The 7 Decade History of ChatGPT
By MIKE MAGEE Over the past year, the general popularization of AI orArtificial Intelligence has captured the world’s imagination. Of course, academicians often emphasize historical context. But entrepreneurs tend to agree with Thomas Jefferson who said, “I like dreams of the future better than the history of the past.” This particular dream however is all about language, its standing and significance in human society. Throughout history, language has been a species accelerant, a secret power that has allowed us to dominate and rise quickly (for better or worse) to the position of “masters of the un...
Source: The Health Care Blog - February 19, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech AI ChatGPT History of AI Mike Magee Source Type: blogs

A young man with persistent palpitations
Written by Pendell MeyersA teenager was playing basketball when he suddenly developed palpitations and lightheadedness. He presented soon afterward at the Emergency Department with ongoing symptoms. Mentation and blood pressure were normal. He had no chest pain or shortness of breath. Heart rates on the monitor fluctuated from 180-250 bpm.Here is his triage ECG:What do you think?The ECG shows an irregularly irregular polymorphic wide complex rhythm, with some R-R intervals as short as approximately 220 msec or even less. But it is not disorganized enough to be polymorphic ventricular tachycardia. The rhythm is therefo...
Source: Dr. Smith's ECG Blog - February 16, 2024 Category: Cardiology Authors: Pendell Source Type: blogs

Supporting innovations in cancer treatment and prevention for our nation ’s most vulnerable
By KAT MCDAVITT and LESLIE KIRK Innsena has made a $100,000 contribution to CancerX, making Innsena the public-private partnership’s first Impact Supporter. Why? There are few conditions in which the disparity in innovations benefiting underserved communities is more apparent than in the treatment and prevention of cancer. Patients without insurance are more likely to present with more advanced cancers, and the cancer death rate for people of color is significantly higher than for white patients. More people die from cancer in rural communities than in urban settings.  In CancerX, we found a community of...
Source: The Health Care Blog - February 13, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy CancerX DiME health equity Jennifer Goldsack Kat McDavitt Leslie Kirk Medicaid Moffitt Cancer Center Oncology Ventures Source Type: blogs

Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people. « Back to Top Greater Individual Wealth Correlates with Longer Life Expectancy https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/ Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Bypassing Causes to Focus on Repairing Damaged Synapses in Alzheimer's Disease
Should we expect an approach focused on repair of synapses in neurodegenerative conditions like Alzheimer's disease, while leaving the causative mechanisms of the condition operating intact, to have a large effect on patient outcomes? Given what is known of the underlying mechanisms of protein aggregation, neuroinflammation, and other problems that ultimately kill neurons, not just damage them, it seems possible that synaptic repair might do well in the early stages of cognitive impairment, but later do little to help as the condition progresses. Regardless, it is interesting to consider to degree to which neural function ...
Source: Fight Aging! - February 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Glial Cell Senescence Impairs α-Synuclein Clearance, Contributing to Parkinson's Disease
In this study, we investigated how aging and glial senescence affect the capacity of α-syn clearance. We found that following the intra-striatal injection of human α-syn (hu-α-syn) preformed fibril, hu-α-syn pathology persisted more in aged mice compared with younger mice and that aged microglia exhibited greater accumulation of hu-α-syn than younger microglia. Moreover, in vitro assay revealed that the clearance of hu-α-syn was primarily dependent on the autophagy-lysosome system rather than on the ubiquitin-proteasome system and that the capacity of hu-α-syn clearance was diminished in senescent glia because of au...
Source: Fight Aging! - February 8, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

This Is The Worst Type of Narcissist – They Are Socially Toxic (M)
"They're thinking really negative, hostile, critical things about other people." (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 5, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Narcissism subscribers-only Source Type: blogs

This Is The Worst Type of Narcissist – They Are Socially Toxic
"They're thinking really negative, hostile, critical things about other people." (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 5, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Narcissism Source Type: blogs

Fight Aging! Newsletter, February 5th 2024
In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan. « Back to Top Senolytic CAR T Cell Therapy Improves Health in Aged Mice https://www.fightaging.org/archives/2024/01/senolytic-car-t-cell-therapy-improves-health-in-aged-mice/ To the degree that senescent cells in a tissue exhibit distinctive surface features, one can deploy technologies such as chimeric antigen receptor T cells to selectively destroy them. T cells will destroy whatever cell binds to the chimeric antigen receptor they are equipped w...
Source: Fight Aging! - February 4, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Toxic Family Ties That Are The Most Challenging Relationships You ’ ll Ever Face (M)
Relationships were labelled 'difficult' when the other person demanded support, but did not reciprocate. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 31, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Relationships subscribers-only Source Type: blogs

Amyloid- β Biochemistry as a Cause of Blood-Brain Barrier Leakage in Alzheimer's Disease
Alzheimer's disease is a complex degenerative failure of a complex system, the brain. This complexity is illustrated by the continuing debate over which of the many identified mechanisms are the primary cause. Is it amyloid-β aggregation, or some aspect of the halo of biochemistry associated with that aggregation, or is it chronic inflammation, or cellular senescence in supporting cells of the brain, or vascular dysfunction and leakage of the blood-brain barrier, or neurofibrillary tangles, or the presence of persistent viruses. All of these mechanisms interact with one another, and the direction of causation between any ...
Source: Fight Aging! - January 30, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

RNA Interference as a Mechanism in Alzheimer's Disease
It presently costs little to assess the transcriptomic state of a cell, the amounts and sequences of various RNA transcripts produced from DNA. Thus a fair amount of research into health, disease, and cell biochemistry is focused on this complex layer of cell behavior. It is comparatively easy to produce a great deal of data and identify differences between cells and cell states, but challenging to connect that to other mechanisms and higher level causes and consequences. The research here illustrates this point, in that the researchers can discuss changes in RNA transcripts observed in Alzheimer's disease, but do not disc...
Source: Fight Aging! - January 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

LEV Foundation on Senolytics as One Part of a Combination Rejuvenation Therapy
The primary focus of the Longevity Escape Velocity (LEV) Foundation is to demonstrate that therapies based on the repair of forms of underlying molecular damage that cause aging can be combined to produce greater rejuvenation. Research of recent years has demonstrated quite comprehensively that the alternative strategy for treating aging, to manipulate metabolism into a state in which aging occurs modestly more slowly, has so far produced therapies that largely cannot be combined. The combination of any two or more metabolic alterations, induced by supplements or other small molecules, that individually modestly slow aging...
Source: Fight Aging! - January 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment. Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs