Reactive Oxygen Species ‐Responsive Composite Fibers Regulate Oxidative Metabolism through Internal and External Factors to Promote the Recovery of Nerve Function
Inspired by the pathological characteristics of excess ROS and depletion of neurotrophins after spinal cord injury, a composite fiber scaffold with spatiotemporal delivery for the efficient regulation of ROS and continuous supply of neurotrophins is developed in the study. The biomimetic composite fiber scaffold can promote the cascade reaction of neuronal autophagy metabolism, improve the local microenvironment, and help reconstruct neural networks. AbstractIt is challenging to sufficiently regulate endogenous neuronal reactive oxygen species (ROS) production, reduce neuronal apoptosis, and reconstruct neural networks und...
Source: Small - April 25, 2024 Category: Nanotechnology Authors: Hongyi Zhu,
Liang Zhou,
Jincheng Tang,
Yichang Xu,
Wei Wang,
Wenxiao Shi,
Ziang Li,
Lichen Zhang,
Zhouye Ding,
Kun Xi,
Yong Gu,
Liang Chen Tags: Research Article Source Type: research
Development and validation of a risk nomogram to estimate risk of hyponatremia after spinal cord injury: A retrospective single-center study
CONCLUSIONS: Nomogram has good predictive ability, sex, completeness of SCI, pneumonia, urinary tract infection, fever, constipation, WBC, albumin and serum Ca2+ were predictors of hyponatremia after SCI.PMID:38656250 | DOI:10.1080/10790268.2024.2329437 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 24, 2024 Category: Orthopaedics Authors: Qian Wei Xuefeng Lu Zihong Yang Jichong Zhu Jie Jiang Yaobin Xu Fengxin Li Haifeng Bu Yikai Chen Sijing Tuo Ruyu Chen Xiaoxia Ye Laoyi Geer Xiuwei Tan Jiling Wang Yanlan Wu Fangming Song Yiji Su Source Type: research
Conditioned medium-enriched umbilical cord mesenchymal stem cells: a potential therapeutic strategy for spinal cord injury, unveiling transcriptomic and secretomic insights
CONCLUSIONS: In conclusion, the CBG-UCNSC method effectively preserved the integrity of the transplanted neuronal-like cells and improved locomotor function. Thus, CM-enriched cells can potentially reduce biosafety risks associated with animal content, making them a promising option for clinical applications in treating spinal cord injuries.PMID:38658405 | DOI:10.1007/s11033-024-09503-8 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 24, 2024 Category: Molecular Biology Authors: Rajasekaran Subbarayan Dinesh Murugan Girija Selvaraj Thirupathi Kumara Raja Alagudurai Krishnamoorthy Dhasarathdev Srinivasan Rupendra Shrestha Nityanand Srivastava Suresh Ranga Rao Source Type: research
Conditioned medium-enriched umbilical cord mesenchymal stem cells: a potential therapeutic strategy for spinal cord injury, unveiling transcriptomic and secretomic insights
CONCLUSIONS: In conclusion, the CBG-UCNSC method effectively preserved the integrity of the transplanted neuronal-like cells and improved locomotor function. Thus, CM-enriched cells can potentially reduce biosafety risks associated with animal content, making them a promising option for clinical applications in treating spinal cord injuries.PMID:38658405 | DOI:10.1007/s11033-024-09503-8 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 24, 2024 Category: Molecular Biology Authors: Rajasekaran Subbarayan Dinesh Murugan Girija Selvaraj Thirupathi Kumara Raja Alagudurai Krishnamoorthy Dhasarathdev Srinivasan Rupendra Shrestha Nityanand Srivastava Suresh Ranga Rao Source Type: research
Development and validation of a risk nomogram to estimate risk of hyponatremia after spinal cord injury: A retrospective single-center study
CONCLUSIONS: Nomogram has good predictive ability, sex, completeness of SCI, pneumonia, urinary tract infection, fever, constipation, WBC, albumin and serum Ca2+ were predictors of hyponatremia after SCI.PMID:38656250 | DOI:10.1080/10790268.2024.2329437 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 24, 2024 Category: Orthopaedics Authors: Qian Wei Xuefeng Lu Zihong Yang Jichong Zhu Jie Jiang Yaobin Xu Fengxin Li Haifeng Bu Yikai Chen Sijing Tuo Ruyu Chen Xiaoxia Ye Laoyi Geer Xiuwei Tan Jiling Wang Yanlan Wu Fangming Song Yiji Su Source Type: research
TP53INP2 knockdown inhibits inflammatory response and apoptosis after spinal cord injury
ConclusionsAfter spinal cord injury, TP53INP2 was upregulated, and TP53INP2 knockdown inhibited the inflammatory response and apoptosis. (Source: Immunity, Inflammation and Disease)
Source: Immunity, Inflammation and Disease - April 23, 2024 Category: Allergy & Immunology Authors: Penghao Sun,
Jinchuan Chen,
Rujie Qin Tags: ORIGINAL ARTICLE Source Type: research
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis
This study aimed to explore the hub genes and related key pathways in Spinal Cord Injury (SCI) based on the bioinformatics analysis. Two microarray datasets (GSE45006, GSE45550) were obtained from the GEO database and were merged and batch-corrected. The differentially expressed genes (DEGs) in SCI were explored with the Limma, and the weighted gene co-expression network analysis (WGCNA) was conducted to explore the module genes. Functional enrichment analysis and Gene set variation analysis (GSVA) were used to investigate the biological functions and key pathways of the key genes related to SCI. Then the protein-protein i...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Hao Cheng Yanben Wang Jun Xuan Source Type: research
Small nucleolar RNA host gene 1 silence inhibits the lipopolysaccharide-induced microglial apoptosis and inflammation
This study was designed to investigate the role of small nucleolar RNA host gene 1 (SNHG1) on the apoptosis and inflammatory response of microglial cell BV-2 and its underlying molecular mechanism. The C5 lamina contusion-induced mouse model of spinal cord injury (SCI) was constructed. Mouse microglia BV2 was stimulated by lipopolysaccharide (LPS) to establish the in vitro model of SCI. The quantitative reverse transcription polymerase chain reaction method was used to quantify RNA expression levels. Enzyme-linked immunosorbent assays were used to quantify concentrations of inflammatory cytokines. Protein levels were asses...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Hongtao Shen Jiaao Gu Xing Liu Mowei Song Source Type: research
