Daytime Aspartame Intake Results in Larger Influences on Body Weight, Serum Corticosterone Level, Serum/Cerebral Cytokines Levels and Depressive-Like Behaviors in Mice than Nighttime Intake
In this study, healthy adult C57BL/6 mice were randomly divided into four groups: Control group (CON), oral gavage sham group (OGS), daytime APM intragastric group (DAI) and nighttime APM intragastric group (NAI). DAI and NAI groups were given 80mg/kg body weight daily for 4 weeks. We found that DAI and NAI groups had significantly increased mean body weight, higher serum corticosterone levels, up-regulated pro-inflammatory responses in serum and brain, and exacerbated depressive-like behaviors than the CON and the two APM intake groups. Moreover, all these changes induced by APM intake were more significant in the DAI gro...
Source: Neurotoxicology - March 18, 2024 Category: Neurology Authors: Haiyuan Ma Jiapeng Deng Jing Liu Xiaobao Jin Junhua Yang Source Type: research
Daytime aspartame intake results in larger influences on body weight, serum corticosterone level, serum/cerebral cytokines levels and depressive-like behaviors in mice than nighttime intake
In this study, healthy adult C57BL/6 mice were randomly divided into four groups: Control group (CON), oral gavage sham group (OGS), daytime APM intragastric group (DAI) and nighttime APM intragastric group (NAI). DAI and NAI groups were given 80 mg/kg body weight daily for 4 weeks. We found that DAI and NAI groups had significantly increased mean body weight, higher serum corticosterone levels, up-regulated pro-inflammatory responses in serum and brain, and exacerbated depressive-like behaviors than the CON and the two APM intake groups. Moreover, all these changes induced by APM intake were more significant in the DAI gr...
Source: Neurotoxicology - March 18, 2024 Category: Neurology Authors: Haiyuan Ma Jiapeng Deng Jing Liu Xiaobao Jin Junhua Yang Source Type: research
Thiazolidinediones Are Partially Effective Bitter Blockers
In this study, 2 TZDs were tested, rosiglitazone (ROSI) and a simpler form of TZD, using a high-potency sweetener as a positive control (neohesperidin dihydrochalcone, NHDC). We tested bitter-blocking effects using the bitter drugs tenofovir alafenamide fumarate (TAF), a treatment for HIV and hepatitis B infection, and praziquantel (PRAZ), a treatment for schistosomiasis, by conducting taste testing with 2 separate taste panels: a general panel (N = 97, 20-23 years, 82.5% female, all Eastern European) and a genetically informative panel (N = 158, including 68 twin pairs, 18-82 years, 76% female, 87% European ancestry). Par...
Source: Clinical Therapeutics - March 10, 2024 Category: Drugs & Pharmacology Authors: Ha Nguyen Cailu Lin Ivona Sasimovich Katherine Bell Amy Huang Emilia Leszkowicz Nancy E Rawson Danielle R Reed Source Type: research
Thiazolidinediones Are Partially Effective Bitter Blockers
In this study, 2 TZDs were tested, rosiglitazone (ROSI) and a simpler form of TZD, using a high-potency sweetener as a positive control (neohesperidin dihydrochalcone, NHDC). We tested bitter-blocking effects using the bitter drugs tenofovir alafenamide fumarate (TAF), a treatment for HIV and hepatitis B infection, and praziquantel (PRAZ), a treatment for schistosomiasis, by conducting taste testing with 2 separate taste panels: a general panel (N = 97, 20-23 years, 82.5% female, all Eastern European) and a genetically informative panel (N = 158, including 68 twin pairs, 18-82 years, 76% female, 87% European ancestry). Par...
