CCR Grand Rounds: Glypicans as Cancer Targets for CAR-T Immunotherapy
CCR Grand Rounds “ Glypicans as Cancer Targets for CAR-T Immunotherapy ” Mitchell Ho, Ph.D.Senior Investigator& Deputy ChiefLaboratory of Molecular BiologyCenter for Cancer Research, NCIFriday, April 19, 202412:00 – 1:00 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.Dr. Mitchell Ho is a Senior Investigator and Deputy Chief of the Laboratory of Molecular Biology and Director of the Antibody Engineering Program at the Center for Cancer Research, NCI. Dr. Ho's research encompasses investigating molecular mechanisms by which glypicans such as GPC1, GPC2 and GPC3 regulate Wnt signaling, as well as d...
Source: Videocast - All Events - April 15, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding the Biological Mechanisms Underlying the Health Consequences of Racism, Marginalization, and Discrimination - DAY 2
To convene people from diverse populations living with or at risk for diabetes and digestive and kidney diseases and conditions, as well as researchers and clinicians from across disciplines, to understand the state of the science and identify opportunities for considering common biological pathways underlying the consequences of racism, marginalization, and discrimination across population groups and disease areas. The focus on interdisciplinary research is intended to foster the cross-pollination of ideas and shared learning, as well as to promote consideration of intersectionality across marginalized identities and the ...
Source: Videocast - All Events - April 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding the Biological Mechanisms Underlying the Health Consequences of Racism, Marginalization, and Discrimination
The marginalization of groups based on socially constructed categories of race, ethnicity, sexual orientation, gender, and other identities produces biological consequences that contribute to health disparities in a variety of diseases and conditions, including many under the purview of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). For example, substantial racial and ethnic disparities exist in obesity, diabetes, and end-stage kidney disease. Racism, marginalization, and discrimination (RMD) is embedded into the structure of American society, which increases exposure to adverse social determ...
Source: Videocast - All Events - February 21, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
CDH1-Associated Hereditary Diffuse Gastric Cancer In A Child
Jeremy Davis, MDStaff ClinicianSurgical Oncology ProgramNational Cancer InstituteLouis Korman, MDAttending Clinician, Digestive Diseases BranchNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Sun A Kim, MD, MS, PhDStaff Pathologist& Assistant Research PhysicianSurgical and Digestive System PathologyLaboratory of PathologyNational Cancer InstituteGrace-Ann Fasaye, MDGenetic CounselorGenetics BranchCenter For Cancer ResearchNational Cancer InstituteFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 2/28/2024 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 2, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Chronic psychological stress and macrophage inflammation in atherosclerosis
Atherosclerosis is recognized as a chronic inflammatory disease of the arteries that initiates through normal protective functions of the innate immune system, but goes awry through the failure to resolve macrophage inflammation in the arterial plaques. Dr. Fisher ’ s laboratory has pioneered multiple mouse models in which to study inflammation resolution in atherosclerosis. He has collaborated with a number of colleagues to apply these models to study mechanisms by which certain conditions, such as diabetes, kidney disease, and obesity, increase cardiovascular risk through their interference with plaque macrophage infla...
Source: Videocast - All Events - February 1, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NHLBI Obesity, Nutrition, and Physical Activity Seminar: Dietary Biomarkers and Cardioprotective Mechanisms of the DASH Diet
In this one-hour webinar, Dr. Casey M. Rebholz, PhD, MS, MNSP, MPH, FAHA, will present an overview of “ Dietary Biomarkers and Cardioprotective Mechanisms of the DASH Diet ” She will discuss biomarkers as an objective approach to assess dietary intake. Dr. Rebholz will also present findings on metabolomic and proteomic biomarkers of the DASH dietary pattern from observational studies as well as clinical trials. Finally, she will share metabolomic markers of blood pressure reduction in response to the DASH diet. Dr. Rebholz is a tenure-track Associate Professor in the Department of Epidemiology at Johns Hopkins Bloombe...
Source: Videocast - All Events - January 31, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH ProtIG Seminar: The role of long-lived proteins in aging and Alzheimer ’ s disease
Loss of proteostasis is a hallmark of aging, and aging is the greatest risk factor for Alzheimer's disease (AD). Deterioration in function and accumulation of damage to the proteome are largely repaired by protein turnover. These turnover mechanisms are particularly important in long-lived postmitotic neurons, which cannot dilute toxic proteins through cell division. We aimed to identify extremely long-lived proteins (ELLP) that persist for several months or longer across the aging continuum in wild-type mice and in genetic AD mouse models. We hypothesize that these ELLPs represent key points of vulnerability to the declin...
