Has minimum 3 years’ experience in previous support of Endoscopy imaging, Ophthalmology imaging, Urology imaging systems
Knowledge of Radiology and Cardiology PACS systems
Advanced knowledge of a VNA, preferably Hyland Mail Reader and PACS Gear MDR
Dicom modality interface troubleshooting
Knowledge and experience with ...
Source: EMR and HIPAA - August 30, 2023 Category: Information Technology Authors: Health IT Jobs Tags: Career and Jobs Healthcare IT Analyst Jobs Health IT Jobs Health IT Procurement Healthcare IT Jobs Imaging System Analyst Job Seekers Llyod Staffing Source Type: blogs
Is a PSA test right for me? A urologist answers.
“Should I get a PSA?” It depends. Who is asking, and why? If the question is being asked by a 45-year-old man, the answer is going to be different than if it’s being asked by a 75-year-old. If a primary care clinician is asking, he/she may be confused about current recommendations regarding screening for prostate
Read more…
Is a PSA test right for me? A urologist answers. originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 29, 2023 Category: General Medicine Authors: Stephen Lieberman, MD Tags: Conditions Urology Source Type: blogs
Physical Fitness Correlates with a Lower Risk of Atrial Fibrillation and Stroke
As one might expect, people who better maintain physical fitness into later life exhibit lesser degrees of age-related disease. In this case, the correlation is specifically for forms of cardiovascular disease, but researchers have reported that numerous other improvements in health can be linked to greater fitness. Animal studies can and do show causation in this relationship between fitness and age-related disease. It is reasonable to believe that the human correlations also largely reflect a causal relationship. There are a great many good reasons to make the effort to better maintain physical fitness throughout life.
...
Source: Fight Aging! - August 29, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Can You Take Creatine If You Have High Blood Pressure?
Conclusion
We’ve journeyed through the multifaceted world of creatine, from its role in boosting athletic performance to its potential therapeutic uses. We’ve also delved into the crucial relationship between creatine and high blood pressure, highlighting the need for caution.
The key takeaway? If you have high blood pressure, consult a healthcare provider before taking creatine. It’s not just a supplement; it’s a substance that interacts with various bodily functions and can have significant implications for your health.
So, before you consider adding creatine to your routine, make t...
Source: The EMT Spot - August 29, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, August 28th 2023
In conclusion, we identified 20 genes with significant evolutionary signals unique to long-lived species, which provided new insight into the lifespan extension of mammals and might bring new strategies to extend human lifespan.
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Trials of Xenotransplantation of Pig Organs into Humans Continue
https://www.fightaging.org/archives/2023/08/trials-of-xenotransplantation-of-pig-organs-into-humans-continue/
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants i...
Source: Fight Aging! - August 27, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Solutions for physician burnout [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join William Lynes, a urologist, as he shares his remarkable journey from a successful medical career to battling mental illness and physician burnout. With over three decades of experience, he delves into the root causes of burnout within the medical profession and unveils his
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Solutions for physician burnout [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 26, 2023 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Psychiatry Source Type: blogs
Red Blood Cell Extracellular Vesicles Assist Macrophages in Atherosclerotic Plaque
In this study, we investigated the uptake of RBCEVs by macrophages. We also monitored the intracellular trafficking of RBCEVs and the fate of haemoglobin, their most abundant protein cargo. We found that RBCEVs were preferentially taken up by macrophages in the liver and spleen. The EVs then released heme into the cytoplasm via the heme transporter HRG1, which promoted the differentiation of the macrophages to a phenotype characterized by upregulated HO-1 expression, and prevented the accumulation of oxidized low-density lipoproteins (oxLDL) in these cells. This natural therapeutic characteristic of RBCEVs suggests their p...
Source: Fight Aging! - August 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Trials of Xenotransplantation of Pig Organs into Humans Continue
Researchers have genetically engineered pigs to overcome the known barriers to transplantation of pig organs into humans, and have reached the stage of conducting transplants into terminally ill volunteers and brain dead individuals who donated their bodies to science. To learn by doing is really the only practical way by which the presently unknown problems are discovered. This trial of kidney transplantation ran for longer than prior efforts, and is a step on the path to producing a ready supply of non-human organs for transplantation, a technology that will compete with efforts to grow new organs on demands.
Su...
Source: Fight Aging! - August 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lipid Metabolism in Age-Related Disease
In this age of excess calories, in which a large proportion of the population is significantly overweight, research into lipid metabolism in the context of aging tends overlap with research into lipid metabolism in the context of obesity. People of normal weight still undergo complex changes in lipid metabolism and lipid transport throughout the body with age, however. These lead to prominent, important issues such as atherosclerosis, localized excesses of cholesterol and associated lesions in the arterial walls, for example. Looking at these conditions through the lens of lipid metabolism is looking at just one part of a ...
Source: Fight Aging! - August 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Drug Delivery System for Ectopic Pregnancy
Researchers at Oregon State University have developed a drug delivery system that is intended to treat ectopic pregnancy. Often occurring in the fallopian tubes, ectopic pregnancies are non-viable and are the leading cause of maternal death in the first trimester. A drug called methotrexate can be administered to end the pregnancy, but can cause serious side-effects at the concentrations required. These researchers designed a nanoparticle delivery vehicle for methotrexate that can release its drug payload near where it is needed by responding to glutathione, a tripeptide that is present in high concentrations in placental ...
Source: Medgadget - August 22, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Ob/Gyn Source Type: blogs
Reviewing the Aging of the Adrenal Gland
The smaller organs of the body tend to receive less attention from scientists in the field of aging research. There is a lot of ground to cover and only so many research groups. Attention is first given to better studied tissues with proven, direct connections to better studied diseases and causes of mortality. This includes the larger organs such as heart, lungs, liver, and so forth. Chemical factories and cell factories such as the adrenal gland and thymus are clearly important in aging, but indirect effects spread across many different age-related conditions are, it seems, more difficult to study and more difficult to o...
Source: Fight Aging! - August 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
