IJERPH, Vol. 19, Pages 16685: Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model
In conclusion, we show that triptolide can attenuate muscular damage by inhibiting muscular oxidative stress and inflammation in a carrageenan-induced rat DOMS model. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - December 12, 2022 Category: Environmental Health Authors: Che-Chia Hsu Chin-Chuan Tsai Po-Yen Ko Ting-Hsien Kwan Ming-Yie Liu Po-Ting Wu I-Ming Jou Tags: Article Source Type: research
Combining multidimensional chromatography-mass spectrometry and feature-based molecular networking methods for the systematic characterization of compounds in the supercritical fluid extract of Tripterygium wilfordii Hook F
Analyst, 2023, Advance Article DOI: 10.1039/D2AN01471H, PaperBoquan Qu, Yanfang Liu, Aijin Shen, Zhimou Guo, Long Yu, Dian Liu, Feifei Huang, Ting Peng, Xinmiao Liang A total of 324 compounds were systematically characterized by feature-based molecular networking. This work provides an efficient strategy for the rapid discovery and characterization of unknown compounds in natural products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - November 30, 2022 Category: Chemistry Authors: Boquan Qu Source Type: research
Combining multidimensional chromatography-mass spectrometry and feature-based molecular networking methods for the systematic characterization of compounds in the supercritical fluid extract of Tripterygium wilfordii Hook F
Analyst, 2022, Advance Article DOI: 10.1039/D2AN01471H, PaperBoquan Qu, Yanfang Liu, Aijin Shen, Zhimou Guo, Long Yu, Dian Liu, Feifei Huang, Ting Peng, Xinmiao Liang A total of 324 compounds were systematically characterized by feature-based molecular networking. This work provides an efficient strategy for the rapid discovery and characterization of unknown compounds in natural products. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - November 28, 2022 Category: Chemistry Authors: Boquan Qu Source Type: research
Proteomics analysis reveals novel insights into the mechanism of hepatotoxicity induced by Tripterygium wilfordii multiglycoside in mice
Tripterygium wilfordii multiglycoside (GTW), extracted and purified from the peeled roots of T. wilfordii Hook.f. (TwHF), is a well-known traditional Chinese medicine and applied to various autoimmune diseases clinically. However, it has been reported to cause severe liver injury. At present, the mechanism underlying GTW-induced hepatotoxicity remain poorly defined. Here, we evaluated the effects of GTW on mouse liver and elucidated the associated mechanisms via label-free proteomics combined with bioinformatics analysis. Male C57BL/6J mice were randomly divided into normal group, a low-dose GTW (70 mg/kg) group and a hig...
Source: Frontiers in Pharmacology - November 17, 2022 Category: Drugs & Pharmacology Source Type: research
Triptolide exposure induces oxidative stress and decrease oocyte quality in mice
In conclusion, our findings suggest detrimental effects of triptolide on mouse oocytes and, thus, on female reproduction.PMID:36372154 | DOI:10.1016/j.toxicon.2022.106964 (Source: Toxicon)
Source: Toxicon - November 13, 2022 Category: Toxicology Authors: Qian-Qian Hao Zhi-Ran Xu Han Nie Feng-Xin Qiao Ming-Xin Sun Yue-Cen Liu Hai-Long Wang Zhong-Quan Qi Chang-Long Xu Yu Liu Source Type: research
Triptolide exposure induces oxidative stress and decrease oocyte quality in mice
In conclusion, our findings suggest detrimental effects of triptolide on mouse oocytes and, thus, on female reproduction.PMID:36372154 | DOI:10.1016/j.toxicon.2022.106964 (Source: Cancer Control)
Source: Cancer Control - November 13, 2022 Category: Cancer & Oncology Authors: Qian-Qian Hao Zhi-Ran Xu Han Nie Feng-Xin Qiao Ming-Xin Sun Yue-Cen Liu Hai-Long Wang Zhong-Quan Qi Chang-Long Xu Yu Liu Source Type: research
Connective tissue disease-related interstitial lung disease is alleviated by tripterine through inhibition of the PI3K/Akt, apoptosis, and TNF- α signalling pathways
Conclusions: This study preliminarily revealed the potential molecular biological mechanism of tripterine while treating CTD-ILD might be related to inhibiting the PI3K/Akt, apoptosis, and TNF-α signalling pathways. Tripterygium wilfordii Hook. F. and its extract could be used clinically for treating CTD-ILD. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 7, 2022 Category: Drugs & Pharmacology Source Type: research
Molecules, Vol. 27, Pages 7274: Immunosuppressive Sesquiterpene Pyridine Alkaloids from Tripterygium wilfordii Hook. f
In this study, ten new SPAs, wilfordatine A–J (1–10), were isolated from the roots of T. wilfordii, along with ten known analogues (11–20). Their structures were primarily elucidated by extensive 1D and 2D NMR spectroscopic analysis. To search for more immunosuppressive ingredients related to the clinical efficacy of T. wilfordii, the total alkaloids (TA) and compounds 4, 5, and 9–16 were tested for their inhibitory effects on nuclear factor-kappa B (NF-κB) pathway in Lipopolysaccharide (LPS) induced HEK293/NF-κB-Luc cells. Among them, TA, ...
