Fight Aging! Newsletter, November 2nd 2020
In conclusion, the circulating antibody repertoire has increased binding to thousands of peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention. The immune age has the potential for wide-spread use in clinical and consumer settings.
In Vivo Reprogramming Improves Cognitive Function in Old Mice
https://www.fightaging.org/archives/2020/10/in-vivo-reprogramming-improves-cognitive-function-in-old-mi...
Source: Fight Aging! - November 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Adjusting Glial Cell Behavior to Promote Axon Regrowth
One of the reasons why injuries to the nervous system are poorly regenerated at best is that the regrowth of axons, long connections between neurons, is hindered by scarring. The formation of neural tissue scarring is mediated by glial cells such as astrocytes. Researchers here demonstrate that it is in principle possible to adjust the behavior of these cells in order to reduce scar formation and promote successful axon regrowth following injury.
Glial cells carry out a variety of support and maintenance functions, and one type in particular - the astrocytic glial cell - has the unique ability to form scar tissue ...
Source: Fight Aging! - October 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 7th 2020
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - September 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Better Chondroitinase ABC to Break Down Nerve Tissue Scarring
Researchers here report on their successful redesign of the chondroitinase ABC enzyme, capable of degrading a form of scarring that forms following nervous system injury. This scarring inhibits regrowth of nerves, and thus suppressing or removing it may be beneficial. Chondroitinase ABC achieves this goal to some degree, but is impractical to use because of its instability in the body. This redesign may have improved stability to a large enough degree to make the enzyme a practical basis for therapies that improve nerve regrowth.
One of the major challenges to healing after the kind of nerve injury resulting from ...
Source: Fight Aging! - September 1, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Elon Musk ’s Neuralink Shares More About Its Implantable Brain Stimulator
Neuralink, one of Elon Musk’s newest ventures, was founded in 2016 but little has been known about the startup other than that it would somehow actualize Musk’s vision of a revolutionary implantable brain device. During a webcast last week, Musk and his team unveiled a bit more about what the company has been up to, including a live demo involving a trio of pigs.
The Neuralink implant, known as the “Link,” is essentially a miniaturized version of a deep brain stimulator. It’s a coin-sized device with a bundle of tiny wires, each five times thinner than a strand of human hair, protrudin...
Source: Medgadget - August 31, 2020 Category: Medical Devices Authors: Scott Jung Tags: Neurology Neurosurgery Source Type: blogs
Fight Aging! Newsletter, August 31st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 30, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Debate: Will brain-computer interfaces replace smartphones and other “mediating” devices?
The Fifth Industrial Revolution: where mind meets machine (The National):
The Fifth Industrial Revolution will make that connection closer and seamless, and will feel unmediated. The smart device onto which we tap and into which we speak will disappear. Brain-computer interfaces will replace them…Can we connect our brains – and our minds – to machines? The short answer is yes, and we have done so for some time. The longer answer is more complicated, but more interesting.
Until a few years ago, machines were connected to the brain and the nervous system principally for medical purposes – for example, to treat Parki...
Source: SharpBrains - August 17, 2020 Category: Neuroscience Authors: SharpBrains Tags: Cognitive Neuroscience Health & Wellness Technology -google Amazon brain-computer interface Brain-Computer Interfaces Ctrl-labs Facebook Fifth Industrial Revolution Fourth Industrial Revolution Kernel Neuralink Source Type: blogs
Nihon Kohden Releases Video Laryngoscope in U.S. for Faster Intubation During COVID
Critical care facilities around the world are on the front lines of the ongoing COVID-19 pandemic. Intubation is necessary to maintain many critical patients in the ICU, but too often obtaining an airway proves to be challenging. In some patients, intubation can take over a minute or more, potentially leading to serious consequences. Now, Nihon Kohden is launching its NK AWS-S200 video laryngoscope in the United States, marketed under the Pentax brand outside the U.S., that is designed to achieve intubation faster and on the first try. Moreover, the company claims that the device “can help protect clinicians while in...