Source: Clinical Therapeutics - March 10, 2024 Category: Drugs & Pharmacology Authors: Ha Nguyen Cailu Lin Ivona Sasimovich Katherine Bell Amy Huang Emilia Leszkowicz Nancy E Rawson Danielle R Reed Source Type: research
Thiazolidinediones Are Partially Effective Bitter Blockers
In this study, 2 TZDs were tested, rosiglitazone (ROSI) and a simpler form of TZD, using a high-potency sweetener as a positive control (neohesperidin dihydrochalcone, NHDC). We tested bitter-blocking effects using the bitter drugs tenofovir alafenamide fumarate (TAF), a treatment for HIV and hepatitis B infection, and praziquantel (PRAZ), a treatment for schistosomiasis, by conducting taste testing with 2 separate taste panels: a general panel (N = 97, 20-23 years, 82.5% female, all Eastern European) and a genetically informative panel (N = 158, including 68 twin pairs, 18-82 years, 76% female, 87% European ancestry). Par...
Source: Clinical Therapeutics - March 10, 2024 Category: Drugs & Pharmacology Authors: Ha Nguyen Cailu Lin Ivona Sasimovich Katherine Bell Amy Huang Emilia Leszkowicz Nancy E Rawson Danielle R Reed Source Type: research
Microbial synthesis of terpenoids for human nutrition - an emerging field with high business potential
Curr Opin Biotechnol. 2024 Mar 5;87:103099. doi: 10.1016/j.copbio.2024.103099. Online ahead of print.ABSTRACTBecause of their complicated biosynthesis and hydrophobic nature, fermentative production of terpenoids did not play a significant role on a commercial scale until a few years ago. Driven by technological progress in metabolic engineering and process biotechnology, terpene-based food ingredients such as flavors, sweeteners, and vitamins produced by fermentation have now become viable and commercially competitive options. In recent years, several companies have developed microbial platforms for commercial terpene pro...
Source: Current Opinion in Biotechnology - March 6, 2024 Category: Biotechnology Authors: Jules Beekwilder Florence M Schempp Matthew Q Styles Oskar Zelder Source Type: research
Microbial synthesis of terpenoids for human nutrition - an emerging field with high business potential
Curr Opin Biotechnol. 2024 Mar 5;87:103099. doi: 10.1016/j.copbio.2024.103099. Online ahead of print.ABSTRACTBecause of their complicated biosynthesis and hydrophobic nature, fermentative production of terpenoids did not play a significant role on a commercial scale until a few years ago. Driven by technological progress in metabolic engineering and process biotechnology, terpene-based food ingredients such as flavors, sweeteners, and vitamins produced by fermentation have now become viable and commercially competitive options. In recent years, several companies have developed microbial platforms for commercial terpene pro...
Source: Current Opinion in Biotechnology - March 6, 2024 Category: Biotechnology Authors: Jules Beekwilder Florence M Schempp Matthew Q Styles Oskar Zelder Source Type: research
Pathologists' perspective on the study design, analysis, and interpretation of proliferative lesions in a lifetime rodent carcinogenicity bioassay of sucralose
Food Chem Toxicol. 2024 Feb 28:114524. doi: 10.1016/j.fct.2024.114524. Online ahead of print.ABSTRACTSucralose, a sugar substitute first approved for use in 1991, is a non-caloric sweetener regulated globally as a food additive. Based on numerous experimental animal studies (dating to the 1980s) and human epidemiology studies, international health agencies have determined that sucralose is safe when consumed as intended. A single lifetime rodent carcinogenicity bioassay conducted by the Ramazzini Institute (RI) reported that mice fed diets containing sucralose develop hematopoietic neoplasia, but controversy continues rega...
Source: Food and Chemical Toxicology - March 1, 2024 Category: Food Science Authors: Susan A Elmore Jerold E Rehg Trenton R Schoeb Jeffrey I Everitt Brad Bolon Source Type: research
Pathologists' perspective on the study design, analysis, and interpretation of proliferative lesions in a lifetime rodent carcinogenicity bioassay of sucralose
Food Chem Toxicol. 2024 Feb 28:114524. doi: 10.1016/j.fct.2024.114524. Online ahead of print.ABSTRACTSucralose, a sugar substitute first approved for use in 1991, is a non-caloric sweetener regulated globally as a food additive. Based on numerous experimental animal studies (dating to the 1980s) and human epidemiology studies, international health agencies have determined that sucralose is safe when consumed as intended. A single lifetime rodent carcinogenicity bioassay conducted by the Ramazzini Institute (RI) reported that mice fed diets containing sucralose develop hematopoietic neoplasia, but controversy continues rega...
