TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP
In conclusion, TP presensitizes hepatocytes and enhances the sensitivity of hepatocytes to the Fas/FasL pathway by inhibiting the protein expression of XIAP, leading to hepatocyte apoptosis.PMID:37944651 | DOI:10.1016/j.toxlet.2023.11.001 (Source: Toxicology Letters)
Source: Toxicology Letters - November 9, 2023 Category: Toxicology Authors: Xue Fan Yangping Zhu Shuang Peng Yingying Miao Qian Lu Luyong Zhang Zhenzhou Jiang Qinwei Yu Source Type: research
TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP
In conclusion, TP presensitizes hepatocytes and enhances the sensitivity of hepatocytes to the Fas/FasL pathway by inhibiting the protein expression of XIAP, leading to hepatocyte apoptosis.PMID:37944651 | DOI:10.1016/j.toxlet.2023.11.001 (Source: Toxicology Letters)
Source: Toxicology Letters - November 9, 2023 Category: Toxicology Authors: Xue Fan Yangping Zhu Shuang Peng Yingying Miao Qian Lu Luyong Zhang Zhenzhou Jiang Qinwei Yu Source Type: research
TP induces hepatic intolerance to FasL-mediated hepatocyte apoptosis by inhibiting XIAP
In conclusion, TP presensitizes hepatocytes and enhances the sensitivity of hepatocytes to the Fas/FasL pathway by inhibiting the protein expression of XIAP, leading to hepatocyte apoptosis.PMID:37944651 | DOI:10.1016/j.toxlet.2023.11.001 (Source: Toxicology Letters)
Source: Toxicology Letters - November 9, 2023 Category: Toxicology Authors: Xue Fan Yangping Zhu Shuang Peng Yingying Miao Qian Lu Luyong Zhang Zhenzhou Jiang Qinwei Yu Source Type: research
A comprehensive review of Tripterygium wilfordii hook. f. in the treatment of rheumatic and autoimmune diseases: Bioactive compounds, mechanisms of action, and future directions
Rheumatic and autoimmune diseases are a group of immune system-related disorders wherein the immune system mistakenly attacks and damages the body’s tissues and organs. This excessive immune response leads to inflammation, tissue damage, and functional impairment. Therapeutic approaches typically involve medications that regulate immune responses, reduce inflammation, alleviate symptoms, and target specific damaged organs. Tripterygium wilfordii Hook. f., a traditional Chinese medicinal plant, has been widely studied in recent years for its application in the treatment of autoimmune diseases, including rheumatoid arthrit...
Source: Frontiers in Pharmacology - November 1, 2023 Category: Drugs & Pharmacology Source Type: research
Inhibiting NF- κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer
This study aims to identify crucial targets and mechanisms of demethylzeylasteral in treating colon cancer, making it a promising candidate for anti-tumor therapy. Through gene knockout, overexpression techniques, and double Luciferase experiments, we confirmed that demethylzeylasteral reduces S100A11 expression in HT29 cells and in vivo tumor models to anti-colon cancer. By conducting Surface Plasmon Resonance, immunofluorescence staining, and confocal laser microscopy observations, we verified the direct interaction between demethylzeylasteral and S100A11, and explored the impact of S100A11's subcellular localization on ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 25, 2023 Category: Drugs & Pharmacology Authors: Wenqing Li Fubo Han Kaifan Tang Chengjie Ding Fen Xiong Yina Xiao Chen Li Qian Liang Kwang Youl Lee Ik-Soo Lee Hongchang Gao Source Type: research
Inhibiting NF- κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer
This study aims to identify crucial targets and mechanisms of demethylzeylasteral in treating colon cancer, making it a promising candidate for anti-tumor therapy. Through gene knockout, overexpression techniques, and double Luciferase experiments, we confirmed that demethylzeylasteral reduces S100A11 expression in HT29 cells and in vivo tumor models to anti-colon cancer. By conducting Surface Plasmon Resonance, immunofluorescence staining, and confocal laser microscopy observations, we verified the direct interaction between demethylzeylasteral and S100A11, and explored the impact of S100A11's subcellular localization on ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 25, 2023 Category: Drugs & Pharmacology Authors: Wenqing Li Fubo Han Kaifan Tang Chengjie Ding Fen Xiong Yina Xiao Chen Li Qian Liang Kwang Youl Lee Ik-Soo Lee Hongchang Gao Source Type: research
Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC
In this study, we determined the first cryogenic electron microscopy structure of a plant OSC, friedelin synthase, from Tripterygium wilfordii Hook. f (TwOSC). We also performed quantum mechanics/molecular mechanics simulations to reveal the energy profile for the CSR cascade reaction and identify key residues crucial for PT skeleton yield. Furthermore, we semi-rationally designed two TwOSC mutants, which significantly improved the yields of friedelin and β-amyrin, respectively. Our findings provide novel insights into the CSR mechanism under TwOSC enzyme catalysis and propose a new strategy for the semi-rational design o...
