Efficacy and safety of Tripterygium wilfordii multiglucoside for idiopathic membranous nephropathy: a systematic review with bayesian meta-analysis
Conclusion: The addition of TWM may be beneficial to patients with IMN. It may enhance the efficacy of previously established treatment protocols without leading to additional safety risks. In particular, GC + CNI + TWM, GC + TWM, and CNI + TWM with better efficacy and higher safety can be preferred in clinical decision-making as the therapy plans for IMN. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - August 2, 2023 Category: Drugs & Pharmacology Source Type: research
Tripterine inhibits proliferation and promotes apoptosis of keloid fibroblasts by targeting ROS/JNK signaling
J Burn Care Res. 2023 Jul 12:irad106. doi: 10.1093/jbcr/irad106. Online ahead of print.ABSTRACTKeloids are benign skin tumors characterized by excessive fibroblast proliferation and collagen deposition. The current treatment of keloids with hormone drug injection, surgical excision, radiotherapy, physical compression, laser therapy, cryotherapy often have unsatisfactory outcomes. The phytochemical compounds have shown great potential in treating keloids. Tripterine, a natural triterpene derived from the traditional Chinese medicine Thunder God Vine (Tripterygium wilfordii), was previously reported to exhibit an anti-scarri...
Source: Cell Research - July 12, 2023 Category: Cytology Authors: Fang Huang Enjing Zhang Yan Lei Qiong Yan Chengbin Xue Source Type: research
The roles of TPL in hematological malignancies
Hematology. 2023 Dec;28(1):2231765. doi: 10.1080/16078454.2023.2231765.ABSTRACTTriptolide (TPL) is a diterpenoid isolated from the traditional Chinese medicine Tripterygium wilfordii. It has powerful antitumor, immunosuppressive and anti-inflammatory properties. Recent studies have shown that TPL can induce apoptosis of hematological tumor cells, inhibit their proliferation and survival, promote autophagy and ferroptosis, and enhance the efficacy of traditional chemotherapy and targeted therapies. Various molecules and signaling pathways, such as NF-κB, BCR-ABL, and Caspase, are involved in inducing apoptosis of leukemia ...
Source: Hematology - July 5, 2023 Category: Hematology Authors: Tingyun Xu Yiwei Zhu Shuaishuai Ge Song-Bai Liu Source Type: research
Secondary Metabolite Analysis of Phomopsis sp. LGT-5 Based on the Dual Guidance of Whole-genome Sequencing and HPLC-Q-ToF-MS/MS
Chem Biodivers. 2023 Jun 15:e202300275. doi: 10.1002/cbdv.202300275. Online ahead of print.ABSTRACTMicroorganisms produce a wealth of structurally diverse specialized metabolites with a remarkable range of biological activities. The Phomopsis sp. LGT-5 was obtained through tissue block and repeatedly crossed methods from Tripterygium wilfordii Hook. F. The antibacterial experiments of LGT-5 showed that it has high inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa, and moderate inhibitory activity against Candida albicans. To research the generation of the antibacterial phenomenon of LGT-5 and pro...
Source: Chemistry and Biodiversity - June 15, 2023 Category: Biochemistry Authors: Xiuli Wu Jia-Jia Zhu Na Xi Cheng Liu Ping-Yang Ma Xin-Yuan Wu Li Zhou Zhen-Yu An Zhi-Bo Jiang Jian-Huan Wang Source Type: research
Secondary Metabolite Analysis of Phomopsis sp. LGT-5 Based on the Dual Guidance of Whole-genome Sequencing and HPLC-Q-ToF-MS/MS
Chem Biodivers. 2023 Jun 15:e202300275. doi: 10.1002/cbdv.202300275. Online ahead of print.ABSTRACTMicroorganisms produce a wealth of structurally diverse specialized metabolites with a remarkable range of biological activities. The Phomopsis sp. LGT-5 was obtained through tissue block and repeatedly crossed methods from Tripterygium wilfordii Hook. F. The antibacterial experiments of LGT-5 showed that it has high inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa, and moderate inhibitory activity against Candida albicans. To research the generation of the antibacterial phenomenon of LGT-5 and pro...
