Wogonoside alleviates microglia-mediated neuroinflammation via TLR4/MyD88/NF- κB signaling axis after spinal cord injury
This study employed in silico, in vitro, and in vivo methodologies to investigate the impact of WG on microglia-mediated neuroinflammation after SCI. In the in silico experiment, we identified 15 potential target genes of WG associated with SCI. These genes were linked to the regulation of inflammatory response and immune defense. Molecular docking maps revealed toll-like receptor 4 as a molecular target for WG, demonstrating binding through a hydrogen bond (Lys263, Ser120). In lipopolysaccharide-stimulated BV2 cells and SCI mice, WG significantly attenuated microglial activation and facilitated a phenotype shift from M1 t...
Source: European Journal of Pharmacology - April 18, 2024 Category: Drugs & Pharmacology Authors: Ruyi Zhu Yaling Zhang Weitai He Yanan Sun Xin Zhao Yaping Yan Qian Zhang Source Type: research
Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord
This study aimed to elucidate the cellular and molecular mechanisms underlying the functional changes in foamy Mϕ and their potential implications for SCI. Contusion at T10 level of the spinal cord was induced using a New York University (NYU) impactor (5 g rod from a height of 6.25 mm) in male mice. ABCA1, an ATP-binding cassette transporter expressed by Mϕ, plays a crucial role in lipid efflux from foamy cells. We observed that foamy Mϕ lacking ABCA1 exhibited increased lipid accumulation and a higher presence of lipid-accumulated foamy Mϕ as well as elevated pro-inflammatory response in vitro and in injured spinal c...
Source: Brain, Behavior, and Immunity - April 18, 2024 Category: Neurology Authors: Xi Wang Zhijian Cheng Wenjiao Tai Mingjun Shi Maryam Ayazi Yang Liu Li Sun Caiyong Yu Zhongmin Fan Bin Guo Xijing He Dongming Sun Wise Young Yi Ren Source Type: research
Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway
This study showed that taurine significantly ameliorated axonal damage of spinal cord (SC), based on morphological and functional analyses, in a rat model of DN induced by streptozotocin (STZ). Taurine was also found to induce neurite outgrowth in cultured cerebral cortex neurons with high glucose exposure. Moreover, taurine up-regulated the expression of nerve growth factor (NGF) and neurite outgrowth relative protein GAP-43 in rat DN model and cultured cortical neurons/VSC4.1 cells. Besides, taurine increased the activating phosphorylation signals of TrkA, Akt, and mTOR. Mechanistically, the neuroprotection by taurine wa...
Source: Amino Acids - April 18, 2024 Category: Biochemistry Authors: Yachen Wang Bihu Gao Xiaochi Chen Xiaoxia Shi Shuangyue Li Qing Zhang Cong Zhang Fengyuan Piao Source Type: research
Onabotulinum toxin A improves neurogenic detrusor overactivity following spinal cord injury: a systematic review and meta-analysis
Spinal Cord, Published online: 18 April 2024; doi:10.1038/s41393-024-00992-9Onabotulinum toxin A improves neurogenic detrusor overactivity following spinal cord injury: a systematic review and meta-analysis (Source: Spinal Cord)
Source: Spinal Cord - April 18, 2024 Category: Research Authors: Saeed Vaheb Yousef Mokary Hamed Ghoshouni Omid Mirmosayyeb Elham Moases Ghaffary Vahid Shaygannejad Mohammad Yazdan Panah Source Type: research
Cardiorespiratory Responses to Acute Intermittent Hypoxia in Humans With Chronic Spinal Cord Injury
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 18, 2024 Category: Neurology Authors: Joseph F. Welch Alicia K. Vose Kate Cavka Gina Brunetti Louis A. DeMark Hannah Snyder Clayton N. Wauneka Geneva Tonuzi Jayakrishnan Nair Gordon S. Mitchell Emily J. Fox Source Type: research
Elevated microRNA-214-3p level ameliorates neuroinflammation after spinal cord ischemia-reperfusion injury by inhibiting Nmb/Cav3.2 pathway
CONCLUSIONS: Nmb protein levels positively correlated with Cav3.2 expression in SCII rats. Upregulating miR-214-3p ameliorated hind-limb motor function and protected against neuroinflammation via inhibiting the aberrant Nmb/Cav3.2 interactions and downstream IL-1β release. These findings provide novel therapeutic targets for clinical prevention and treatment of SCII.PMID:38631219 | DOI:10.1016/j.intimp.2024.112031 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Guo-Qiang Xia Miao Xu Cong Sun Zai-Li Zhang Xiao-Qian Li Source Type: research
Invasive neurostimulation in neuro-urology: state of the art
Aktuelle Urol. 2024 Apr 17. doi: 10.1055/a-2261-4792. Online ahead of print.ABSTRACTModulation or stimulation of the nerves supplying the lower urinary tract is a possible treatment option for dysfunction of the lower urinary tract, pelvic floor and rectum if conservative or minimally invasive treatment approaches fail. This overview shows the possibilities and limitations of sacral neuromodulation, sacral deafferentation with sacral anterior root stimulation and conus deafferentation.Sacral neuromodulation (SNM) is a procedure for the treatment of refractory pelvic floor dysfunction of various origins (idiopathic, neuroge...