Source: Angewandte Chemie - October 16, 2023 Category: Chemistry Authors: Yunfeng Luo Xiaoli Ma Yufan Qiu Yun Lu Siyu Shen Yang Li Haiyun Gao Kang Chen Jiawei Zhou Tianyuan Hu Lichan Tu Huan Zhao Dan Li Faqiang Leng Wei Gao Tao Jiang Changli Liu Luqi Huang Ruibo Wu Yuru Tong Source Type: research
Structural and Catalytic Insight into the Unique Pentacyclic Triterpene Synthase TwOSC
In this study, we determined the first cryogenic electron microscopy structure of a plant OSC, friedelin synthase, from Tripterygium wilfordii Hook. f (TwOSC). We also performed quantum mechanics/molecular mechanics simulations to reveal the energy profile for the CSR cascade reaction and identify key residues crucial for PT skeleton yield. Furthermore, we semi-rationally designed two TwOSC mutants, which significantly improved the yields of friedelin and β-amyrin, respectively. Our findings provide novel insights into the CSR mechanism under TwOSC enzyme catalysis and propose a new strategy for the semi-rational design o...
Source: Angewandte Chemie - October 16, 2023 Category: Chemistry Authors: Yunfeng Luo Xiaoli Ma Yufan Qiu Yun Lu Siyu Shen Yang Li Haiyun Gao Kang Chen Jiawei Zhou Tianyuan Hu Lichan Tu Huan Zhao Dan Li Faqiang Leng Wei Gao Tao Jiang Changli Liu Luqi Huang Ruibo Wu Yuru Tong Source Type: research
Dihydro- β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities
Bioorg Chem. 2023 Sep 26;141:106886. doi: 10.1016/j.bioorg.2023.106886. Online ahead of print.ABSTRACTExtensive phytochemical investigation of the seeds of Tripterygium wilfordii led to the identification of 54 polyesterified dihydro-β-agarofuran-type sesquiterpenoids, including 27 previously undescribed ones, named Tripwilin I-XXVII (1-27). Comprehensive spectroscopic and single-crystal X-ray diffraction analyses, along with electronic circular dichroism (ECD) calculations were used for the structural elucidation of the new compounds. Biological assay revealed that 37 compounds among the isolates exhibited significant in...
Source: Bioorganic Chemistry - October 1, 2023 Category: Chemistry Authors: Guangchao Cao Ruonan Ning Jie Zhao Jiaying Yao Linyue Chang Hongyan Mu Rujun Zhang Zhenhua Chen Fengbei Gong Shijun He Min Jiang Weimin Zhao Source Type: research
Dihydro- β-agarofuran-type sesquiterpenoids from the seeds of Tripterygium wilfordii (Thunder God Vine) and evaluation of their anti-osteoclastogenesis and immunosuppressive activities
Bioorg Chem. 2023 Sep 26;141:106886. doi: 10.1016/j.bioorg.2023.106886. Online ahead of print.ABSTRACTExtensive phytochemical investigation of the seeds of Tripterygium wilfordii led to the identification of 54 polyesterified dihydro-β-agarofuran-type sesquiterpenoids, including 27 previously undescribed ones, named Tripwilin I-XXVII (1-27). Comprehensive spectroscopic and single-crystal X-ray diffraction analyses, along with electronic circular dichroism (ECD) calculations were used for the structural elucidation of the new compounds. Biological assay revealed that 37 compounds among the isolates exhibited significant in...
