Wallerian Degeneration Assessed by Multi-Modal Magnetic Resonance Imaging of Cervical Spinal Cord Is Associated With Neurological Impairment After Spinal Cord Injury
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 15, 2024 Category: Neurology Authors: Haiyang Yu Zhenzhen Liu Mao Pang Qiuxia Luo Chong Huang Weijie He Bin Liu Limin Rong Source Type: research
Systematic Review and Meta-Analysis of Cerebro-Spinal Fluid Drain-Related Mortality and Morbidity After Fenestrated-Branched Endovascular Aortic Repair
This study aimed to investigate the incidence of cerebrospinal fluid drainage (CSFD)-related complications specifically in patients undergoing fenestrated and branched endovascular aortic repair (F/B-EVAR). This objective was chosen considering the limitations and uncertainties surrounding its efficacy in preventing spinal cord injury (SCI). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 15, 2024 Category: Surgery Authors: Nicola Leone, Mario D ’Oria, Kevin Mani, Gustavo Oderich, Gianmarco Maleti, Luigi AM. Bartolotti, Roberto Silingardi, Sandro Lepidi, Stefano Gennai Source Type: research
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation
In this study, we composited an innovative MG53/GMs/HA-Dex neural scaffold using gelatin microspheres (GMs), hyaluronic acid (HA), and dextran (Dex) loaded with MG53 protein. This novel neural scaffold could respond to MMP-2/9 protein and stably release MG53 protein with good physicochemical properties and biocompatibility. In addition, it significantly improved the motor function of SCI mice, suppressed M1 polarization of microglia and neuroinflammation, and promoted neurogenesis and axon regeneration. Further mechanistic experiments demonstrated that MG53/GMs/HA-Dex hydrogel inhibited the JAK2/STAT3 signaling pathway. Th...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Xingfan Li Rong Ji Linyan Duan Zhizhong Hao Yujing Su Hao Wang Fangxia Guan Shanshan Ma Source Type: research
Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation
Neurobiol Dis. 2024 Apr 11:106500. doi: 10.1016/j.nbd.2024.106500. Online ahead of print.ABSTRACTSpinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical orga...
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Maria M Moura Andreia Monteiro Ant ónio J Salgado Nuno A Silva Susana Monteiro Source Type: research
Combining Fecal 16S rRNA Sequencing and Spinal Cord Metabolomics analysis to explain the modulatory effect of PPAR α on Neuropathic Pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
Combining Fecal 16S rRNA Sequencing and Spinal Cord Metabolomics analysis to explain the modulatory effect of PPAR α on Neuropathic Pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research)
Source: Brain Research - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
Combining fecal 16 S rRNA sequencing and spinal cord metabolomics analysis to explain the modulatory effect of PPARα on neuropathic pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
Combining fecal 16 S rRNA sequencing and spinal cord metabolomics analysis to explain the modulatory effect of PPARα on neuropathic pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research)
Source: Brain Research - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation
Neurobiol Dis. 2024 Apr 11:106500. doi: 10.1016/j.nbd.2024.106500. Online ahead of print.ABSTRACTSpinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical orga...