Source: Chemistry and Biodiversity - June 15, 2023 Category: Biochemistry Authors: Xiuli Wu Jia-Jia Zhu Na Xi Cheng Liu Ping-Yang Ma Xin-Yuan Wu Li Zhou Zhen-Yu An Zhi-Bo Jiang Jian-Huan Wang Source Type: research
Identification of potent target and its mechanism of action of Tripterygium wilfordii Hook F in the treatment of lupus nephritis
ConclusionThe mRNA expression profile of renal tissue from LN patients revealed a large number of DEGs. TWHF has been shown to interact with the DEGs (including HMOX1, ALB and CASP1) through hydrogen bonding to treat LN. (Source: International Journal of Rheumatic Diseases)
Source: International Journal of Rheumatic Diseases - June 15, 2023 Category: Rheumatology Authors: Bin Cai,
Hongjuan Lu,
Qianyi Ye,
Qingqing Xiao,
Xin Wu,
Huji Xu Tags: ORIGINAL ARTICLE Source Type: research
Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
Irritable bowel syndrome (IBS) is a chronic disorder of the gut-brain axis with significant morbidity. Triptolide, an active compound extracted from Tripterygium wilfordii Hook F (TwHF), has been widely used a... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - June 12, 2023 Category: Gastroenterology Authors: Ning Zhu, Liuyan Zhu, Xueliang Zhang, Chengbin Huang, Wenjun Xiang and Bingwu Huang Tags: Research Source Type: research
Molecules, Vol. 28, Pages 4708: Triptonodiol, a Diterpenoid Extracted from Tripterygium wilfordii, Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer
This study suggests that Triptonodiol reduces the aggressive phenotype of NSCLC by inhibiting cytoskeletal remodeling and is a promising anti-tumor compound. (Source: Molecules)
Source: Molecules - June 12, 2023 Category: Chemistry Authors: Xiaochen Ni Xiaomin Jiang Shilong Yu Feng Wu Jun Zhou Defang Mao Haibo Wang Yanqing Liu Feng Jin Tags: Article Source Type: research
Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
Biomed Pharmacother. 2023 Jun 5;164:114981. doi: 10.1016/j.biopha.2023.114981. Online ahead of print.ABSTRACTLipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2023 Category: Drugs & Pharmacology Authors: Jia Gu Ya-Ning Shi Neng Zhu Hong-Fang Li Chan-Juan Zhang Li Qin Source Type: research
Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
Biomed Pharmacother. 2023 Jun 5;164:114981. doi: 10.1016/j.biopha.2023.114981. Online ahead of print.ABSTRACTLipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2023 Category: Drugs & Pharmacology Authors: Jia Gu Ya-Ning Shi Neng Zhu Hong-Fang Li Chan-Juan Zhang Li Qin Source Type: research
Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
Biomed Pharmacother. 2023 Jun 5;164:114981. doi: 10.1016/j.biopha.2023.114981. Online ahead of print.ABSTRACTLipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating l...
Source: Atherosclerosis - June 7, 2023 Category: Cardiology Authors: Jia Gu Ya-Ning Shi Neng Zhu Hong-Fang Li Chan-Juan Zhang Li Qin Source Type: research
Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
Biomed Pharmacother. 2023 Jun 5;164:114981. doi: 10.1016/j.biopha.2023.114981. Online ahead of print.ABSTRACTLipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating l...
Source: Atherosclerosis - June 7, 2023 Category: Cardiology Authors: Jia Gu Ya-Ning Shi Neng Zhu Hong-Fang Li Chan-Juan Zhang Li Qin Source Type: research
Molecular mechanism and research progress on pharmacology of ferulic acid in liver diseases
Ferulic acid (FA) is a natural polyphenol, a derivative of cinnamic acid, widely found in Angelica, Chuanxiong and other fruits, vegetables and traditional Chinese medicine. FA contains methoxy, 4-hydroxy and carboxylic acid functional groups that bind covalently to neighbouring adjacent unsaturated Cationic C and play a key role in many diseases related to oxidative stress. Numerous studies have shown that ferulic acid protects liver cells and inhibits liver injury, liver fibrosis, hepatotoxicity and hepatocyte apoptosis caused by various factors. FA has protective effects on liver injury induced by acetaminophen, methotr...
Source: Frontiers in Pharmacology - May 31, 2023 Category: Drugs & Pharmacology Source Type: research
Autophagy in the pharmacological activities of celastrol (Review)
Exp Ther Med. 2023 Apr 20;25(6):268. doi: 10.3892/etm.2023.11967. eCollection 2023 Jun.ABSTRACTCelastrol, a natural compound extracted from the traditional Chinese medicinal herb Tripterygium wilfordii Hook F, possesses broad-spectrum pharmacological properties. Autophagy is an evolutionarily conserved catabolic process through which cytoplasmic cargo is delivered to the lysosomes for degradation. Autophagy dysregulation contributes to multiple pathological processes. Therefore, targeting autophagic activity is a promising therapy for various diseases, as well as a drug-development strategy. According to previous studies, ...
Source: Experimental and Therapeutic Medicine - May 19, 2023 Category: General Medicine Authors: Caixia Zhang Weiyan Wang Chenhui Du Huifang Li Kun Zhou Zhihua Luan Yinxia Chang Shan Liu Yanming Wei Source Type: research
