Guilu-Erxian-Glue alleviates < em > Tripterygium wilfordii < /em > polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway
CONCLUSIONS: Ferroptosis resistance from GLEXG might be driven by activation of the Keap1/Nrf2/GPX4 pathway. Targeting ferroptosis is a novel approach for OAS therapy.PMID:36688426 | PMC:PMC9873281 | DOI:10.1080/13880209.2023.2165114 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 23, 2023 Category: Drugs & Pharmacology Authors: Jin Ding Baowei Lu Lumei Liu Zixuan Zhong Neng Wang Bonan Li Wen Sheng Qinghu He Source Type: research
Guilu-Erxian-Glue alleviates < em > Tripterygium wilfordii < /em > polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway
CONCLUSIONS: Ferroptosis resistance from GLEXG might be driven by activation of the Keap1/Nrf2/GPX4 pathway. Targeting ferroptosis is a novel approach for OAS therapy.PMID:36688426 | DOI:10.1080/13880209.2023.2165114 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - January 23, 2023 Category: Drugs & Pharmacology Authors: Jin Ding Baowei Lu Lumei Liu Zixuan Zhong Neng Wang Bonan Li Wen Sheng Qinghu He Source Type: research
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling
This study aimed to examine the anticancer properties of triptonide in human hepatocellular carcinoma (HCC). HCC cells were administered with triptonide at various levels, and CCK-8 and colony formation assays were carried out for detecting HCC cell proliferation. Then, cell apoptosis and cell cycle distribution were evaluated by flow cytometry. Tumor growth was monitored noninvasively by ultrasound imaging. Cell migration and invasion were quantitated by wound healing and Transwell assays. A metastasis model was established via tail vein injection of HCC cells in nude mice. Immunoblot was performed to quantitate the expre...
Source: Neoplasma - January 13, 2023 Category: Cancer & Oncology Authors: Hao Zhang Yingxuan Mao Xiaomeng Zou Jiamei Niu Jian Jiang Xi Chen Mingwei Zhu Xiuhua Yang Tianxiu Dong Source Type: research
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling
This study aimed to examine the anticancer properties of triptonide in human hepatocellular carcinoma (HCC). HCC cells were administered with triptonide at various levels, and CCK-8 and colony formation assays were carried out for detecting HCC cell proliferation. Then, cell apoptosis and cell cycle distribution were evaluated by flow cytometry. Tumor growth was monitored noninvasively by ultrasound imaging. Cell migration and invasion were quantitated by wound healing and Transwell assays. A metastasis model was established via tail vein injection of HCC cells in nude mice. Immunoblot was performed to quantitate the expre...
Source: Neoplasma - January 13, 2023 Category: Cancer & Oncology Authors: Hao Zhang Yingxuan Mao Xiaomeng Zou Jiamei Niu Jian Jiang Xi Chen Mingwei Zhu Xiuhua Yang Tianxiu Dong Source Type: research
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling
This study aimed to examine the anticancer properties of triptonide in human hepatocellular carcinoma (HCC). HCC cells were administered with triptonide at various levels, and CCK-8 and colony formation assays were carried out for detecting HCC cell proliferation. Then, cell apoptosis and cell cycle distribution were evaluated by flow cytometry. Tumor growth was monitored noninvasively by ultrasound imaging. Cell migration and invasion were quantitated by wound healing and Transwell assays. A metastasis model was established via tail vein injection of HCC cells in nude mice. Immunoblot was performed to quantitate the expre...
Source: Neoplasma - January 13, 2023 Category: Cancer & Oncology Authors: Hao Zhang Yingxuan Mao Xiaomeng Zou Jiamei Niu Jian Jiang Xi Chen Mingwei Zhu Xiuhua Yang Tianxiu Dong Source Type: research
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling
This study aimed to examine the anticancer properties of triptonide in human hepatocellular carcinoma (HCC). HCC cells were administered with triptonide at various levels, and CCK-8 and colony formation assays were carried out for detecting HCC cell proliferation. Then, cell apoptosis and cell cycle distribution were evaluated by flow cytometry. Tumor growth was monitored noninvasively by ultrasound imaging. Cell migration and invasion were quantitated by wound healing and Transwell assays. A metastasis model was established via tail vein injection of HCC cells in nude mice. Immunoblot was performed to quantitate the expre...
