GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

Celastrol: The new dawn in the treatment of vascular remodeling diseases
Biomed Pharmacother. 2023 Feb;158:114177. doi: 10.1016/j.biopha.2022.114177. Epub 2023 Jan 3.ABSTRACTEvidence is mounting that abnormal vascular remodeling leads to many cardiovascular diseases (CVDs). This suggests that vascular remodeling can be a crucial target for the prevention and treatment of CVDs. Recently, celastrol, an active ingredient of the broadly used Chinese herb Tripterygium wilfordii Hook F, has attracted extensive interest for its proven potential to improve vascular remodeling. Substantial evidence has shown that celastrol improves vascular remodeling by ameliorating inflammation, hyperproliferation, an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 22, 2023 Category: Drugs & Pharmacology Authors: Jun-Lan Tan Jian Yi Xian-Ya Cao Fei-Ying Wang Si-Lin Xie Ling-Ling Zhou Li Qin Ai-Guo Dai Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

GSH-specific fluorescent probe for sensing, bioimaging, rapid screening of natural inhibitor Celastrol and ccRCC theranostics
In this study, an off-on fluorescent probe (NBD-P) is developed for selective and sensitive sensing GSH. NBD-P has a good cell membrane permeability that can be applied in bioimaging endogenous GSH in living cells. Moreover, the NBD-P probe is used to visualize GSH in animal models. In addition, a rapid drug screening method is successfully established using the fluorescent probe NBD-P. A potent natural inhibitor of GSH is identified as Celastrol from Tripterygium wilfordii Hook F, which effectively triggers mitochondrial apoptosis in clear cell renal cell carcinoma (ccRCC). More importantly, NBD-P can selectively respond ...
Source: Analytica Chimica Acta - February 22, 2023 Category: Chemistry Authors: Chanjuan Zhang Yan Qin Changfeng Deng Neng Zhu Yaning Shi Wei Wang Li Qin Source Type: research

Molecular mechanism of Cuscutae semen –radix rehmanniae praeparata in relieving reproductive injury of male rats induced with tripterygium wilfordii multiglycosides: A tandem mass tag-based proteomics analysis
Conclusion: Cuscutae semen and Radix rehmanniae praeparata may regulate the PPAR signaling pathway mediated Acsl1, Plin1 and PPARγ to reduce the testicular tissue damage of male rats caused by GTW. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 17, 2023 Category: Drugs & Pharmacology Source Type: research

Celastrol-regulated gut microbiota and bile acid metabolism alleviate hepatocellular carcinoma proliferation by regulating the interaction between FXR and RXR α in vivo and in vitro
In conclusion, the findings of this study suggest that celastrol exerts an alleviating effect on HCC, in part via regulation of the B. fragilis-GUDCA-FXR/RXRα-mTOR axis. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - February 15, 2023 Category: Drugs & Pharmacology Source Type: research

Inhibition of Mast Cell Degranulation in Atopic Dermatitis by Celastrol through Suppressing MRGPRX2
CONCLUSION: We found that the improvements of atopic dermatitis caused by Celastrol were reversed by treatment with MRGPRX2OE, indicating that Celastrol might affect atopic dermatitis through MRGPRX2. This study might provide a novel thought for the prevention and treatment of atopic dermatitis by regulating MRGPRX2.PMID:36712922 | PMC:PMC9876689 | DOI:10.1155/2023/9049256 (Source: Disease Markers)
Source: Disease Markers - January 30, 2023 Category: Laboratory Medicine Authors: Ciyu Yao Wenzhen Ye Mengxue Chen Source Type: research

Tripterygium wilfordii Hook.f. ameliorates paraquat-induced lung injury by reducing oxidative stress and ferroptosis via Nrf2/HO-1 pathway
In conclusion, our study demonstrated the potential of TwHF as a treatment for PQ-induced lung injury and fibrosis. The protective mechanism of this medicinal herb may involve the regulation of ferroptosis.PMID:36706526 | DOI:10.1016/j.ecoenv.2023.114575 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - January 27, 2023 Category: Environmental Health Authors: Cong-Ying Song Meng-Xiao Feng Li Li Ping Wang Xuan Lu Yuan-Qiang Lu Source Type: research