Source: Molecules - October 26, 2022 Category: Chemistry Authors: Yadan Wang Jiangong Yan Zhongmou Zhang Minghui Chen Xianfu Wu Shuangcheng Ma Tags: Article Source Type: research
A metabolomic approach to study triptolide-induced ovarian damage in rats
Toxicology. 2022 Oct 19:153351. doi: 10.1016/j.tox.2022.153351. Online ahead of print.ABSTRACTTriptolide (TP) is the major active ingredient of Tripterygium wilfordii Hook, a traditional Chinese herb that possesses various pharmacological activities and has been used to treat autoimmune and inflammatory diseases for thousands of years. However, the clinical application of TP is limited due to its multiorgan toxicity, and in particular, its negative impact on female fertility. To date, the specific toxic mechanisms on reproduction induced by TP remain unclear. In the current study, an LC-MS/MS-based metabolomic approach was...
Source: Toxicology - October 22, 2022 Category: Toxicology Authors: Feng Zhou Lu Lu Zhong Yang Tan Li Liu Gang Pei Source Type: research
MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells
In this study, we found that mitoQ significantly activated p62-Nrf2 signaling pathway in H9c2 cells with or without TP treatment. Moreover, knockdown of p62 or Nrf2 could block the protective effect of mitoQ against TP in H9c2 cells. Taken together, our study demonstrates that mitoQ can alleviate TP-induced cardiotoxicity via the activation of p62-Nrf2 signaling pathway, which provides new potential strategies to combat TP-induced cardiomyocyte toxicity.PMID:36272531 | DOI:10.1016/j.tiv.2022.105487 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - October 22, 2022 Category: Toxicology Authors: Guoyao Tan Zhiyan Qin Shiqin Jiang Lei Zhang Gengyi Zhang Min Huang Zhiying Huang Jing Jin Source Type: research
A metabolomic approach to study triptolide-induced ovarian damage in rats
Toxicology. 2022 Oct 19:153351. doi: 10.1016/j.tox.2022.153351. Online ahead of print.ABSTRACTTriptolide (TP) is the major active ingredient of Tripterygium wilfordii Hook, a traditional Chinese herb that possesses various pharmacological activities and has been used to treat autoimmune and inflammatory diseases for thousands of years. However, the clinical application of TP is limited due to its multiorgan toxicity, and in particular, its negative impact on female fertility. To date, the specific toxic mechanisms on reproduction induced by TP remain unclear. In the current study, an LC-MS/MS-based metabolomic approach was...
Source: Toxicology - October 22, 2022 Category: Toxicology Authors: Feng Zhou Lu Lu Zhong Yang Tan Li Liu Gang Pei Source Type: research
MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells
In this study, we found that mitoQ significantly activated p62-Nrf2 signaling pathway in H9c2 cells with or without TP treatment. Moreover, knockdown of p62 or Nrf2 could block the protective effect of mitoQ against TP in H9c2 cells. Taken together, our study demonstrates that mitoQ can alleviate TP-induced cardiotoxicity via the activation of p62-Nrf2 signaling pathway, which provides new potential strategies to combat TP-induced cardiomyocyte toxicity.PMID:36272531 | DOI:10.1016/j.tiv.2022.105487 (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - October 22, 2022 Category: Toxicology Authors: Guoyao Tan Zhiyan Qin Shiqin Jiang Lei Zhang Gengyi Zhang Min Huang Zhiying Huang Jing Jin Source Type: research
A metabolomic approach to study triptolide-induced ovarian damage in rats
Toxicology. 2022 Oct 19:153351. doi: 10.1016/j.tox.2022.153351. Online ahead of print.ABSTRACTTriptolide (TP) is the major active ingredient of Tripterygium wilfordii Hook, a traditional Chinese herb that possesses various pharmacological activities and has been used to treat autoimmune and inflammatory diseases for thousands of years. However, the clinical application of TP is limited due to its multiorgan toxicity, and in particular, its negative impact on female fertility. To date, the specific toxic mechanisms on reproduction induced by TP remain unclear. In the current study, an LC-MS/MS-based metabolomic approach was...
Source: Toxicology - October 22, 2022 Category: Toxicology Authors: Feng Zhou Lu Lu Zhong Yang Tan Li Liu Gang Pei Source Type: research
Efficacy and safety of Tripterygium wilfordii polyglycosides for diabetic kidney disease: an overview of systematic reviews and meta-analyses
ConclusionTWP appears effective for DKD on improving proteinuria and increasing the level of serum albumin, accompanied by a higher risk of adverse events. The evidence would be more credible and valuable to guide decision if the quality of the SRs and primary studies is improved.Systematic review registrationPROSPERO CRD42021249560 (Source: Systematic Reviews)
Source: Systematic Reviews - October 21, 2022 Category: International Medicine & Public Health Source Type: research
Therapeutic potential of demethylzeylasteral, a triterpenoid of the genus Tripterygium wilfordii
Fitoterapia. 2022 Oct 13:105333. doi: 10.1016/j.fitote.2022.105333. Online ahead of print.ABSTRACTPentacyclic triterpenoids are important natural products widely presenting in nature with rich bioactivities. Tripterygium wilfordii Hook. f., a precious Chinese medicinal material, is used to cure rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus. Triterpenoids are one of the important active components of Tripterygium wilfordii Hook. f. Demethylzeylasteral extracted from Tripterygium wilfordii Hook. f. had numerous pharmacological effects, including anticancer, anti-inflammatory, immune suppression, anti...
Source: Fitoterapia - October 16, 2022 Category: Biochemistry Authors: Xiaojing Sun Binyu Shen Hui Yu Wenhui Wu Ruilong Sheng Yiwen Fang Ruihua Guo Source Type: research
