Aspartame Intake Delayed Puberty Onset in Female Offspring Rats and Girls

ConclusionsAspartame reduces the chance of puberty occurring earlier than usual in female offspring and girls. Particularly, 60  mg kg−1 aspartame-fed female offspring delays pubertal onset through the dysregulation of HPG axis and GM composition by inhibiting the Kiss1/GPR54 system and inducing the RFRP-3. An acceptable dose of aspartame should be recommended during childhood.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research