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Evolution of household availability of added sugars and their sources in Brazil: analysis of Household Budget Surveys from 2002 to 2017
In conclusion, Brazilians' total intake of added sugar was decreased, mostly owing to reduced consumption of sugar from soft drinks.PMID:38634261 | DOI:10.1017/S0007114524000813 (Source: The British Journal of Nutrition)
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Daniela Silva Canella Maria Laura da Costa Louzada Nat ália Oliveira Ana Beatriz Coelho de Azevedo Renata Bertazzi Levy Source Type: research

The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: American Journal of Veterinary Research - April 16, 2024 Category: Veterinary Research Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research

The pharmacokinetics of single-dose oral atorvastatin and its metabolites support therapeutic use in cockatiels (Nymphicus hollandicus)
Am J Vet Res. 2024 Apr 19:1-7. doi: 10.2460/ajvr.24.03.0068. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the plasma concentrations and determine the pharmacokinetic parameters of atorvastatin and its primary active metabolites (para- and orthohydroxyatorvastatin) after administration of a single oral dose in cockatiels (Nymphicus hollandicus).ANIMALS: 14 adult cockatiels (7 male, 7 female) around 2 years of age.METHODS: A compounded oral suspension of atorvastatin 10 mg/mL made with an oral suspending agent and an oral sweetener was administered via oral gavage at 20 mg/kg to each bird. Blood samples were collecte...
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Michaela Mitchell David Sanchez-Migallon Guzman Heather Knych Hugues Beaufr ère Source Type: research

Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research

Interaction between diet and genetics in patients with inflammatory bowel disease
In conclusion, IBD is a complex and heterogeneous disease, and future studies are needed to elucidate the influence of epigenetics on diet and microbiota in IBD patients.PMID:38617734 | PMC:PMC11008370 | DOI:10.3748/wjg.v30.i12.1644 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Dani éla Oliveira Magro Ligia Yukie Sassaki J úlio Maria Fonseca Chebli Source Type: research

Molecules, Vol. 29, Pages 1771: Synthesis of Sucrose-Mimicking Disaccharide by Intramolecular Aglycone Delivery
Yoichi Takeda Rare sugars are known for their ability to suppress postprandial blood glucose levels. Therefore, oligosaccharides and disaccharides derived from rare sugars could potentially serve as functional sweeteners. A disaccharide [&alpha;-d-allopyranosyl-(1&rarr;2)-&beta;-d-psicofuranoside] mimicking sucrose was synthesized from rare monosaccharides D-allose and D-psicose. Glycosylation using the intermolecular aglycon delivery (IAD) method was employed to selectively form 1,2-cis &alpha;-glycosidic linkages of the allopyranose residues. Moreover, &beta;-selective psicofur...
Source: Molecules - April 13, 2024 Category: Chemistry Authors: Kanae Sano Akihiro Ishiwata Hiroto Takamori Takashi Kikuma Katsunori Tanaka Yukishige Ito Yoichi Takeda Tags: Article Source Type: research

Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation
Biochem Biophys Res Commun. 2024 Apr 9;711:149921. doi: 10.1016/j.bbrc.2024.149921. Online ahead of print.ABSTRACTArtificial sweeteners, which contain no or few calories, have been widely used in various foods and beverages, and are regarded as safe alternatives to sugar by the Food and Drug Administration. While several studies suggest that artificial sweeteners are not related to cancer development, some research has reported their potential association with the risk of cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether acesulfame potassium (Ace K), a commonly used artificial sweetener, indu...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Dong-Ho Kim Eun-Jun Kwon Keun-Gyu Park Jonghwa Jin Jun-Kyu Byun Source Type: research

Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation
Biochem Biophys Res Commun. 2024 Apr 9;711:149921. doi: 10.1016/j.bbrc.2024.149921. Online ahead of print.ABSTRACTArtificial sweeteners, which contain no or few calories, have been widely used in various foods and beverages, and are regarded as safe alternatives to sugar by the Food and Drug Administration. While several studies suggest that artificial sweeteners are not related to cancer development, some research has reported their potential association with the risk of cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether acesulfame potassium (Ace K), a commonly used artificial sweetener, indu...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Dong-Ho Kim Eun-Jun Kwon Keun-Gyu Park Jonghwa Jin Jun-Kyu Byun Source Type: research