Providing Gender-Affirming Care for a Veteran with a New Spinal Cord Injury
1. Review unique clinical and pharmacological considerations in the intersection of gender affirming care, geriatric medicine and spinal cord injury.2. Explore potential nuances and complexities of advance care planning and shared decision making in the transgender geriatric population. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Jennifer Turpen, Katherine Recka Source Type: research
The synergistic potential of hydrogen inhalation and hyperbaric oxygen therapy
We read with great interest the review by Lee and colleagues, in which the authors describe the use of hyperbaric oxygen therapy (HBOT) as a novel adjunctive treatment to standard treatment for spinal cord injury (SCI) after complex aortic repair (CAR).1 HBOT is a revolutionary therapy for many postsurgical complications such as SCI after CAR. We are curious to know if the authors considered hydrogen inhalation therapy (HIT) in combination with HBOT. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 18, 2024 Category: Surgery Authors: Michael G. James, Viren S. Sehgal Tags: Letter to the Editor Source Type: research
Onabotulinum toxin A improves neurogenic detrusor overactivity following spinal cord injury: a systematic review and meta-analysis
Spinal Cord, Published online: 18 April 2024; doi:10.1038/s41393-024-00992-9Onabotulinum toxin A improves neurogenic detrusor overactivity following spinal cord injury: a systematic review and meta-analysis (Source: Spinal Cord)
Source: Spinal Cord - April 18, 2024 Category: Research Authors: Saeed Vaheb Yousef Mokary Hamed Ghoshouni Omid Mirmosayyeb Elham Moases Ghaffary Vahid Shaygannejad Mohammad Yazdan Panah Source Type: research
Cardiorespiratory Responses to Acute Intermittent Hypoxia in Humans With Chronic Spinal Cord Injury
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 18, 2024 Category: Neurology Authors: Joseph F. Welch Alicia K. Vose Kate Cavka Gina Brunetti Louis A. DeMark Hannah Snyder Clayton N. Wauneka Geneva Tonuzi Jayakrishnan Nair Gordon S. Mitchell Emily J. Fox Source Type: research
Elevated microRNA-214-3p level ameliorates neuroinflammation after spinal cord ischemia-reperfusion injury by inhibiting Nmb/Cav3.2 pathway
CONCLUSIONS: Nmb protein levels positively correlated with Cav3.2 expression in SCII rats. Upregulating miR-214-3p ameliorated hind-limb motor function and protected against neuroinflammation via inhibiting the aberrant Nmb/Cav3.2 interactions and downstream IL-1β release. These findings provide novel therapeutic targets for clinical prevention and treatment of SCII.PMID:38631219 | DOI:10.1016/j.intimp.2024.112031 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Guo-Qiang Xia Miao Xu Cong Sun Zai-Li Zhang Xiao-Qian Li Source Type: research
Invasive neurostimulation in neuro-urology: state of the art
Aktuelle Urol. 2024 Apr 17. doi: 10.1055/a-2261-4792. Online ahead of print.ABSTRACTModulation or stimulation of the nerves supplying the lower urinary tract is a possible treatment option for dysfunction of the lower urinary tract, pelvic floor and rectum if conservative or minimally invasive treatment approaches fail. This overview shows the possibilities and limitations of sacral neuromodulation, sacral deafferentation with sacral anterior root stimulation and conus deafferentation.Sacral neuromodulation (SNM) is a procedure for the treatment of refractory pelvic floor dysfunction of various origins (idiopathic, neuroge...
Source: Aktuelle Urologie - April 17, 2024 Category: Urology & Nephrology Authors: Ines Kurze Ralf B öthig Arndt van Ophoven Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
An improved method for generating human spinal cord neural stem cells
Exp Neurol. 2024 Apr 13:114779. doi: 10.1016/j.expneurol.2024.114779. Online ahead of print.ABSTRACTNeural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently reported that neural stem cells must be driven to a spinal cord fate to optimize host axonal regeneration into sites of implantation in the injured spinal cord, where they subsequently form neural relays across the lesion that support significant functional improvement. We also reported methods of deriving and culturing human spinal cord neural stem cells derived from embr...
Source: Experimental Neurology - April 15, 2024 Category: Neurology Authors: Y Li H Kumamaru T Vokes A Tran C Shevinsky L Graham K Archuleta K Limon P Lu A Blesch M H Tuszynski J H Brock Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
Wallerian Degeneration Assessed by Multi-Modal Magnetic Resonance Imaging of Cervical Spinal Cord Is Associated With Neurological Impairment After Spinal Cord Injury
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 15, 2024 Category: Neurology Authors: Haiyang Yu Zhenzhen Liu Mao Pang Qiuxia Luo Chong Huang Weijie He Bin Liu Limin Rong Source Type: research
Systematic Review and Meta-Analysis of Cerebro-Spinal Fluid Drain-Related Mortality and Morbidity After Fenestrated-Branched Endovascular Aortic Repair
This study aimed to investigate the incidence of cerebrospinal fluid drainage (CSFD)-related complications specifically in patients undergoing fenestrated and branched endovascular aortic repair (F/B-EVAR). This objective was chosen considering the limitations and uncertainties surrounding its efficacy in preventing spinal cord injury (SCI). (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 15, 2024 Category: Surgery Authors: Nicola Leone, Mario D ’Oria, Kevin Mani, Gustavo Oderich, Gianmarco Maleti, Luigi AM. Bartolotti, Roberto Silingardi, Sandro Lepidi, Stefano Gennai Source Type: research
MG53/GMs/HA-Dex neural scaffold promotes the functional recovery of spinal cord injury by alleviating neuroinflammation
In this study, we composited an innovative MG53/GMs/HA-Dex neural scaffold using gelatin microspheres (GMs), hyaluronic acid (HA), and dextran (Dex) loaded with MG53 protein. This novel neural scaffold could respond to MMP-2/9 protein and stably release MG53 protein with good physicochemical properties and biocompatibility. In addition, it significantly improved the motor function of SCI mice, suppressed M1 polarization of microglia and neuroinflammation, and promoted neurogenesis and axon regeneration. Further mechanistic experiments demonstrated that MG53/GMs/HA-Dex hydrogel inhibited the JAK2/STAT3 signaling pathway. Th...
Source: International Journal of Biological Macromolecules - April 14, 2024 Category: Biochemistry Authors: Xingfan Li Rong Ji Linyan Duan Zhizhong Hao Yujing Su Hao Wang Fangxia Guan Shanshan Ma Source Type: research
Disrupted autonomic pathways in spinal cord injury: Implications for the immune regulation
Neurobiol Dis. 2024 Apr 11:106500. doi: 10.1016/j.nbd.2024.106500. Online ahead of print.ABSTRACTSpinal Cord Injury (SCI) disrupts critical autonomic pathways responsible for the regulation of the immune function. Consequently, individuals with SCI often exhibit a spectrum of immune dysfunctions ranging from the development of damaging pro-inflammatory responses to severe immunosuppression. Thus, it is imperative to gain a more comprehensive understanding of the extent and mechanisms through which SCI-induced autonomic dysfunction influences the immune response. In this review, we provide an overview of the anatomical orga...
Source: Neurobiology of Disease - April 13, 2024 Category: Neurology Authors: Maria M Moura Andreia Monteiro Ant ónio J Salgado Nuno A Silva Susana Monteiro Source Type: research
Combining Fecal 16S rRNA Sequencing and Spinal Cord Metabolomics analysis to explain the modulatory effect of PPAR α on Neuropathic Pain
CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 13, 2024 Category: Neurology Authors: Zi-Jun Wu Yu-Ying Zhao Shu-Jing Hao Bei-Bei Dong Yu-Xin Zheng Bin Liu Jing Li Source Type: research