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Maria M Moura Andreia Monteiro Ant ónio J Salgado Nuno A Silva Susana Monteiro Source Type: research
Influence of Local Vibration Therapy on the Mental State, Neurological Function, and Quality of Life of Convalescing Patients With Spinal Cord Injury
CONCLUSION: Local vibration therapy combined with self-efficacy training positively influenced the rapid recovery of neurological function and daily-living ability postoperatively for SCI patients. It also effectively improved patients' psychological states and overall QoL. These findings suggest the potential for further clinical use. Additionally, the close relationship between neurological function, psychological state, and QoL underscores the importance of incorporating interventions that target these areas in clinical nursing management for SCI patients.PMID:38607194 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Xiaoqian Zheng Lei Wang Liping Meng Zhenzhen Xu Source Type: research
Integrating Patient Preferences with Guideline-Based Care in Neurogenic Lower Urinary Tract Dysfunction After Spinal Cord Injury
Urol Clin North Am. 2024 May;51(2):277-284. doi: 10.1016/j.ucl.2024.02.002. Epub 2024 Mar 7.ABSTRACTIndividual and social factors are important for clinical decision-making in patients with neurogenic bladder secondary to spinal cord injury (SCI). These factors include the availability of caregivers, social infrastructure, and personal preferences, which all can drive bladder management decisions. These elements can be overlooked in clinical decision-making; therefore, there is a need to elicit and prioritize patient preferences and values into neurogenic bladder care to facilitate personalized bladder management choices. ...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Vivian Wong Giulia M Ippolito Irene Crescenze Source Type: research
Bladder-Related Quality of Life After Spinal Cord Injury: Findings from the Neurogenic Bladder Research Group Spinal Cord Injury Registry
Urol Clin North Am. 2024 May;51(2):163-176. doi: 10.1016/j.ucl.2024.02.004. Epub 2024 Mar 11.ABSTRACTThe Neurogenic Bladder Research Group (NBRG) was formed with the mission to optimize quality of life (QoL), surgical outcomes, and clinical care of patients with neurogenic lower urinary tract dysfunction. One of the original priorities of the organization was to support creation of the NBRG Spinal Cord Injury (SCI) Registry. The aim of this Registry was to establish a prospective database, in order to study bladder-related QoL after SCI. The study enrolled close to 1500 participants from across North America over an 18 mon...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Jeremy B Myers Jane T Kurtzman Source Type: research
Influence of Local Vibration Therapy on the Mental State, Neurological Function, and Quality of Life of Convalescing Patients With Spinal Cord Injury
CONCLUSION: Local vibration therapy combined with self-efficacy training positively influenced the rapid recovery of neurological function and daily-living ability postoperatively for SCI patients. It also effectively improved patients' psychological states and overall QoL. These findings suggest the potential for further clinical use. Additionally, the close relationship between neurological function, psychological state, and QoL underscores the importance of incorporating interventions that target these areas in clinical nursing management for SCI patients.PMID:38607194 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Xiaoqian Zheng Lei Wang Liping Meng Zhenzhen Xu Source Type: research
Integrating Patient Preferences with Guideline-Based Care in Neurogenic Lower Urinary Tract Dysfunction After Spinal Cord Injury
Urol Clin North Am. 2024 May;51(2):277-284. doi: 10.1016/j.ucl.2024.02.002. Epub 2024 Mar 7.ABSTRACTIndividual and social factors are important for clinical decision-making in patients with neurogenic bladder secondary to spinal cord injury (SCI). These factors include the availability of caregivers, social infrastructure, and personal preferences, which all can drive bladder management decisions. These elements can be overlooked in clinical decision-making; therefore, there is a need to elicit and prioritize patient preferences and values into neurogenic bladder care to facilitate personalized bladder management choices. ...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Vivian Wong Giulia M Ippolito Irene Crescenze Source Type: research
Bladder-Related Quality of Life After Spinal Cord Injury: Findings from the Neurogenic Bladder Research Group Spinal Cord Injury Registry
Urol Clin North Am. 2024 May;51(2):163-176. doi: 10.1016/j.ucl.2024.02.004. Epub 2024 Mar 11.ABSTRACTThe Neurogenic Bladder Research Group (NBRG) was formed with the mission to optimize quality of life (QoL), surgical outcomes, and clinical care of patients with neurogenic lower urinary tract dysfunction. One of the original priorities of the organization was to support creation of the NBRG Spinal Cord Injury (SCI) Registry. The aim of this Registry was to establish a prospective database, in order to study bladder-related QoL after SCI. The study enrolled close to 1500 participants from across North America over an 18 mon...
Source: The Urologic Clinics of North America - April 12, 2024 Category: Urology & Nephrology Authors: Jeremy B Myers Jane T Kurtzman Source Type: research
