From paralysis to possibility: an unexpected awakening [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join us as we sit down with Olivia Ong, a pain and rehabilitation medicine physician based in Australia, as she opens up about her incredible journey of resilience and self-discovery. In 2008, Olivia experienced a traumatic spinal cord injury that left
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From paralysis to possibility: an unexpected awakening [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 4, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Orthopedics Source Type: blogs
Higher Risk of Myocardial Infarction, Heart Failure, and Atrial Fibrillation Noted After Spinal Cord Injury
There are several factors which increase the risk of cardiovascular disease in survivors of spinal cord injury. They have a greater prevalence of obesity, dyslipidemia, metabolic syndrome and diabetes mellitus. Energy expenditure is lesser both due to lack of motor function and lack of opportunities to engage in physical activity. Autonomic dysfunction caused by spinal cord injury is associated with abnormalities in blood pressure, heart rate variability, arrhythmias and blunted cardiovascular response to exercise which can limit the capacity to perform physical activity [1].
A recent large study from Korea compared over 5...
Source: Cardiophile MD - February 27, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
My spinal cord injury story from physician to patient, and how I rebuilt my nervous system
t took a traumatic spinal cord injury in 2008 to transform my life. The experience was a radical awakening. I was told that I would never walk again. On one fine spring day in 2008, my life changed forever. I was walking to work when I was hit by a car at high speed. My
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My spinal cord injury story from physician to patient, and how I rebuilt my nervous system originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 26, 2024 Category: General Medicine Authors: Dr. Olivia Ong Tags: Physician Orthopedics Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
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Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MITF in the Regulation of Schwann Cell Nerve Repair Activity
The peripheral nervous system is far more capable of self-repair than the central nervous system. Nonetheless, nerve damage typically results in far less functional regeneration than is the case for other tissues. The research community is thus interested in finding ways to enhance existing repair processes. Here, researchers investigate a portion of the regulatory mechanisms that control the activity of Schwann cells in nerve repair, in search of targets for drug development programs aimed at enhancing regeneration of nerve damage, both in the peripheral nervous system, and also potentially in the central nervous system.
...
Source: Fight Aging! - December 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men.
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Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis
https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/
Neurogenesis is the process by which new neurons are created by neural stem c...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Unpalatable truths about pain
Recently I read a blog post about the way “Explain pain” had landed with a group of people in the general public. The point being made was that people found the ideas presented unpalatable. They didn’t agree with the points and they thought the ideas were dismissive of their experience.
Now I am a critic of any recipe-based approach to helping people. I am especially a critic of clinicians using something they’ve picked up on a weekend course, or out of a book, being applied holus bolus to an individual without nuance. There have been outrageous claims made about the effectiveness of giving some...
Source: HealthSkills Weblog - June 11, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Pain conditions Professional topics biopsychosocial pain management Therapeutic approaches Source Type: blogs
In an Ideal World, How Much Would We Spend on Health Care?
BY BEN WHEATLEY
We have heard it said before, and it is no longer shocking to say, that in 2021 the United States spent $4.3 trillion on health care. To put this gaudy number in some perspective, we measure it as a share of our economy and report that health care comprised 18.3% of our gross domestic product. CMS projects that health care will approach 20% of GDP in coming years—one-fifth of everything we buy and sell in this country.
In a recent report, the Health Affairs Council on Health Care Spending and Value said that “it is unclear what percentage of GDP would represent the ideal level to devote to h...
Source: The Health Care Blog - May 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health care spending medical debt Patent Source Type: blogs
In an Ideal World, How Much Would We Spend on Health Care? – Part 1
BY BEN WHEATLEY
We have heard it said before, and it is no longer shocking to say, that in 2021 the United States spent $4.3 trillion on health care. To put this gaudy number in some perspective, we measure it as a share of our economy and report that health care comprised 18.3% of our gross domestic product. CMS projects that health care will approach 20% of GDP in coming years—one-fifth of everything we buy and sell in this country.
In a recent report, the Health Affairs Council on Health Care Spending and Value said that “it is unclear what percentage of GDP would represent the ideal level to devote to healt...
Source: The Health Care Blog - May 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Ben Wheatley Health care spending medical debt Patent Source Type: blogs
Bonus Features – April 9, 2023 – 63% of RCM departments face staffing shortages, small Stanford study shows 90% of GPT answers in clinical setting are “ generally safe, ” and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job.
Research and Surveys
Stanford Health Care tested GPT-3.5 and GPT-4 models with 64 general clinical questions and compared the output of the models to consultation reports. Researchers found that more than 90% of GPT-3.5 and GPT...
Source: EMR and HIPAA - April 9, 2023 Category: Information Technology Authors: Brian Eastwood Tags: AI/Machine Learning Healthcare IT Revenue Cycle Management 4medica Addison Care Andrew Robinson Butterfly Network CenTrak ChatGPT CORL Corl Cleared Cost Plus Drugs CWH Advisors eClinicalWorks eCW Electronic Caregiver GPT-4 Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in thi...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Foobaw and more
Let me start with Damar Hamlin. His physicians haven ' t said anything publicly about what happened to him, but there are basically two possibilities. First, it is obviously uncommon but not unheard of for apparently healthy athletes to suffer cardiac arrest during exertion. This happened to Boston Celtics star Reggie Lewis. I happened to be in Boston Garden watching the first round playoff game against the Charlotte Hornets on April 29, 1993 when Lewis collapsed. All of the spectators were baffled about what had happened. Doctors at New England Baptist Hospital later diagnosed him with a heart abnormality...
Source: Stayin' Alive - January 6, 2023 Category: American Health Source Type: blogs
Age-Related Neuroinflammation and the Development of Neurodegenerative Conditions
The research community now considers chronic inflammation in brain tissue to be an important aspect of the development of neurodegenerative conditions. Unresolved inflammatory signaling is disruptive of tissue structure and function. With age, a state of chronic inflammation arises due to the presence of senescent cells, the reaction of the innate immune system to debris from stressed cells and metabolic waste such as protein aggregates, persistent viral infection, and a range of other contributing mechanisms. Therapies - such as senolytic treatments to clear senescent cells - that can suppress excess inflammation without ...
Source: Fight Aging! - January 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
