Red Blood Cell Extracellular Vesicles Assist Macrophages in Atherosclerotic Plaque
In this study, we investigated the uptake of RBCEVs by macrophages. We also monitored the intracellular trafficking of RBCEVs and the fate of haemoglobin, their most abundant protein cargo. We found that RBCEVs were preferentially taken up by macrophages in the liver and spleen. The EVs then released heme into the cytoplasm via the heme transporter HRG1, which promoted the differentiation of the macrophages to a phenotype characterized by upregulated HO-1 expression, and prevented the accumulation of oxidized low-density lipoproteins (oxLDL) in these cells. This natural therapeutic characteristic of RBCEVs suggests their p...
Source: Fight Aging! - August 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

This Is The Most Stressful Personality Trait
The personality trait strongly linked to stress and 11 ways to reduce the toxic emotion. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 21, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Personality Stress Source Type: blogs

This Behavioural Pattern Is Incredibly Toxic To Any Relationship
An important sign that a relationship is in trouble. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 21, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Relationships Source Type: blogs

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Raised Remnant Cholesterol Level Correlates with Frailty
Remnant cholesterol refers to circulating cholesterol in the bloodstream that is not attached to LDL transport particles coming from the liver or HDL transport particles going to the liver. The remnant is attached to some mix of VLDL and IDL particles that serve much the same purpose as LDL particles, or incorporated into much larger chylomicron transporters that carry dietary lipids from the intestines throughout the body. Researchers have noted that remnant cholesterol appears to contribute to cardiovascular risk, speeding the progression of atherosclerosis and increasing the risk of stroke and heart attack. It is...
Source: Fight Aging! - August 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Vertical Integration Doesn ’t Work in Healthcare:  Time to Move On
Conclusion Healthcare providers of all stripes must leave the industrial world behind. The value chains in health services are not physical, but rather comprised of human relationships, sustained by trust. Virtual care, the advent of AI in healthcare and consumer demand will require a flexible, 24/7 and care anywhere business model. Those who build the best modern clinical mousetrap will end up with a committed clinical staff and loyal patients. Healthcare isn’t about the building, or the brand, or scale. Surviving and thriving in the future will require engaged clinicians who foster trust on the part o...
Source: The Health Care Blog - August 14, 2023 Category: Consumer Health News Authors: matthew holt Tags: The Business of Health Care Hospitals Jeff Goldsmith Physicians Vertical integration Source Type: blogs

Fight Aging! Newsletter, August 14th 2023
This study demonstrates just how vital the thymus is to maintaining adult health." « Back to Top Does Amyloid-β Aggregation Cause Broad Disruption of Proteostasis? https://www.fightaging.org/archives/2023/08/does-amyloid-%ce%b2-aggregation-cause-broad-disruption-of-proteostasis/ Researchers here speculate on the ability of insoluble amyloid-β aggregates to be broadly disruptive of the solubility of many other proteins, and thus disruptive to cell and tissue function. Is this important in aging? The evidence here shows the existence of the mechanism in a lower species, but that doesn't ...
Source: Fight Aging! - August 13, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

“ YES AND ” : a vital, versatile, and visionary leadership tool
Patient safety, patient experience, workforce health, and cost-effectiveness are critical outcomes that share important common roots. They are all impacted by our ability to communicate effectively and respectfully. This can be challenging, in part, because communication involves underlying emotional intelligence, which is hard to develop and practice, especially in high-stakes, high-stress work environments or toxic Read more… “YES AND”: a vital, versatile, and visionary leadership tool originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 11, 2023 Category: General Medicine Authors: Tags: Conditions Primary Care Source Type: blogs

Reshaping opioid policies: a patient advocate ’ s call [PODCAST]
Subscribe to The Podcast by KevinMD. Catch up on old episodes! Join patient advocate Richard A. Lawhern as he challenges prevailing myths surrounding the opioid crisis. With insights from medical literature, he questions the link between opioid prescribing and toxicity, highlighting the need for evidence-based public health policies. Learn about the human toll of opioid Read more… Reshaping opioid policies: a patient advocate’s call [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 9, 2023 Category: General Medicine Authors: Tags: Podcast Pain Management Source Type: blogs

Light-Activated Hydrogel Thickens, Reshapes Thinning Cornea
Researchers at the University of Ottawa have developed a light-activated hydrogel treatment for corneal disease. Many of the people who suffer from corneal disease, which can include corneal thinning, are not suitable for a corneal transplant, and obtaining transplants is a challenge for those who are. This technology is intended to assist with thickening and reshaping the cornea, and it may pave the way for an alternative to transplants in the future. The biomaterial is made using glycosaminoglycans, which are polymers that occur naturally in the body, and short peptides. Following injection into a surgically create...
Source: Medgadget - August 9, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Ophthalmology uOttawa Source Type: blogs

Selective Disruption of Replication in Cancerous Cells by Targeting PCNA
The future of cancer therapy will involve the targeting of mechanisms found broadly in many or all different types of cancer, that cancer cells cannot dispense with as they evolve rapidly within a tumor, and which have little to no effect on non-cancerous cells. Targeting telomerase to prevent the lengthening of telomeres can check the first two of those boxes, leaving the question of how best to effectively restrict the treatment to tumor cells. Targeting alternative lengthening of telomeres can check the second and third boxes, but the mechanism only operates in a minority of cancers. The research community is engaged in...
Source: Fight Aging! - August 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seem...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Mitochondrial Transplantation as a Treatment for Kidney Damage
It is interesting see an increased focus on assessing the ability of mitochondrial transplantation to be useful in a variety of circumstances, not just as a treatment to reduce the mitochondrial dysfunction that occurs with aging. The limiting factor in bringing mitochondrial transplantation to the clinic is chiefly the speed at which the research and development communities can achieve the logistical advances needed to reliably produce enough mitochondria to deliver to an entire organ (at first), and the whole body (later). It is likely the case that mitochondria will have to be patient-matched by haplotype of mitochondri...
Source: Fight Aging! - August 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

How to handle a toxic person
Dealing with a toxic person close to you is traumatic, draining, and upsetting. My older sister is a toxic person, and I endured her behavior for over 40 years. I recommend making a clean break from a toxic person around the holidays and birthdays when their behavior is at its worst. You might blame yourself Read more… How to handle a toxic person originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 3, 2023 Category: General Medicine Authors: Tags: Conditions Psychiatry Source Type: blogs

NRF2 in the Oxidative Stress of Alzheimer's Disease
There are many ways of looking at the pathology of Alzheimer's disease, as it is very complex, layered condition. One of these viewpoints is to note that levels of oxidative stress increase in the Alzheimer's brain, stressing and killing cells. Researchers here report on their investigation of changes in the NRF2-centered regulation of cellular antioxidant systems that take pace in the Alzheimer's brain. A decline in antoxidants accelerates the progression of cell death and dysfunction, but this can be slowed or prevented by suitably targeted intervention aimed at maintaining NRF2 activity. Whether or not this is too far d...
Source: Fight Aging! - August 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs