Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells
CONCLUSION: Cel gel reduces the secretion of IL-23 from LCs and inhibits the interaction between LCs and γδT cells to alleviate psoriasis. It also shows an effect similar to that of glucocorticoids, which can prevent psoriasis recurrence. These findings provide a new direction for the clinical treatment of psoriasis and contribute to the development of novel drugs.PMID:35051865 | DOI:10.1016/j.biopha.2022.112644 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 20, 2022 Category: Drugs & Pharmacology Authors: Liu Liu Xi Chen Yi Lu Xiao-Ying Sun Kan Ze Ya-Qiong Zhou Wei Li Xin Li Hong-Jin Li Bin Li Source Type: research

Celastrol gel ameliorates imiquimod-induced psoriasis-like dermatitis in mice by targeting Langerhans cells
CONCLUSION: Cel gel reduces the secretion of IL-23 from LCs and inhibits the interaction between LCs and γδT cells to alleviate psoriasis. It also shows an effect similar to that of glucocorticoids, which can prevent psoriasis recurrence. These findings provide a new direction for the clinical treatment of psoriasis and contribute to the development of novel drugs.PMID:35051865 | DOI:10.1016/j.biopha.2022.112644 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 20, 2022 Category: Drugs & Pharmacology Authors: Liu Liu Xi Chen Yi Lu Xiao-Ying Sun Kan Ze Ya-Qiong Zhou Wei Li Xin Li Hong-Jin Li Bin Li Source Type: research

Safety Evaluation of Natural Drugs in Chronic Skeletal Disorders: A Literature Review of Clinical Trials in the Past 20 years
Chronic skeletal disorders (CSDs), including degenerative diseases such as osteoporosis (OP) and autoimmune disorders, have become a leading cause of disability in an ageing society, with natural drugs being indispensable therapeutic options. The clinical safety evaluation (CSE) of natural drugs in CSDs has been given priority and has been intensively studied. To provide fundamental evidence for the clinical application of natural drugs in the elderly population, clinical studies of natural drugs in CSDs included in this review were selected from CNKI, Web of Science, PubMed, Science Direct and Google Scholar since 2001. S...
Source: Frontiers in Pharmacology - January 13, 2022 Category: Drugs & Pharmacology Source Type: research

Nine New Dihydro- β-agarofuran Sesquiterpene Polyesters from the Leaves of Tripterygium wilfordii
New J. Chem., 2022, Accepted Manuscript DOI: 10.1039/D1NJ03800A, PaperLe Zhou, Ming Bai, Qingjun He, Zilin Hou, Liwei Lu, Jie Wang, Xiaoxiao Huang, Bin Lin, Shaojiang Song Nine previously undescribed dihydro- β-agarofuran type sesquiterpene polyesters, tripteresters A−I (1-9), along with three known analogues (10-12), were isolated from the leaves of Tripterygium wilfordii. Their chemical structures were elucidated using... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - January 11, 2022 Category: Chemistry Authors: Le Zhou Source Type: research

Based on Network Pharmacology Tools to Investigate the Mechanism of < em > Tripterygium wilfordii < /em > Against IgA Nephropathy
Conclusion: Our research strengthened the mechanisms of TwHF in treating IgAN, inhibition of JUN activation may play a pivotal role in TwHF in alleviating IgAN renal injury.PMID:34977095 | PMC:PMC8715946 | DOI:10.3389/fmed.2021.794962 (Source: Atherosclerosis)
Source: Atherosclerosis - January 3, 2022 Category: Cardiology Authors: Ming Xia Di Liu Haiyang Liu Juanyong Zhao Chengyuan Tang Guochun Chen Yu Liu Hong Liu Source Type: research

Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1
In conclusion, co- and pre-incubation of the tested TWHF components inhibited OATP1B1 activity in different manners. Although co-incubation of WFG and WFR did not seem to directly compete with the substrates, pre-incubation of these alkaloids may alter the substrate-transporter interaction.PMID:34958783 | DOI:10.1016/j.taap.2021.115848 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 27, 2021 Category: Toxicology Authors: Jieru Chen Yuanping Xue Xiaoyu Shuai Chunxu Ni Zihui Fang Ling Ye Mei Hong Source Type: research

Effect of major components of Tripterygium wilfordii Hook. f on the uptake function of organic anion transporting polypeptide 1B1
In conclusion, co- and pre-incubation of the tested TWHF components inhibited OATP1B1 activity in different manners. Although co-incubation of WFG and WFR did not seem to directly compete with the substrates, pre-incubation of these alkaloids may alter the substrate-transporter interaction.PMID:34958783 | DOI:10.1016/j.taap.2021.115848 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - December 27, 2021 Category: Toxicology Authors: Jieru Chen Yuanping Xue Xiaoyu Shuai Chunxu Ni Zihui Fang Ling Ye Mei Hong Source Type: research

Calcineurin inhibitor therapy in combination with Tripterygium wilfordii polyglycoside tablets for idiopathic membranous nephropathy: A retrospective clinical observation
To compare the efficacy and safety of calcineurin inhibitor (CNI) and Tripterygium wilfordii polyglycoside tablets (TWPs) in treating idiopathic membranous nephropathy (IMN) with CNI and glucocorticoids (GCs). Data of patients with IMN who were treated with CNI+TWPs (TWP group) or CNI+GCs (GC group) and followed up for more than 12 months at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from 2017 to 2020 were retrospectively analyzed. The 24-h urine protein (24hUP), serum albumin (ALB), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), serum creatinine, alanine aminotrans...
Source: Medicine - December 23, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Triptonide effectively inhibits triple-negative breast cancer metastasis through concurrent degradation of Twist1 and Notch1 oncoproteins
CONCLUSIONS: Triptonide effectively suppressed TNBC cell tumorigenesis, vasculogenic mimicry, and strongly inhibited the metastasis of TNBC via degradation of Twist1 and Notch1 oncoproteins, downregulation of metastatic and angiogenic gene expression, and reduction of NF-κB signaling pathway. Our findings provide a new strategy for treating highly lethal TNBC and offer a potential new drug candidate for combatting this aggressive disease.PMID:34922602 | DOI:10.1186/s13058-021-01488-7 (Source: Cell Research)
Source: Cell Research - December 19, 2021 Category: Cytology Authors: Mengli Zhang Mei Meng Yuxi Liu Jindan Qi Zhe Zhao Yingnan Qiao Yanxing Hu Wei Lu Zhou Zhou Peng Xu Quansheng Zhou Source Type: research

New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 4, 2021 Category: Drugs & Pharmacology Source Type: research

Effects of RNAi-mediated plasma membrane calcium transporting ATPase and inositol 1,4,5-trisphosphate receptor gene silencing on the susceptibility of Mythimna separata to wilforine
Ecotoxicol Environ Saf. 2021 Oct 18;227:112909. doi: 10.1016/j.ecoenv.2021.112909. Online ahead of print.ABSTRACTWilforine, a compound of sesquiterpene alkaloids isolated from Tripterygium wilfordii, exhibits excellent insecticidal activity against Mythimna separata. In order to clarify the action mechanism of wilforine, the plasma membrane calcium transporting ATPase (PMCA) and inositol 1,4,5-trisphosphate receptor (IP3R) from M. separata were studied. Results showed that the open reading frame of MsIP3R and MsPMCA were 8118 bp and 3438 bp in length, as well as encoded 2706 and 1146 amino acids, respectively. Multiple seq...
Source: Ecotoxicology and Environmental Safety - October 21, 2021 Category: Environmental Health Authors: Xiao-Peng Lu Jia-Huan Liu Xiang-Yun Fu Feng-Jin Wang Hua Wu Hua Weng Zhi-Qing Ma Source Type: research

The Efficacy of Triptolide in Preventing Diabetic Kidney Diseases: A Systematic Review and Meta-Analysis
Ethnopharmacological Relevance: Triptolide (TP), the primary biologically active ingredient of Tripterygium wilfordii Hook F (TWHF), possesses the potential to solve the shortcomings of TWHF in treating diabetic kidney disease (DKD) in the clinic.Aim of the Study: We conducted a meta-analysis to evaluate the efficacy of TP in treating DKD and offer solid evidence for further clinical applications of TP.Materials and Methods: Eight databases (CNKI, VIP, CBM, WanFang, PubMed, Web of Science, EMBASE, and Cochrane library) were electronically searched for eligible studies until October 17, 2020. We selected animal experimental...
Source: Frontiers in Pharmacology - October 1, 2021 Category: Drugs & Pharmacology Source Type: research

