Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Taking Social Determinants of Health (SDoH) From Data to Analysis and Action
The following is a guest article by Diana Zuskov, MPH, Associate Vice President of Healthcare Strategy at LexisNexis® Risk Solutions.
SDoH Success Stories to Inspire Adoption and Action in Your Organization
Healthcare organizations are spending significant resources – time, money, and human capital – to address social determinants of health (SDoH) and health equity. Effective execution requires going upstream of the programming itself to understand the social determinants of a population.
According to Data Bridge Market Research, the U.S. SDoH market is growing with a compound annual growth rate (CAGR) of 22.9% betw...
Source: EMR and HIPAA - March 24, 2023 Category: Information Technology Authors: Guest Author Tags: Analytics/Big Data C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Interoperability Clinical Data Data Action Data Analysis Diana Zuskov EHR Electronic Health Records Health Gorilla Health Gorilla’s Source Type: blogs
Reviewing Blood-Brain Barrier Dysfunction in the Context of Alzheimer's Disease
The biochemistry of the central nervous system is separated from the biochemistry of the rest of the body by the blood-brain barrier, a specialized lining of cells that wrap blood vessels that pass through the brain. Only some molecules and cells are permitted to pass into and out of the brain. Like all bodily systems, the blood-brain barrier breaks down with age, leading to leakage of unwanted molecules and cells into the brain, where they can provoke inflammation and dysfunction. This is thought to provide a significant contribution to the onset and further progression of age-related neurodegenerative conditions, given t...
Source: Fight Aging! - March 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in thi...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reducing Glycerol and Glyceraldehyde Levels Extends Life in Nematodes
Researchers here note an approach to extending life by 50% in nematode worms that functions by lowering levels of glycerol and glyceraldehyde in tissues. Lower animals such as nematodes have a far greater plasticity of life span in response to interventions than is the case for mammals. Thus this research is worth taking note of, a suggestion that this area of metabolism is worthy of more attention, but implementing something similar in mammalian species should not be expected to do more than modestly slow aging.
Glycerol and glyceraldehyde are harmful by-products of fat that naturally accumulate over time. Prior...
Source: Fight Aging! - March 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Microglia Packed Full of Lipofuscin are Harmful in the Aging Brain
In this study we found - in aged animals - that these microglia adopt a unique, dysfunctional state, which has a number of problematic impacts. For example, there is an increase in cellular stress and damage, an accumulation of fats and iron, alterations to metabolic processes and an increase in production of molecules that overstimulate the immune response. Increasing evidence now suggests that the accumulation of autofluorescent microglia contributes to diseases of ageing and neurodegeneration. If these sub-populations of microglia are highly inflammatory and damaging to the brain, then targeting them could be a new stra...
Source: Fight Aging! - March 15, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Lysosomal Overloading Hypothesis of Alzheimer's Disease
Novel immunotherapies for Alzheimer's disease have in recent years finally succeeded in clearing toxic extracellular amyloid-β aggregates from the brain in human clinical trials. Nonetheless, this advance has failed to meaningfully improve patient outcomes. This outcome has led to renewed theorizing on the mechanisms of Alzheimer's disease, in search of an explanation as to how amyloid-β can be so clearly associated with the condition, but fail as a target for therapy.
Some researchers focus on chronic inflammation as the primary mechanism of disease progression, seeing amyloid-β aggregation as a side-effect at b...
Source: Fight Aging! - March 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Misfolded Proteins Accumulate with Age in Nematodes and Mice
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Simplest Way To Improve A Toxic Relationship
Partners with an avoidant attachment style do not want to get close. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 9, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Relationships Source Type: blogs
Progress Towards Clinical Trials for Atherosclerosis at Cyclarity
Cyclarity is taking a fast path to the clinic for clearance of 7-ketocholesterol, a toxic altered form of cholesterol that contributes to the dysfunction of macrophage cells that lies at the root of atherosclerosis. To the degree that macrophage cells can be rescued from the local excess of cholesterol and altered cholesterol present in an atherosclerotic plaque, they will work to dismantle that plaque. The question is whether removing only 7-ketocholesterol will produce a bigger effect on established atherosclerotic plaque than the presently established approach of lowering LDL-cholesterol in the bloodstream. This is a lo...
Source: Fight Aging! - March 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Towards Transplantation of Stem Cell Derived Neurons for Parkinson's Disease
The more obvious manifestations of Parkinson's disease stem from the the loss of a small population of dopamine-generating neurons. These cells are more sensitive to the underlying pathology of α-synuclein protein aggregation that drives the condition. Researchers have been working towards cell therapies that deliver new neurons for a long time now. A variety of clinical trials are underway, using a variety of cell sources; here, one of those programs has advanced to the stage of a first treated patient. None of these programs have yet emerged into widespread clinical practice. Is replacing cells the best way forward in t...
Source: Fight Aging! - March 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/20...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Whoops! AI might have invented 40000 new toxic nerve agents … but probably not
TL:DR – Software used to predict which chemicals in a database have potential as new medicines has been flipped as a warning demonstrating that the same system could be used to predict whether they are highly toxic.
Artificial intelligence, AI, machine learning, language models, neural networks, generative models, algorithms trained on big data. A lovely collection of buzzwords that have been littering grant proposals for years and are now emerging into the real world as apps and websites and citizen science projects. For chemists and pharmaceutical scientists, AI has been a tool to experiment with for a long time. ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 4, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Chemistry Source Type: blogs
Considering Proteostasis and Aging
Proteostasis is the normal maintenance of protein levels and protein structure in a cell. This is disrupted with age, the result of failing quality control, epigenetic change, and other issues. Loss of proteostasis is a hallmark of aging, but has the look of a consequence of aging, not a cause to be addressed. It is also highly complex, and thus progress towards practical therapies is probably better served by a focus on causes of aging rather than the fine details of age-related changes in the cell. Fix the causes, see how well those repair efforts improve long-term health, and then worry about the fine details of the bio...
Source: Fight Aging! - March 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
