Autonomic impairment is not explained by neurological level of injury or motor-sensory completeness
Spinal Cord, Published online: 12 April 2024; doi:10.1038/s41393-024-00994-7Autonomic impairment is not explained by neurological level of injury or motor-sensory completeness (Source: Spinal Cord)
Source: Spinal Cord - April 12, 2024 Category: Research Authors: Kathryn Burns Ryan Solinsky Source Type: research
The role of clinical and demographic predictors for understanding the cognitive impairment in Spinal Cord Injury (SCI) patients
Spinal Cord, Published online: 12 April 2024; doi:10.1038/s41393-024-00986-7The role of clinical and demographic predictors for understanding the cognitive impairment in Spinal Cord Injury (SCI) patients (Source: Spinal Cord)
Source: Spinal Cord - April 12, 2024 Category: Research Authors: Ana Clara Portela Hara Nicole C. Aching Lucas M. Marques Sara P. Barbosa Daniel R. Souza Felipe Fregni Linamara R. Battistella Marcel Simis Source Type: research
Implicit and explicit motor imagery ability after SCI: Moving the elbow makes the difference
Brain Res. 2024 Apr 9:148911. doi: 10.1016/j.brainres.2024.148911. Online ahead of print.ABSTRACTCervical spinal cord injury (SCI) causes dramatic sensorimotor deficits that restrict both activity and participation. Restoring activity and participation requires extensive upper limb rehabilitation focusing elbow and wrist movements, which can include motor imagery. Yet, it remains unclear whether MI ability is impaired or spared after SCI. We investigated implicit and explicit MI ability in individuals with C6 or C7 SCI (SCIC6 and SCIC7 groups), as well as in aged- and gender-matched controls without SCI. Inspired by previo...
Source: Brain Research - April 11, 2024 Category: Neurology Authors: S ébastien Mateo Aymeric Guillot Sonia Henkous Anthony Gelis S ébastien Daligault Gilles Rode Christian Collet Franck Di Rienzo Source Type: research
Implicit and explicit motor imagery ability after SCI: Moving the elbow makes the difference
Brain Res. 2024 Apr 9:148911. doi: 10.1016/j.brainres.2024.148911. Online ahead of print.ABSTRACTCervical spinal cord injury (SCI) causes dramatic sensorimotor deficits that restrict both activity and participation. Restoring activity and participation requires extensive upper limb rehabilitation focusing elbow and wrist movements, which can include motor imagery. Yet, it remains unclear whether MI ability is impaired or spared after SCI. We investigated implicit and explicit MI ability in individuals with C6 or C7 SCI (SCIC6 and SCIC7 groups), as well as in aged- and gender-matched controls without SCI. Inspired by previo...
Source: Brain Research - April 11, 2024 Category: Neurology Authors: S ébastien Mateo Aymeric Guillot Sonia Henkous Anthony Gelis S ébastien Daligault Gilles Rode Christian Collet Franck Di Rienzo Source Type: research
The Neurourology Journey: From Pads to Jack Lapides and Intermittent Catheterization to Multidisciplinary Management
This issue of Urologic Clinics of North America, edited by John T. Stoffel, represents the culmination of centuries of study of voiding dysfunction —its causes and treatments. Descriptions of urinary incontinence from spinal cord injury can be found as early as the second millennium bc in Egyptian manuscripts.1,2 Claudius Galen (129–201 ad) is credited as being the first to perform physiologic experiments on the lower-urinary tract, and he concluded that micturition is achieved by contraction of the abdominal muscles. (Source: Urologic Clinics of North America)
Source: Urologic Clinics of North America - April 11, 2024 Category: Urology & Nephrology Authors: Kevin R. Loughlin Tags: Foreword Source Type: research
Beyond expectations: safinamide ’s unprecedented neuroprotective impact on acute spinal cord injury
ConclusionThis study revealed that safinamide has neuroprotective effects against SCI due to its anti-inflammatory, antiapoptotic, and antioxidant activities. (Source: European Journal of Trauma and Emergency Surgery)
Source: European Journal of Trauma and Emergency Surgery - April 11, 2024 Category: Emergency Medicine Source Type: research
Advanced Magnetic Resonance Imaging Biomarkers of the Injured Spinal Cord: A Comparative Study of Imaging and Histology in Human Traumatic Spinal Cord Injury
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 11, 2024 Category: Neurology Authors: Sarah Morris Taylor Swift-LaPointe Andrew Yung Valentin Prevost Shana George Andrew Bauman Piotr Kozlowski Zahra Samadi-Bahrami Caron Fournier Pushwant Singh Mattu Lisa Parker Femke Streijger Veronica Hirsch-Reinshagen G.R. Wayne Moore Brian K. Kwon Corne Source Type: research
Mirror-Image Pain Update: Complex Interactions Between Central and Peripheral Mechanisms
AbstractThe appearance of contralateral effects after unilateral injury has been shown in various experimental pain models, as well as in clinics. They consist of a diversity of phenomena in contralateral peripheral nerves, sensory ganglia, or spinal cord: from structural changes and altered gene or protein expression to functional consequences such as the development of mirror-image pain (MP). Although MP is a well-documented phenomenon, the exact molecular mechanism underlying the induction and maintenance of mirror-like spread of pain is still an unresolved challenge. MP has generally been explained by central sensitiza...