Source: Bioorganic Chemistry - October 1, 2023 Category: Chemistry Authors: Guangchao Cao Ruonan Ning Jie Zhao Jiaying Yao Linyue Chang Hongyan Mu Rujun Zhang Zhenhua Chen Fengbei Gong Shijun He Min Jiang Weimin Zhao Source Type: research
The Promising Therapeutic Potential of Celastrol for Fibrotic Diseases: A Systematic Literature Review on Its Mechanism
Cureus. 2023 Aug 28;15(8):e44269. doi: 10.7759/cureus.44269. eCollection 2023 Aug.ABSTRACTCelastrol is a pentacyclic tripterine sourced from Tripterygium wilfordii hook root. Celastrol can exert certain biological functions such as antitumor, anti-inflammatory, and antiproliferative properties. Celastrol was shown from the previous literature to be capable of attenuating many fibrotic diseases. As the effects of various fibrotic diseases such as atherosclerosis, cancer, and ischemia affect more people with devastating repercussions, this warrants celastrol to be exploited as a phytotherapeutic drug. The purpose of this stu...
Source: Atherosclerosis - September 29, 2023 Category: Cardiology Authors: Nurin Yasmin Mohd Khairudin Nasibah Azme Nurdiyana Nasrudin Siti Aznida Ab Karim Source Type: research
The Promising Therapeutic Potential of Celastrol for Fibrotic Diseases: A Systematic Literature Review on Its Mechanism
Cureus. 2023 Aug 28;15(8):e44269. doi: 10.7759/cureus.44269. eCollection 2023 Aug.ABSTRACTCelastrol is a pentacyclic tripterine sourced from Tripterygium wilfordii hook root. Celastrol can exert certain biological functions such as antitumor, anti-inflammatory, and antiproliferative properties. Celastrol was shown from the previous literature to be capable of attenuating many fibrotic diseases. As the effects of various fibrotic diseases such as atherosclerosis, cancer, and ischemia affect more people with devastating repercussions, this warrants celastrol to be exploited as a phytotherapeutic drug. The purpose of this stu...
Source: Atherosclerosis - September 29, 2023 Category: Cardiology Authors: Nurin Yasmin Mohd Khairudin Nasibah Azme Nurdiyana Nasrudin Siti Aznida Ab Karim Source Type: research
GSE242307 Mechanisms of triptolide's anti-pancreatic cancer effects through inhibition of autophagy and extracellular matrix activation
In conclusion, triptolide exerted its inhibitory effects on pancreatic cancer cell growth and stromal cell activation through the inhibition of CXCL1 and TGF-β1. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - September 9, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Celastrol attenuates human parvovirus B19 NS1 ‑induced NLRP3 inflammasome activation in macrophages
Mol Med Rep. 2023 Oct;28(4):193. doi: 10.3892/mmr.2023.13080. Epub 2023 Sep 1.ABSTRACTHuman parvovirus B19 (B19V) has been strongly associated with a variety of inflammatory disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease and systemic lupus erythematosus. Non‑structural protein 1 (NS1) of B19V has been demonstrated to play essential roles in the pathological processes of B19V infection due to its regulatory properties on inflammatory cytokines. Celastrol, a quinone methide isolated from Tripterygium wilfordii, has displayed substantial potential in treating inflammatory diseases, such as psoriasi...
Source: Molecular Medicine Reports - September 1, 2023 Category: Molecular Biology Authors: Chang-Lun Huang Der-Yuan Chen Chih-Chen Tzang Jhen-Wei Lin Bor-Show Tzang Tsai-Ching Hsu Source Type: research
Celastrol attenuates human parvovirus B19 NS1 ‑induced NLRP3 inflammasome activation in macrophages
Mol Med Rep. 2023 Oct;28(4):193. doi: 10.3892/mmr.2023.13080. Epub 2023 Sep 1.ABSTRACTHuman parvovirus B19 (B19V) has been strongly associated with a variety of inflammatory disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease and systemic lupus erythematosus. Non‑structural protein 1 (NS1) of B19V has been demonstrated to play essential roles in the pathological processes of B19V infection due to its regulatory properties on inflammatory cytokines. Celastrol, a quinone methide isolated from Tripterygium wilfordii, has displayed substantial potential in treating inflammatory diseases, such as psoriasi...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Chang-Lun Huang Der-Yuan Chen Chih-Chen Tzang Jhen-Wei Lin Bor-Show Tzang Tsai-Ching Hsu Source Type: research