Source: Food and Chemical Toxicology - March 1, 2024 Category: Food Science Authors: Susan A Elmore Jerold E Rehg Trenton R Schoeb Jeffrey I Everitt Brad Bolon Source Type: research
< i > Stevia rebaudiana < /i > Bertoni, an American plant used as sweetener: Study of its effects on body mass control and glycemia reduction in Wistar male and female rats
This study ’s objective was to evaluate the effect ofS.rebaudiana leaf extract on Wistar rats as animal model to prove its effectiveness on body mass control, glycemia reduction, and other biochemical parameters. Three groups were randomly formed with 24 males and 24 females: A blank group without any sweetener, a control group drinking water with 10% glucose, and the test group ingesting a 0.94% water extract ofS.rebaudiana. Body mass measurements as well as food and drink consumption were daily performed. The experiment lasted 120 days after the specimens were weaned and got used to eating solid food. Euthanasia was do...
Source: PLoS One - February 27, 2024 Category: Biomedical Science Authors: Samuel Mendoza-P érez Source Type: research
A sustainable strategy for biosynthesis of Rebaudioside D using a novel glycosyltransferase of Solanum tuberosum
Biotechnol J. 2024 Feb;19(2):e2300628. doi: 10.1002/biot.202300628.ABSTRACTBioconversion of Rebaudioside D faces high-cost obstacles. Herein, a novel glycosyltransferase StUGT converting Rebaudioside A to Rebaudioside D was screened and characterized, which exhibits stronger affinity and substrate specificity for Rebaudioside A than previously reported enzymes. A whole-cell catalytic system was thus developed using the StUGT strain. The production of Rebaudioside D was enhanced significantly by enhancing cell permeability, and the maximum production of 6.12 g/L and the highest yield of 98.08% by cell catalyst was obtained ...
Source: Biotechnology Journal - February 25, 2024 Category: Biotechnology Authors: Siyuan Ma Yuanyuan Ma Source Type: research
Decoding the mystery of non-nutritive sweeteners
ConclusionWhile the article underscores the complexities and debates surrounding non-nutritive sweeteners (NNS), it also sheds light on the positive aspects. In the Indian context, where the intake of sweeteners is relatively low and mainly limited to beverages (tea or coffee), NNS appear to be safe, but prudent use is advocated. The article emphasizes the value of public education on NNS usage and concludes that, overall, NNS are reasonably safe when consumed in moderation. Continued research is needed to elucidate their intricate effects on health and impact on global health outcomes.ImplicationsThe article concludes wit...
Source: International Journal of Diabetes in Developing Countries - February 24, 2024 Category: Endocrinology Source Type: research
Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls
ConclusionsAspartame reduces the chance of puberty occurring earlier than usual in female offspring and girls. Particularly, 60 mg kg−1 aspartame-fed female offspring delays pubertal onset through the dysregulation of HPG axis and GM composition by inhibiting the Kiss1/GPR54 system and inducing the RFRP-3. An acceptable dose of aspartame should be recommended during childhood. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - February 23, 2024 Category: Food Science Authors: Chia ‐Yuan Lin,
Nam Nhat Nguyen,
Wan‐Ling Tsai,
Rong‐Hong Hsieh,
Hung‐Tsung Wu,
Yang‐Ching Chen Tags: Research Article Source Type: research
Safety assessment of high fructose corn syrup and fructose used as sweeteners in foods
. (Source: Toxicology Mechanisms and Methods)
Source: Toxicology Mechanisms and Methods - February 23, 2024 Category: Toxicology Authors: Sabire Nur BulbulSevcan MamurDeniz YuzbasiogluFatma Unala Department of Biology, Science Faculty, Gazi University, Ankara, Turkeyb Department of Environmental Sciences, Graduate School of Natural and Applied Sciences, Gazi University, Ankara, Turkey Source Type: research