Source: Videocast - All Events - November 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds: Immunotherapy of Liver Cancer: From Bench to Bedside and Back to the Bench
CCR Grand Rounds“ Immunotherapy of Liver Cancer: From Bench to Bedside and Back to the Bench ”
Tim F. Greten, M.D.
Deputy Chief, Thoracic and GI Malignancies Branch
Co-Director, NCI CCR Liver Cancer Program
Center for Cancer Research, NCI
Dr. Greten is a physician-scientist who uses his medical expertise in gastroenterology, hepatology and medical oncology along with his research expertise in tumor immunology to develop novel treatments for patients with cancer. He heads a research team to study the tumor microenvironment in the li ver in the context of hepatocellular carcinoma, cholangiocarcinoma and liver metasta...
Source: Videocast - All Events - September 13, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NSF-supported researchers have successfully transplanted an organ after cryopreservation.
Engineers and medical researchers at NSF's Engineering Research Center for Advanced Technologies for Preservation of Biological Systems have successfully cryopreserved a kidney for up to 100 days.This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - June 28, 2023 Category: Science Source Type: video
Clinical Center Grand Rounds: Biology of Aging and Longevity
2023 Distinguished Clinical Teaching Award
John Laws Decker Lecture
Co-Sponsored by Foundation for the National Institutes of Health Contemporary Clinical Medicine: Great Teachers Biology of Aging and Longevity Sriram Gubbi, MD Staff Clinician Principal Investigator, Functional Thyroid Disorders Thyroid Tumors and Functional Thyroid Disorders Section Metabolic Diseases Branch National Institute of Diabetes and Digestive and Kidney Diseases, NIDDKFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 6/7/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 5, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Getting to the “ Heart ” of Cardiometabolic Health Disparities
NIH Director ’ s Wednesday Afternoon Lecture Series
Annual Robert S. Gordon Jr. Lecture
Cardiometabolic diseases, including cardiovascular disease, diabetes, and chronic kidney disease, are exceedingly common and are collectively considered the leading causes of death worldwide. In this lecture, Dr. Lisa Cooper will describe the current state of cardiometabolic health disparities among adults in the United States. She will then discuss how interventions to reduce cardiometabolic health disparities are designed, implemented, and evaluated, and how these interventions address contributors to disparities at multiple levels...
Source: Videocast - All Events - May 15, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - IL-15-induced bystander T cell activation in human viral disease.
Dr. Eui-Cheol Shin investigates mechanisms of immunopathogenesis, immunosenescence, T-cell exhaustion, and human immune monitoring. Dr. Shin and his team have extensively demonstrated the pathological significance of bystander T cell activation in human disease by studying T cell responses in patients infected with viral diseases. His group has found that pre-existing bystander memory CD8+ T cells are unexpectedly activated by cytokines (e.g., IL-15) regardless of their antigen specificity, causing liver cell damage through NKG2D-mediated cytotoxicity. In characterizing IL-15-responsive bystander T cells in the liver micro...
Source: Videocast - All Events - May 11, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Multimodal decoding of liver regeneration and repair
Neil Henderson, Professor of Tissue Repair and Regeneration at the University of Edinburgh, is an academic hepatologist with an international profile in defining cellular interactions and molecular pathways driving organ fibrosis. Organ fibrosis (scarring) is a major cause of morbidity and mortality worldwide, and as yet there are no effective anti-fibrotic treatments. Dr. Henderson is primarily interested in the cellular and molecular mechanisms that drive organ fibrosis, and the pathways which are responsible for efficient wound healing and healthy tissue regeneration following injury. Dr. Henderson and his group have de...
Source: Videocast - All Events - May 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Automation is enabling big changes in care delivery and access
Dr. Anobel Odisho, associate professor of Urology at the University of California, San Francisco, who will be speaking at HIMSS23, says the true value of automation lies in its ability to free up clinical resources to focus on complex cases. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - April 4, 2023 Category: Information Technology Source Type: video
What learning home dialysis can offer patients
With the proper training and technology, patients with end-stage kidney disease can perform dialysis themselves, says Dr. Shelly Nash, global chief medical information officer at Fresenius Medical Care, who will lead a panel on the topic at HIMSS23. (Source: Healthcare ITNews Videos)
Source: Healthcare ITNews Videos - March 29, 2023 Category: Information Technology Source Type: video