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux
CONCLUSIONS: Taken together, our data demonstrated that T-96 is a novel modulator of ER stress and autophagy, and has potential therapeutic applications against CaP in the clinic.PMID:34488902 | DOI:10.1186/s40659-021-00350-6 (Source: Cell Research)
Source: Cell Research - September 7, 2021 Category: Cytology Authors: Dong-Lin Yang Ya-Jun Zhang Liu-Jun He Chun-Sheng Hu Li-Xia Gao Jiu-Hong Huang Yan Tang Jie Luo Dian-Yong Tang Zhong-Zhu Chen Source Type: research

Demethylzeylasteral (T-96) initiates extrinsic apoptosis against prostate cancer cells by inducing ROS-mediated ER stress and suppressing autophagic flux
Demethylzeylasteral (T-96) is a pharmacologically active triterpenoid monomer extracted from Tripterygium wilfordii Hook F (TWHF) that has been reported to exhibit anti-neoplastic effects against several types of... (Source: Biological Research)
Source: Biological Research - September 6, 2021 Category: Biomedical Science Authors: Dong-lin Yang, Ya-jun Zhang, Liu-jun He, Chun-sheng Hu, Li-xia Gao, Jiu-hong Huang, Yan Tang, Jie Luo, Dian-yong Tang and Zhong-zhu Chen Tags: Research article Source Type: research

Novel Therapies for Kidney Disease in People with Diabetes
CONCLUSION: Trials have yielded promising results in the search for new therapies to manage DKD. Sodium-glucose cotransporter-2 inhibitors and incretin-related therapies have demonstrated benefit and were associated with improved cardiovascular outcomes. Mineralocorticoid-receptor antagonists are another class of agents with increasing evidence of benefits.PMID:34460928 | DOI:10.1210/clinem/dgab639 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 30, 2021 Category: Endocrinology Authors: Nayana Khurana Steven James Melinda T Coughlan Richard J MacIsaac Elif I Ekinci Source Type: research

Novel Therapies for Kidney Disease in People with Diabetes
CONCLUSION: Trials have yielded promising results in the search for new therapies to manage DKD. Sodium-glucose cotransporter-2 inhibitors and incretin-related therapies have demonstrated benefit and were associated with improved cardiovascular outcomes. Mineralocorticoid-receptor antagonists are another class of agents with increasing evidence of benefits.PMID:34460928 | DOI:10.1210/clinem/dgab639 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 30, 2021 Category: Endocrinology Authors: Nayana Khurana Steven James Melinda T Coughlan Richard J MacIsaac Elif I Ekinci Source Type: research

Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity Celastrol Mimic with Better Druggability
Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine (Tripterygium wilfordii Hook.f.), has shown remarkable potency against obesity, inflammation and cancer, but its high toxicity, low natural abundance and tedious chemical synthesis hindered its translation into clinics. In the present work, a triterpenoid library was screened for compounds with both high natural abundance and structural similarity to cela...
Source: Frontiers in Pharmacology - August 30, 2021 Category: Drugs & Pharmacology Source Type: research

Exploring the Pharmacological Mechanisms of < em > Tripterygium wilfordii < /em > Hook F against Cardiovascular Disease Using Network Pharmacology and Molecular Docking
CONCLUSIONS: These findings demonstrate that the main active compound of TwHF, the core targets, and pathways maybe provide new insights into the development of a natural therapy for the prevention and treatment of CVD.PMID:34435046 | PMC:PMC8382521 | DOI:10.1155/2021/5575621 (Source: Biomed Res)
Source: Biomed Res - August 26, 2021 Category: Research Authors: Bingwu Huang Chengbin Huang Liuyan Zhu Lina Xie Yi Wang Ning Zhu Source Type: research

The Immunomodulatory Effect of Triptolide on Mesenchymal Stromal Cells
In this study, we aimed to use TPL to prime umbilical cord-derived MSCs (TPL-primed UC-MSCs) to enter a stronger immunosuppressive status. UC-MSCs were primed with TPL, which was washed out thoroughly, and the TPL-primed UC-MSCs were resuspended in fresh medium. Although TPL inhibited the proliferation of UC-MSCs, 0.01 μM TPL for 24 h was tolerable. The surface markers of TPL-primed UC-MSCs were identical to those of non-primed UC-MSCs. TPL-primed UC-MSCs exhibited stronger anti-proliferative effect for activated CD4+ and CD8+ T cells in the allogeneic mixed lymphocyte reaction assay than the non-primed UC-MSCs. TP...
Source: Frontiers in Immunology - August 16, 2021 Category: Allergy & Immunology Source Type: research

Effect of Tripterygium wilfordii polyglycoside tablets on serum inflammatory factors and T cells in patients with chronic nephritis
Am J Transl Res. 2021 Jul 15;13(7):8385-8390. eCollection 2021.ABSTRACTOBJECTIVE: Investigate the effect of Tripterygium wilfordii polyglycoside tablets on serum inflammatory factors and T cells in patients with chronic nephritis.METHODS: A total of 89 patients with chronic nephritis were randomly divided into a control group (44 cases, treated with irbesartan hydrochlorothiazide combined with dipyridamole) and an observation group (45 cases, treated with Tripterygium wilfordii polyglycoside tablets based on irbesartan hydrochlorothiazide and dipyridamole like the control group). Patients in both groups were treated for tw...
Source: American Journal of Translational Research - August 11, 2021 Category: Research Authors: Qingzhen Li Yong Huang Peipei Liu Hui Yuan Jisheng Zhao Source Type: research

Celastrol Attenuates Learning and Memory Deficits in an Alzheimer's Disease Rat Model
In conclusion, CEL could exert protective effects against learning and memory decline induced by intrahippocampal Aβ 25-35 through anti-inflammation, promote synaptic development, and maintain hippocampal energy metabolism.PMID:34350293 | PMC:PMC8328733 | DOI:10.1155/2021/5574207 (Source: Biomed Res)
Source: Biomed Res - August 5, 2021 Category: Research Authors: Yao Xiao Xifeng Wang Siyi Wang Jun Li Xueyu Xu Min Wang Gang Li Wei Shen Source Type: research

Celastrol Attenuates Learning and Memory Deficits in an Alzheimer's Disease Rat Model
In conclusion, CEL could exert protective effects against learning and memory decline induced by intrahippocampal Aβ 25-35 through anti-inflammation, promote synaptic development, and maintain hippocampal energy metabolism.PMID:34350293 | PMC:PMC8328733 | DOI:10.1155/2021/5574207 (Source: Biomed Res)
Source: Biomed Res - August 5, 2021 Category: Research Authors: Yao Xiao Xifeng Wang Siyi Wang Jun Li Xueyu Xu Min Wang Gang Li Wei Shen Source Type: research

Molecules, Vol. 26, Pages 4700: The Therapeutic Potential of Celastrol in Central Nervous System Disorders: Highlights from In Vitro and In Vivo Approaches
Trabace Celastrol, the most abundant compound derived from the root of Tripterygium wilfordii, largely used in traditional Chinese medicine, has shown preclinical and clinical efficacy for a broad range of disorders, acting via numerous mechanisms, including the induction of the expression of several neuroprotective factors, the inhibition of cellular apoptosis, and the decrease of reactive oxygen species (ROS). Given the crucial implication of these pathways in the pathogenesis of Central Nervous System disorders, both in vitro and in vivo studies have focused their attention on the possible use of this compound in th...
Source: Molecules - August 3, 2021 Category: Chemistry Authors: Stefania Schiavone Maria Grazia Morgese Paolo Tucci Luigia Trabace Tags: Review Source Type: research

Pharmacokinetics and Tissue Distribution of Combined Triptolide and Paeoniflorin Regimen for Percutaneous Administration in Rats Assessed by Liquid Chromatography-Tandem Mass Spectrometry
Evid Based Complement Alternat Med. 2021 Jul 8;2021:8864273. doi: 10.1155/2021/8864273. eCollection 2021.ABSTRACTTriptolide (TP) has shown potential in rheumatoid arthritis (RA) treatment, but the narrow therapeutic window limits its clinical application. In clinical practice, the compatibility of Tripterygium wilfordii and Paeonia lactiflora is often used to attenuate the toxicity of TP, but its compatibility mechanism has not been fully elucidated. The aim of this study was to investigate the pharmacokinetics and tissue distribution of a combined regimen of TP and paeoniflorin (PF) after transdermal administration in mal...
Source: Evidence-based Complementary and Alternative Medicine - July 26, 2021 Category: Complementary Medicine Authors: Yong-Mei Guan Qian Shen Liang-Fei He Li-Mei Chen Zhenzhong Zang Lili Liu Wei-Feng Zhu Chen Li-Hua Hong-Ning Liu Source Type: research

Structurally diversified ent-kaurane and abietane diterpenoids from the stems of Tripterygium wilfordii and their anti-inflammatory activity
Bioorg Chem. 2021 Jul 20;115:105178. doi: 10.1016/j.bioorg.2021.105178. Online ahead of print.ABSTRACTFour undescribed ent-kaurane diterpenoids, wilkaunoids A - D (1-4), and three undescribed abietane diterpenoids, wilabinoids A - C (13-15), along with thirteen known ones (5-12 and 16-20), were isolated from Tripterygium wilfordii. Their structures were elucidated by extensive spectroscopic methods, electroniccirculardichroism calculation, and X-ray diffraction analysis. Compounds 1 and 2 were a pair of C-19 epimers of ent-kaurane diterpenoids, featuring a rare 19,20-epoxy-19,20-dimethoxy-kaurane fragment. Compound 3 posse...
Source: Bioorganic Chemistry - July 25, 2021 Category: Chemistry Authors: Xiao-Qiong Zhou Si-Qi Li Cai-Ceng Liao Wei-Feng Dai Kai-Rui Rao Xiu-Rong Ma Rong-Tao Li Xuan-Qin Chen Source Type: research

Structurally diversified ent-kaurane and abietane diterpenoids from the stems of Tripterygium wilfordii and their anti-inflammatory activity
Bioorg Chem. 2021 Jul 20;115:105178. doi: 10.1016/j.bioorg.2021.105178. Online ahead of print.ABSTRACTFour undescribed ent-kaurane diterpenoids, wilkaunoids A - D (1-4), and three undescribed abietane diterpenoids, wilabinoids A - C (13-15), along with thirteen known ones (5-12 and 16-20), were isolated from Tripterygium wilfordii. Their structures were elucidated by extensive spectroscopic methods, electroniccirculardichroism calculation, and X-ray diffraction analysis. Compounds 1 and 2 were a pair of C-19 epimers of ent-kaurane diterpenoids, featuring a rare 19,20-epoxy-19,20-dimethoxy-kaurane fragment. Compound 3 posse...
Source: Bioorganic Chemistry - July 25, 2021 Category: Chemistry Authors: Xiao-Qiong Zhou Si-Qi Li Cai-Ceng Liao Wei-Feng Dai Kai-Rui Rao Xiu-Rong Ma Rong-Tao Li Xuan-Qin Chen Source Type: research

Structurally diversified ent-kaurane and abietane diterpenoids from the stems of Tripterygium wilfordii and their anti-inflammatory activity
Bioorg Chem. 2021 Jul 20;115:105178. doi: 10.1016/j.bioorg.2021.105178. Online ahead of print.ABSTRACTFour undescribed ent-kaurane diterpenoids, wilkaunoids A - D (1-4), and three undescribed abietane diterpenoids, wilabinoids A - C (13-15), along with thirteen known ones (5-12 and 16-20), were isolated from Tripterygium wilfordii. Their structures were elucidated by extensive spectroscopic methods, electroniccirculardichroism calculation, and X-ray diffraction analysis. Compounds 1 and 2 were a pair of C-19 epimers of ent-kaurane diterpenoids, featuring a rare 19,20-epoxy-19,20-dimethoxy-kaurane fragment. Compound 3 posse...
Source: Bioorganic Chemistry - July 25, 2021 Category: Chemistry Authors: Xiao-Qiong Zhou Si-Qi Li Cai-Ceng Liao Wei-Feng Dai Kai-Rui Rao Xiu-Rong Ma Rong-Tao Li Xuan-Qin Chen Source Type: research