Pathogenic Tau Drives Cellular Senescence in the Aging Brain
Evidence suggests a multidirectional relationship between cellular senescence, chronic inflammation, and toxic tau aggregation in the aging brain. Inflammation is well known to be associated with the onset and progression of neurodegenerative conditions, and lingering senescent cells present throughout the aging body provide a significant contribution to chronic, unresolved inflammatory signaling. Clearing senescent cells in animal models of neurogeneration has been shown to reduce both inflammation and tau aggregation. Here, researchers show that the presence of pathogenic forms of tau protein can provoke cellular senesce...
Source: Fight Aging! - June 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
poem
Write What You KnowAnytime you ' re stuck or sounding derivative that ’s what they always say. Write what you know. For the longest time I ignored it. Deluded by the arrogance of the overlooked. For fruitless years I wrote about rivers even though I’m clueless. Landlocked and sea sick. I hate to fish. All my rivers just wind and shimmer, wind and shimmer. They bec ome chlorinated lazy rivers lily padded with sunburnt bodies wafting along in blow up rafts. Meanwhile I ' m just using them to skip a stone to the other side. Do you know how long it takes to really know if you know anything? I know a little bit, I ' l...
Source: Buckeye Surgeon - June 6, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
An Example of In Silico Drug Screening for Senolytic Compounds
The average small molecule drug development program starts with a mechanism, an intended outcome such as inhibition, and then screening of as many molecules as possible from the libraries. Sometimes it is possible to make educated guesses as to what types of molecule are more likely to be useful, but often screening must be very broad and with little direction. In principle, low cost computation makes it possible to dramatically reduce the cost of discovery of useful molecules given a specific target mechanism. This shift from physical to in silico screening has been underway for a while, for example at Insilico Medicine, ...
Source: Fight Aging! - June 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 5th 2023
In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation.
Betting Against Progress Turns Out Poorly, But Can Work in the Short Term in a Slow Field
https://www.fightaging.org/archives/2023/06/betting-against-progress-turns-out-poorly-but-can-work-in-the-short-term-in-a-slow-field/
Setting oneself up as a spokesperson for "we will not achieve this goal", as the fellow noted here is choosing to do, is a bet against technological progress. A glance at any few decade period in the past two hundred yea...
Source: Fight Aging! - June 4, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Unconventional health care, flawed studies, and biases: Navigating the complexities for optimal well-being
When I speak with my less “crunchy” peers, I encounter a considerable amount of resistance to ideas that have initially gained traction in naturopathic or integrative spaces: food as medicine, making “non-toxic” swaps, meditation, or reiki, to name a few. As humans, we certainly love a good us vs. them mentality, tribalism and all. But
Read more…
Unconventional health care, flawed studies, and biases: Navigating the complexities for optimal well-being originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 1, 2023 Category: General Medicine Authors: Kara Wada, MD Tags: Physician Allergies & Immunology Source Type: blogs
Don ’ t Blame Burnout
BY SANJ KATYAL
It is hard to open a medical journal in any specialty without seeing an article on burnout. There are statistics, trends, and of course a myriad of causes detailed in these articles. A few even offer some sensible solutions – flexible scheduling, peer support, delegation of clerical work and an increased focus on personal well-being activities are steps in the right direction.
I have previously written that “the absence of burnout does not equal wellness” just as the absence of disease does not imply health. We deserve more than simply the ability to function, we deserve to flourish. Th...
Source: The Health Care Blog - May 31, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Medical Practice Burnout Medical Wellness Sanj Katyal Source Type: blogs
Mitochondrial Quality Control in Microglia in the Aging Brain
Microglia are innate immune cells of the central nervous system, similar to macrophages elsewhere in the body. These cells become more inflammatory and dysfunctional with age, and this is implicated in the onset and progression of neurodegenerative conditions. Chronic inflammation is disruptive of tissue function, and in the brain is connected with a range of pathological mechanisms. Here, researchers discuss the loss of autophagy and related mitochondrial quality control characteristic of age, and how this might affect microglia. Inflammation and mitochondrial dysfunction are connected, one of the many ways in which age-r...