Source: Medgadget - July 31, 2020 Category: Medical Devices Authors: Medgadget Editors Tags: Anesthesiology Critical Care Emergency Medicine ENT Public Health Surgery Source Type: blogs
Secondary gain: really?
One of my most popular posts ever is one I wrote many years ago on malingering. Secondary gain, like malingering or symptom magnification is one of those terms used by people who don’t live with persistent pain, and commonly used when a person with pain doesn’t seem to be progressing “as expected”. The term is an old one, originating in the psychoanalytic literature, brought into compensation and insurance environments but never really examined (Fishbain, Rosomoff, Cutler & Rosomoff, 1995) until well after it had become a popular label.
Freud first identified the potential for gains from bei...
Source: HealthSkills Weblog - July 12, 2020 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Chronic pain Professional topics Research malingering secondary gain stigma Source Type: blogs
Go-2 Spinal Stimulator Helps Return Leg Function: Interview with Jan Öhrström, Chairman of the Board, GTX Medical
GTX Medical, a medtech company with offices in The Netherlands and Switzerland, has announced that it received Breakthrough Device Designation for the Go-2 system, an implant that provides targeted epidural spinal stimulation therapy for patients with spinal cord injuries. The device aims to allow such patients to regain leg motor function and neurological control.
At present, patients with lower limb paralysis caused by traumatic spinal cord injuries have limited options in terms of regaining substantial functional recovery. The Go-2 systems aims to change this for patients with a sufficient number of remaining spinal ...
Source: Medgadget - June 25, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Neurosurgery Rehab Source Type: blogs
Befriending My Veteran Health Partner
By Linda Nguyen When I began medical school, I signed up to volunteer with Veteran Health Partners (VHP), an organization that pairs medical students with veterans in the Recreational Control Facility (RCF) of the local Veteran Affairs (VA) Hospital. Veterans in the RCF unit have conditions ranging from spinal cord injuries to paraplegia, many of […] (Source: blog.bioethics.net)
Source: blog.bioethics.net - June 24, 2020 Category: Medical Ethics Authors: reflectivemeded Tags: Health Care syndicated Uncategorized Source Type: blogs
The intricacies of working as a doctor with a spinal cord injury
I work as a resident in Australia’s busiest emergency department. Well, it was the busiest at a recent count anyway. The department is housed in the city of Gold Coast. The city sprawls across a beautiful stretch of beach. When I wake up, I turn my head to see the sun hanging out over the […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - June 11, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/dinesh-palipana" rel="tag" > Dr. Dinesh Palipana < /a > < /span > Tags: Physician Emergency Medicine Source Type: blogs
Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation.
Lin28 as a Target for Nerve Regeneration
https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondr...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lin28 as a Target for Nerve Regeneration
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondrial function, thus providing additional energy for cellular growth and replication. Researchers here employ a viral vector to deliver Lin28 to mice, which is a first step on the long road towards clinical applications. Practical therapies remain years in the future, however.
"Our findings show that Lin28 is a major regulator of...
Source: Fight Aging! - May 18, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Podcast: Is There a Link Between Physical and Mental Health?
What does physical pain have to do with depression, and vice versa? On today’s Psych Central Podcast, our guest, Dr. Jack Stern, a board-certified neurosurgeon specializing in spinal surgery, explains the psychology of pain and how the two are inextricably linked. Dr. Stern describes how pain can lead to depression and how depression can intensify physical pain.
We also find out why opioids don’t work for chronic pain, and how past pain affects current pain. Join us for an in-depth discussion on physical pain and mental health.
SUBSCRIBE & REVIEW
Guest information for ‘Dr. Jack Stern- Chronic Pain’ Podcast ...
Source: World of Psychology - May 14, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Chronic Pain Depression Disorders General Interview Mental Health and Wellness Podcast Psychology The Psych Central Show Source Type: blogs