"Pressure kills kidneys": protection of the upper urinary tract through neuro-urological management
This article is intended to provide information about the epidemiology and complex pathogenetic mechanisms as well as the necessary diagnostic steps. Various medical, interventional and surgical treatment strategies are evaluated on the basis of current scientific findings, thus supporting the reader in the care of this complex patient group.PMID:38653468 | DOI:10.1055/a-2287-4933 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - April 23, 2024 Category: Urology & Nephrology Authors: Fabian Quei ßert Andres Jan Schrader Source Type: research
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis
This study aimed to explore the hub genes and related key pathways in Spinal Cord Injury (SCI) based on the bioinformatics analysis. Two microarray datasets (GSE45006, GSE45550) were obtained from the GEO database and were merged and batch-corrected. The differentially expressed genes (DEGs) in SCI were explored with the Limma, and the weighted gene co-expression network analysis (WGCNA) was conducted to explore the module genes. Functional enrichment analysis and Gene set variation analysis (GSVA) were used to investigate the biological functions and key pathways of the key genes related to SCI. Then the protein-protein i...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Hao Cheng Yanben Wang Jun Xuan Source Type: research
Small nucleolar RNA host gene 1 silence inhibits the lipopolysaccharide-induced microglial apoptosis and inflammation
This study was designed to investigate the role of small nucleolar RNA host gene 1 (SNHG1) on the apoptosis and inflammatory response of microglial cell BV-2 and its underlying molecular mechanism. The C5 lamina contusion-induced mouse model of spinal cord injury (SCI) was constructed. Mouse microglia BV2 was stimulated by lipopolysaccharide (LPS) to establish the in vitro model of SCI. The quantitative reverse transcription polymerase chain reaction method was used to quantify RNA expression levels. Enzyme-linked immunosorbent assays were used to quantify concentrations of inflammatory cytokines. Protein levels were asses...
Source: Mol Biol Cell - April 23, 2024 Category: Molecular Biology Authors: Hongtao Shen Jiaao Gu Xing Liu Mowei Song Source Type: research
A systematic review of validity and reliability assessment of measuring balance and walking at the level of International Classification of Functioning, Disability and Health (ICF) in people with spinal cord injury
CONCLUSIONS: One consideration for testing people with disabilities is to observe the reliability and validity of the instrument, which was addressed in this study in various fields. In our study, seven tools for assessing SCI were evaluated, and it was found that the 10-meter walk (10MWT) tool performs better and more easily than other tools. The Mini-BESTest tool was suggested as a reliable tool for assessing standing balance in SCI subjects.PMID:38652087 | DOI:10.1080/10790268.2024.2335413 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 23, 2024 Category: Orthopaedics Authors: Zahra Hosseinzadeh Mohammad Karimizadeh Ardakani Hooman Minoonejad Source Type: research
Identification of hub genes and key pathways in spinal cord injury via bioinformatics analysis
This study aimed to explore the hub genes and related key pathways in Spinal Cord Injury (SCI) based on the bioinformatics analysis. Two microarray datasets (GSE45006, GSE45550) were obtained from the GEO database and were merged and batch-corrected. The differentially expressed genes (DEGs) in SCI were explored with the Limma, and the weighted gene co-expression network analysis (WGCNA) was conducted to explore the module genes. Functional enrichment analysis and Gene set variation analysis (GSVA) were used to investigate the biological functions and key pathways of the key genes related to SCI. Then the protein-protein i...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Hao Cheng Yanben Wang Jun Xuan Source Type: research
Small nucleolar RNA host gene 1 silence inhibits the lipopolysaccharide-induced microglial apoptosis and inflammation
This study was designed to investigate the role of small nucleolar RNA host gene 1 (SNHG1) on the apoptosis and inflammatory response of microglial cell BV-2 and its underlying molecular mechanism. The C5 lamina contusion-induced mouse model of spinal cord injury (SCI) was constructed. Mouse microglia BV2 was stimulated by lipopolysaccharide (LPS) to establish the in vitro model of SCI. The quantitative reverse transcription polymerase chain reaction method was used to quantify RNA expression levels. Enzyme-linked immunosorbent assays were used to quantify concentrations of inflammatory cytokines. Protein levels were asses...
Source: Cellular and Molecular Biology - April 23, 2024 Category: Molecular Biology Authors: Hongtao Shen Jiaao Gu Xing Liu Mowei Song Source Type: research
"Pressure kills kidneys": protection of the upper urinary tract through neuro-urological management
This article is intended to provide information about the epidemiology and complex pathogenetic mechanisms as well as the necessary diagnostic steps. Various medical, interventional and surgical treatment strategies are evaluated on the basis of current scientific findings, thus supporting the reader in the care of this complex patient group.PMID:38653468 | DOI:10.1055/a-2287-4933 (Source: Aktuelle Urologie)
Source: Aktuelle Urologie - April 23, 2024 Category: Urology & Nephrology Authors: Fabian Quei ßert Andres Jan Schrader Source Type: research