Source: Fight Aging! - May 30, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How to Stay Positive at Work: 22 Helpful Tips
It’s not always easy to stay positive at work.
Sometimes because it’s Monday and you’re tired and would like another weekend right now.
At other times because it’s Wednesday and you are doing some boring routine work or you are being dragged down by negative attitudes around you.
So in today’s post I’d like to share my top 22 tips that help me to have and maintain a positive attitude while I work (and that often helps me in my private life too when things get tough).
I hope these tips will help you to be a positive person in your workplace and also spread the positive vibes to the people around you to make it a...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - May 26, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Career & Work Happiness Personal Development Success Source Type: blogs
How Can Platforms Deal with Toxic Content? Look to Wall Street
The Supreme Court recently opted to keep in place a law that shields tech platforms from liability for hosting toxic content. Congress can and should regulate the industry. And there ' s already a regulatory framework for doing so that accounts for freedom of speech concerns. (Source: The RAND Blog)
Source: The RAND Blog - May 26, 2023 Category: Health Management Authors: James V. Marrone Source Type: blogs
20-something with huge verapamil overdose and cardiogenic shock
A 20-something presented after a huge verapamil overdose in cardiogenic shock. He had been seen at an outside institution and been given 6 g calcium gluconate, KCl, and a norepinephrine drip.The initial K was 3.0 mEq/L and ionized calcium was 5.5 mg/dL (sorry, Europeans, for the weird units)Here was the initial ED ECG:There is a junctional rhythm with retrograde P-waves (see the dip in the T-wave in lead II across the bottom; you can follow that up to all the other leads and see the retrograde P wave). There is also Left Bundle Branch Block (LBBB). There is huge proportionally excessively discord...
Source: Dr. Smith's ECG Blog - May 26, 2023 Category: Cardiology Authors: Steve Smith Source Type: blogs
Towards SIRT6 Upregulation as a Calorie Restriction Mimetic Strategy
Researchers have in recent years expressed a growing interest in the role of sirtuin 6 (SIRT6) in the mechanisms of calorie restriction and improved function that occurs in response to mild stress. Many forms of stress, such as lowered levels of nutrients, produce benefits via upregulation of cellular maintenance processes such as autophagy.
That said, it is unclear as to whether calorie restriction mimetic therapies will prove to be all that interesting as a class of therapy in humans, as calorie restriction only produces significant gains in life span in short-lived species. While scientists are far from a full ac...
Source: Fight Aging! - May 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Our Teaching Persona in Anatomy & Physiology Class | TAPP 137
In Episode 137, host Kevin Patton explores the significance ofplayfulness, transparency, andauthenticity in theteaching persona. Drawing from personal experiences training animals, Kevin explains howplay is integral to learning, highlighting the importance of incorporating asense of fun andembracing failures in the classroom. He also emphasizes the value of transparency bysharing our own mistakes and weaknesses, asserting thatbeing open about flaws fosters authenticity andbuilds trust with students. By acknowledging vulnerabilities and demonstrating a genuine willingness to learn, educators can create asupportive and engag...
Source: The A and P Professor - May 23, 2023 Category: Physiology Authors: Kevin Patton Source Type: blogs
Loneliness Has A Toxic Effect On Brain Activity — May Explain The Condition (M)
Why lonely people feel different and may find it hard to connect with their peers. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - May 21, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Loneliness subscribers-only Source Type: blogs
Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn
A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect
How to Construct Measures of Biological Age
A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals
Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome
Intestinal Barrier Dysfunction as a Feature of Aging in Many Species
NAFLD as an Age-Related Condition
Towards Sensory Hair Cell Regeneration in the Inner Ear
Raised Leve...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
