Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls
ConclusionsAspartame reduces the chance of puberty occurring earlier than usual in female offspring and girls. Particularly, 60 mg kg−1 aspartame-fed female offspring delays pubertal onset through the dysregulation of HPG axis and GM composition by inhibiting the Kiss1/GPR54 system and inducing the RFRP-3. An acceptable dose of aspartame should be recommended during childhood.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Chia ‐Yuan Lin,
Nam Nhat Nguyen,
Wan‐Ling Tsai,
Rong‐Hong Hsieh,
Hung‐Tsung Wu,
Yang‐Ching Chen Tags: Research Article Source Type: research
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