How to handle a toxic person
Dealing with a toxic person close to you is traumatic, draining, and upsetting. My older sister is a toxic person, and I endured her behavior for over 40 years. I recommend making a clean break from a toxic person around the holidays and birthdays when their behavior is at its worst. You might blame yourself
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How to handle a toxic person originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - August 3, 2023 Category: General Medicine Authors: Bethany Silverman Tags: Conditions Psychiatry Source Type: blogs
NRF2 in the Oxidative Stress of Alzheimer's Disease
There are many ways of looking at the pathology of Alzheimer's disease, as it is very complex, layered condition. One of these viewpoints is to note that levels of oxidative stress increase in the Alzheimer's brain, stressing and killing cells. Researchers here report on their investigation of changes in the NRF2-centered regulation of cellular antioxidant systems that take pace in the Alzheimer's brain. A decline in antoxidants accelerates the progression of cell death and dysfunction, but this can be slowed or prevented by suitably targeted intervention aimed at maintaining NRF2 activity. Whether or not this is too far d...
Source: Fight Aging! - August 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Repair Biotechnologies View of Cholesterol Pathology at the 2023 Foresight Longevity Workshop
I attended the Foresight Institute's 2023 Longevity Frontiers Workshop earlier in the year. This event series provides a chance to make connections with some of the longevity industry figures and academic researchers in the field of aging that are associated with the Bay Area venture and futurist communities. The format this year was rapid-fire seven minute presentations and longer discussions; the presentations are shared online. I presented an informal, abbreviated version of the Repair Biotechnologies viewpoint on the role of cholesterol in aging and disease, trying to cover at least the important points in the time all...
Source: Fight Aging! - July 27, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Is More Physician-Owned Hospitals the Solution to our Health Cost problem?
BY JEFF GOLDSMITH
Robert Frost once said, “Home is where, when you have to go there, they have to take you in.”
Increasingly, in our struggling society, that place is your local full service community hospital. During COVID, if it wasn’t your local hospital standing up testing sites, pumping out vaccinations and working double overtime helping patients breathe, we would have lost several hundred thousand more of our fellow Americans.
But it wasn’t just COVID where hospitals leaped into the breach. As primary care physicians’ practices collapsed from documentation overburde...
Source: The Health Care Blog - July 26, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: The Business of Health Care Affordable Care Act COVID Jeff Goldsmith Physician-Owned hospitals Source Type: blogs
The Ketone Body β-hydroxybutyrate is Involved in Clearance of Amyloid-β
Researchers here note an interesting role for one of the common ketone bodies found in mammalian biochemistry, in that it provokes clearance of amyloid-β via its interaction with that molecule. An increase in misfolded amyloid-β is involved in the early stages of Alzheimer's disease, and seems likely to cause some fraction of the pathology of that condition. If comparatively simple approaches could keep amyloid-β levels low in later life, then the incidence of Alzheimer's disease might be reduced. That said, while the mechanism described here is interesting, it doesn't mean that the effect size, relative to other mechan...
Source: Fight Aging! - July 26, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Thinking on Your Feet Well: Building Adaptive Expertise in Learners Using Simulation
On this episode of the Academic Medicine Podcast, Sam Clarke, MD, MAS, and Jon Ilgen, MD, PhD, join host Toni Gallo to discuss the importance of teaching adaptive expertise to prepare learners for the types of complex cases they will encounter in clinical practice. This conversation also covers what adaptive expertise is, how simulation can be used to foster this skill in learners, and the complementary relationship between performance-oriented cases and adaptive cases in health professions education.
This episode is now available through Apple Podcasts, Spotify, and anywhere else podcasts are available.
...
Source: Academic Medicine Blog - July 24, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast adaptive expertise medical education medical students residents simulation Source Type: blogs
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
5 Warning Signs Of A Toxic Personality
How to spot people with a toxic personality. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - July 20, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Personality Source Type: blogs
Inhibition of Glycolysis as a Treatment for Neurodegeneration
Researchers here discuss a program of drug discovery that led to inhibitors of glycolysis as a potential approach to treatment for neurodegenerative conditions. The researchers note that elevated glycolysis is a characteristic of Alzheimer's disease, for example. There are always many, many mechanisms and altered aspects of cell metabolism one can investigate in aging and age-related disease. The question to ask when looking at any one specific mechanism in isolation is how much of the pathology of the condition lies downstream of this mechanism. It is all to easy to find oneself targeting a side-effect, or a minor mechani...
Source: Fight Aging! - July 18, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Alpha-Blockers For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
To summarize, the treatment of hypertension is a critical aspect of healthcare due to its significant impact on cardiovascular health.
While natural supplements and lifestyle modifications are important for overall well-being, the use of chemical drugs in managing hypertension remains necessary.
Chemical drugs for hypertension have undergone extensive research and have been proven effective in lowering blood pressure levels.
Alpha-blockers offer a targeted approach to address the specific mechanisms involved in hypertension, allowing for precise blood pressure control.
They work by inhibiting the ...
Source: The EMT Spot - July 17, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.
Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease
https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/
With the caveat that mouse models of Alzheimer'...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Opinion Piece from Pharmacists United for Truth & Transparency ( " PUTT " )
Pharmacists United for Truth& Transparency ( " PUTT " ) is a non-profit advocacy organization founded by independent pharmacists and pharmacy owners devoted to exposing what they describe as anti-competitive tactics deployed by the largest Pharmacy Benefit Managers (PBMs - aka Pharmacy Benefit Companies or PBCs as the trade organization known as the Pharmaceutical Care Management Association or PCMA has tried to rebrand its industry since the acronym PBM has become toxic) recently published an opinion piece with an interesting title: " The Deadliest Addiction in the U.S. Isn ' t What You Think It Is " (read it athttps:...
Source: Scott's Web Log - July 12, 2023 Category: Endocrinology Tags: 2023 drug prices PBM Pharmacists United for Truth & Transparency PUTT Source Type: blogs
Recombinant Klotho Treatment Improves Cognitive Function in Old Rhesus Macaques
Klotho is one of the few genuinely longevity-associated genes, in that greater than normal expression increases life span in mice, while lower than normal expression shortens life span in mice. In humans, greater levels of circulating soluble klotho correlate with greater longevity. Klotho is thought to operate in the kidneys, in some way that is protective against the mechanisms of age-related decline, but there is a great deal of evidence for greater circulating klotho to improve cognitive function. At the same time, it seems unclear as to whether klotho is actually doing anything in the brain; it may be that the benefit...
Source: Fight Aging! - July 12, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Angiotensin II Receptor Blockers (ARBs) For High Blood Pressure: Types, Side Effects, Drug Interactions
Conclusion
Cardiovascular disease (CVD) has become a leading cause of death globally, necessitating the adoption of preventive measures, early detection, and effective management strategies.
Hypertension, a significant risk factor for CVD, requires active management to mitigate associated risks.
Angiotensin II Receptor Blockers (ARBs) have emerged as a favored choice among healthcare professionals due to their effectiveness and unique benefits.
ARBs offer several advantages compared to other blood pressure medications. They effectively control blood pressure, protect vital organs such as the heart and kidneys, ...
Source: The EMT Spot - July 11, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