Source: Neoplasma - January 13, 2023 Category: Cancer & Oncology Authors: Hao Zhang Yingxuan Mao Xiaomeng Zou Jiamei Niu Jian Jiang Xi Chen Mingwei Zhu Xiuhua Yang Tianxiu Dong Source Type: research
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling
This study aimed to examine the anticancer properties of triptonide in human hepatocellular carcinoma (HCC). HCC cells were administered with triptonide at various levels, and CCK-8 and colony formation assays were carried out for detecting HCC cell proliferation. Then, cell apoptosis and cell cycle distribution were evaluated by flow cytometry. Tumor growth was monitored noninvasively by ultrasound imaging. Cell migration and invasion were quantitated by wound healing and Transwell assays. A metastasis model was established via tail vein injection of HCC cells in nude mice. Immunoblot was performed to quantitate the expre...
Source: Neoplasma - January 13, 2023 Category: Cancer & Oncology Authors: Hao Zhang Yingxuan Mao Xiaomeng Zou Jiamei Niu Jian Jiang Xi Chen Mingwei Zhu Xiuhua Yang Tianxiu Dong Source Type: research
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling
This study aimed to examine the anticancer properties of triptonide in human hepatocellular carcinoma (HCC). HCC cells were administered with triptonide at various levels, and CCK-8 and colony formation assays were carried out for detecting HCC cell proliferation. Then, cell apoptosis and cell cycle distribution were evaluated by flow cytometry. Tumor growth was monitored noninvasively by ultrasound imaging. Cell migration and invasion were quantitated by wound healing and Transwell assays. A metastasis model was established via tail vein injection of HCC cells in nude mice. Immunoblot was performed to quantitate the expre...
Source: Neoplasma - January 13, 2023 Category: Cancer & Oncology Authors: Hao Zhang Yingxuan Mao Xiaomeng Zou Jiamei Niu Jian Jiang Xi Chen Mingwei Zhu Xiuhua Yang Tianxiu Dong Source Type: research
Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns
Tripterygium wilfordii Hook. F. (TwHF), a traditional Chinese medicine, is widely used in the treatment of rheumatoid arthritis. Due to multiorgan toxicity, particularly hepatotoxicity, the application of TwHF i... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - January 10, 2023 Category: Complementary Medicine Authors: Meng Li, Qiong Luo, Xi Chen, Furong Qiu, Yanyan Tao, Xin Sun and Chenghai Liu Tags: Research Source Type: research
Two new chemical constituents from the stem and branch of Tripterygium wilfordii
. (Source: Journal of Asian Natural Products Research)
Source: Journal of Asian Natural Products Research - January 9, 2023 Category: Complementary Medicine Authors: Ya-Lin Hu Bo Hu Tian-Qi Xu Hong-Yu Li Huai-Yu Cheng Xia Zhang Wei Xu Chun-Lin Fan Guang-Xiong Zhou Source Type: research
Molecules, Vol. 28, Pages 553: Pharmacokinetic Study of Triptolide Nanocarrier in Transdermal Drug Delivery System & mdash;Combination of Experiment and Mathematical Modeling
This study shows that the three&minus;layer model can be used for transdermal drug delivery system drug diffusion research. Therefore, it is profitable for transdermal drug delivery system design and the optimization of the dosage form. Based on the drug concentration of the in vivo microdialysis measurement technology, the diffusion coefficient of drugs in the skin can be more accurately measured, and the numerical results can be verified. Therefore, the microdialysis technique combined with mathematical modeling provides a very good platform for the further study of transdermal delivery systems. This research wil...
Source: Molecules - January 5, 2023 Category: Chemistry Authors: Yang Meng Han Yu Fan Yuan Tags: Article Source Type: research
GSE198630 Gene expression of colorectal cancer cells treated with Celastrol or compound 19-048
Contributors : Hao Zhang ; Hongfang Zhao ; Heng Xu ; Cheng LuoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensAs a terpenoids natural product isolated from the plant Thunder God Vine, Celastrol is widely studied for its pharmacological activities, including anti-tumor activities. However, the clinical application of Celastrol is strictly limited due to its severe side effects. Without identification and validation of the target protein of Celastrol, it is difficult to determine whether its anti-tumor activities and side effects are due to inhibition of the same protein. Using a ne...
Source: GEO: Gene Expression Omnibus - December 31, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Protective effect of Qingluotongbi formula against < em > Tripterygium wilfordii < /em > induced liver injury in mice by improving fatty acid β-oxidation and mitochondrial biosynthesis
Pharm Biol. 2023 Dec;61(1):80-88. doi: 10.1080/13880209.2022.2157842.NO ABSTRACTPMID:36541729 | DOI:10.1080/13880209.2022.2157842 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - December 21, 2022 Category: Drugs & Pharmacology Authors: Jie Zhou Ming Li Zhichao Yu Changqing Li Lingling Zhou Xueping Zhou Source Type: research