Source: Aktuelle Urologie - April 17, 2024 Category: Urology & Nephrology Authors: Ines Kurze Ralf B öthig Arndt van Ophoven Source Type: research
Elevated microRNA-214-3p level ameliorates neuroinflammation after spinal cord ischemia-reperfusion injury by inhibiting Nmb/Cav3.2 pathway
CONCLUSIONS: Nmb protein levels positively correlated with Cav3.2 expression in SCII rats. Upregulating miR-214-3p ameliorated hind-limb motor function and protected against neuroinflammation via inhibiting the aberrant Nmb/Cav3.2 interactions and downstream IL-1β release. These findings provide novel therapeutic targets for clinical prevention and treatment of SCII.PMID:38631219 | DOI:10.1016/j.intimp.2024.112031 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 17, 2024 Category: Allergy & Immunology Authors: Guo-Qiang Xia Miao Xu Cong Sun Zai-Li Zhang Xiao-Qian Li Source Type: research
Invasive neurostimulation in neuro-urology: state of the art
Aktuelle Urol. 2024 Apr 17. doi: 10.1055/a-2261-4792. Online ahead of print.ABSTRACTModulation or stimulation of the nerves supplying the lower urinary tract is a possible treatment option for dysfunction of the lower urinary tract, pelvic floor and rectum if conservative or minimally invasive treatment approaches fail. This overview shows the possibilities and limitations of sacral neuromodulation, sacral deafferentation with sacral anterior root stimulation and conus deafferentation.Sacral neuromodulation (SNM) is a procedure for the treatment of refractory pelvic floor dysfunction of various origins (idiopathic, neuroge...
Source: Aktuelle Urologie - April 17, 2024 Category: Urology & Nephrology Authors: Ines Kurze Ralf B öthig Arndt van Ophoven Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
An improved method for generating human spinal cord neural stem cells
Exp Neurol. 2024 Apr 13:114779. doi: 10.1016/j.expneurol.2024.114779. Online ahead of print.ABSTRACTNeural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently reported that neural stem cells must be driven to a spinal cord fate to optimize host axonal regeneration into sites of implantation in the injured spinal cord, where they subsequently form neural relays across the lesion that support significant functional improvement. We also reported methods of deriving and culturing human spinal cord neural stem cells derived from embr...
Source: Experimental Neurology - April 15, 2024 Category: Neurology Authors: Y Li H Kumamaru T Vokes A Tran C Shevinsky L Graham K Archuleta K Limon P Lu A Blesch M H Tuszynski J H Brock Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
An improved method for generating human spinal cord neural stem cells
Exp Neurol. 2024 Apr 15;376:114779. doi: 10.1016/j.expneurol.2024.114779. Online ahead of print.ABSTRACTNeural stem cells have exhibited efficacy in pre-clinical models of spinal cord injury (SCI) and are on a translational path to human testing. We recently reported that neural stem cells must be driven to a spinal cord fate to optimize host axonal regeneration into sites of implantation in the injured spinal cord, where they subsequently form neural relays across the lesion that support significant functional improvement. We also reported methods of deriving and culturing human spinal cord neural stem cells derived from ...
Source: Experimental Neurology - April 15, 2024 Category: Neurology Authors: Y Li H Kumamaru T J Vokes A N Tran C A Shevinsky L Graham K Archuleta K R Limon P Lu A Blesch M H Tuszynski J H Brock Source Type: research
Low-frequency electrically induced exercise after spinal cord injury: Physiologic challenge to skeletal muscle and feasibility for long-term use
CONCLUSION: The 3 Hz stimulation offered the greatest physiological challenge and was perceived as more acceptable for long term use among people with SCI.PMID:38619192 | DOI:10.1080/10790268.2024.2338295 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 15, 2024 Category: Orthopaedics Authors: Michael A Petrie Shauna Dudley-Javoroski Kristin A Johnson Jinhyun Lee Olga Dubey Richard K Shields Source Type: research