Source: Molecular Neurobiology - April 11, 2024 Category: Neurology Source Type: research
Screening biomarkers for spinal cord injury using weighted gene co-expression network analysis and machine learning
In this study, we obtained microRNA expression profiles from the peripheral blood of patients with spinal cord injury using high-throughput sequencing. We also obtained the mRNA expression profile of spinal cord injury patients from the Gene Expression Omnibus (GEO) database (GSE151371). We identified 54 differentially expressed microRNAs and 1656 differentially expressed genes using bioinformatics approaches. Functional enrichment analysis revealed that various common immune and inflammation-related signaling pathways, such as neutrophil extracellular trap formation pathway, T cell receptor signaling pathway, and nuclear ...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Xiaolu Li Ye Yang Senming Xu Yuchang Gui Jianmin Chen Jianwen Xu Source Type: research
Neurogenic potential of NG2 in neurotrauma: a systematic review
Neural Regen Res. 2024 Dec 1;19(12):2673-2683. doi: 10.4103/NRR.NRR-D-23-01031. Epub 2024 Mar 1.ABSTRACTRegenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of research. This is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic targets in spinal cord and traumatic brain injuries. Significant advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma research. R...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Yuri R Rigo Radharani Benvenutti Luis V Portela Nathan R Strogulski Source Type: research
Oncological relevance of neuro-urological diseases
Aktuelle Urol. 2024 Apr 10. doi: 10.1055/a-2269-1222. Online ahead of print.ABSTRACTApart from a few exceptions, there is currently little scientific evidence on the oncological relevance of neuro-urological diseases. Most research has been conducted into the association between long-term spinal cord injury with its consequences for the lower urinary tract and the occurrence of bladder cancer. These cancers differ in many ways from bladder cancers in patients without spinal cord injury: patients are 20 years younger on average, tumours are very often already muscle-invasive and poorly differentiated with a high proportion ...
Source: Aktuelle Urologie - April 10, 2024 Category: Urology & Nephrology Authors: Ralf B öthig Wolfgang Sch öps Birgitt Kowald Klaus Golka Source Type: research
Oncological relevance of neuro-urological diseases
Aktuelle Urol. 2024 Apr 10. doi: 10.1055/a-2269-1222. Online ahead of print.ABSTRACTApart from a few exceptions, there is currently little scientific evidence on the oncological relevance of neuro-urological diseases. Most research has been conducted into the association between long-term spinal cord injury with its consequences for the lower urinary tract and the occurrence of bladder cancer. These cancers differ in many ways from bladder cancers in patients without spinal cord injury: patients are 20 years younger on average, tumours are very often already muscle-invasive and poorly differentiated with a high proportion ...
Source: Aktuelle Urologie - April 10, 2024 Category: Urology & Nephrology Authors: Ralf B öthig Wolfgang Sch öps Birgitt Kowald Klaus Golka Source Type: research
Fascin-1 limits myosin activity in microglia to control mechanical characterization of the injured spinal cord
Mechanical softening of the glial scar region regulates axonal regeneration to impede neurological recovery in central nervous system (CNS) injury. Microglia, a crucial cellular component of the glial scar, fa... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - April 10, 2024 Category: Neurology Authors: Jinxin Huang, Xuyang Hu, Zeqiang Chen, Fangru Ouyang, Jianjian Li, Yixue Hu, Yuanzhe Zhao, Jingwen Wang, Fei Yao, Juehua Jing and Li Cheng Tags: Research Source Type: research
Response to the letter to editor regarding “Effects of Anodal Transcranial Direct Current Stimulation with Overground Gait Training on Lower Limb Performance in Individuals with Incomplete Spinal Cord Injury”
We thank the authors for providing suggestions to our recent manuscript: Effects of Anodal Transcranial Direct Current Stimulation with Overground Gait Training on Lower Limb Performance in Individuals with Incomplete Spinal Cord Injury. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - April 10, 2024 Category: Rehabilitation Authors: Pipat Klamruen, Jatuporn Suttiwong, Benchaporn Aneksan, Monticha Muangngoen, Chanapass Denduang, Wanalee Klomjai Source Type: research
Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 10, 2024 Category: Neurology Authors: Kevin M. Koch Andrew S. Nencka Shekar Kurpad Matthew D. Budde Source Type: research
