Which patients do we need to consider augmentation of muscle active potentials regarding transcranial electrical stimulation motor-evoked potentials monitoring before spine surgery?
Intraoperative neurophysiological monitoring (IONM) is important to prevent spinal cord or nerve root injuries during spinal surgery. Among the various modalities, transcranial electrical stimulation motor-evoked potentials (Tc-MEPs) have been widely used for IONM to assess motor pathway damage [1,2]. However, the amplitudes of compound muscle action potentials (CMAPs) can be suppressed by anesthetics and neuromuscular blockers [2,3]. Furthermore, patient-related factors such as preoperative motor deficits, age, presence of a lesion in the spinal cord, and endogenous diseases may also affect CMAPs [4 –7]. (Source: The Spine Journal)
Source: The Spine Journal - April 26, 2024 Category: Orthopaedics Authors: Takahiro Mui, Hideki Shigematsu, Tsunenori Takatani, Masaki Ikejiri, Sachiko Kawasaki, Hironobu Hayashi, Masahiko Kawaguchi, Yasuhito Tanaka Tags: Clinical Study Source Type: research
Macrophage: A key player in neuropathic pain
Int Rev Immunol. 2024 Apr 25:1-14. doi: 10.1080/08830185.2024.2344170. Online ahead of print.ABSTRACTResearch on the relationship between macrophages and neuropathic pain has flourished in the past two decades. It has long been believed that macrophages are strong immune effector cells that play well-established roles in tissue homeostasis and lesions, such as promoting the initiation and progression of tissue injury and improving wound healing and tissue remodeling in a variety of pathogenesis-related diseases. They are also heterogeneous and versatile cells that can switch phenotypically/functionally in response to the m...
Source: International Reviews of Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Ying Ye Hao Cheng Yan Wang Yan Sun Li-Dong Zhang Jun Tang Source Type: research
Differential relationships between physical activity and pain phenotypes in individuals with spinal cord injury
CONCLUSION: Differential relationships exist between pain phenotypes and MVPA in individuals with SCI. Pain location differed between the subgroups of nociceptive pain, which we presume may indicate the presence of nociplastic pain in some individuals. These results may contribute to the advancement of personalized pain management by targeting non-pharmacological interventions for specific pain phenotypes.Trial registration: ClinicalTrials.gov identifier: NCT05236933..PMID:38661677 | DOI:10.1080/10790268.2024.2344315 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 25, 2024 Category: Orthopaedics Authors: Alexandra Canori Donna L Coffman W Geoffrey Wright Margaret A Finley Shivayogi V Hiremath Source Type: research
Combination use of human menstrual blood stem cell- derived exosomes and hyperbaric oxygen therapy, synergistically promote recovery after spinal cord injury in rats
Tissue Cell. 2024 Apr 16;88:102378. doi: 10.1016/j.tice.2024.102378. Online ahead of print.ABSTRACTTraumatic spinal cord injury (TSCI) is one of the catastrophic events in the nervous system that leads to the loss of sensory and motor function of the spinal cord at the site of injury. Considering that several factors such as apoptosis, inflammation, and oxidative stress play a role in the spread of damage caused by trauma, therefore, the treatment should also be based on multifactorial approaches. Currently, we investigated the effects of human menstrual blood stem cells (MenSCs)-derived exosomes in combination with hyperb...
Source: Tissue and Cell - April 25, 2024 Category: Cytology Authors: Ahmed Hjazi Abdullah Alghamdi Ghfren S Aloraini Mohammed A Alshehri Meshari A Alsuwat Abdullah Albelasi Reham M Mashat Mohammed Alissa Source Type: research
Macrophage: A key player in neuropathic pain
Int Rev Immunol. 2024 Apr 25:1-14. doi: 10.1080/08830185.2024.2344170. Online ahead of print.ABSTRACTResearch on the relationship between macrophages and neuropathic pain has flourished in the past two decades. It has long been believed that macrophages are strong immune effector cells that play well-established roles in tissue homeostasis and lesions, such as promoting the initiation and progression of tissue injury and improving wound healing and tissue remodeling in a variety of pathogenesis-related diseases. They are also heterogeneous and versatile cells that can switch phenotypically/functionally in response to the m...
Source: International Reviews of Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Ying Ye Hao Cheng Yan Wang Yan Sun Li-Dong Zhang Jun Tang Source Type: research
Differential relationships between physical activity and pain phenotypes in individuals with spinal cord injury
CONCLUSION: Differential relationships exist between pain phenotypes and MVPA in individuals with SCI. Pain location differed between the subgroups of nociceptive pain, which we presume may indicate the presence of nociplastic pain in some individuals. These results may contribute to the advancement of personalized pain management by targeting non-pharmacological interventions for specific pain phenotypes.Trial registration: ClinicalTrials.gov identifier: NCT05236933..PMID:38661677 | DOI:10.1080/10790268.2024.2344315 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 25, 2024 Category: Orthopaedics Authors: Alexandra Canori Donna L Coffman W Geoffrey Wright Margaret A Finley Shivayogi V Hiremath Source Type: research
Combination use of human menstrual blood stem cell- derived exosomes and hyperbaric oxygen therapy, synergistically promote recovery after spinal cord injury in rats
Tissue Cell. 2024 Apr 16;88:102378. doi: 10.1016/j.tice.2024.102378. Online ahead of print.ABSTRACTTraumatic spinal cord injury (TSCI) is one of the catastrophic events in the nervous system that leads to the loss of sensory and motor function of the spinal cord at the site of injury. Considering that several factors such as apoptosis, inflammation, and oxidative stress play a role in the spread of damage caused by trauma, therefore, the treatment should also be based on multifactorial approaches. Currently, we investigated the effects of human menstrual blood stem cells (MenSCs)-derived exosomes in combination with hyperb...
Source: Tissue and Cell - April 25, 2024 Category: Cytology Authors: Ahmed Hjazi Abdullah Alghamdi Ghfren S Aloraini Mohammed A Alshehri Meshari A Alsuwat Abdullah Albelasi Reham M Mashat Mohammed Alissa Source Type: research
Macrophage: A key player in neuropathic pain
Int Rev Immunol. 2024 Apr 25:1-14. doi: 10.1080/08830185.2024.2344170. Online ahead of print.ABSTRACTResearch on the relationship between macrophages and neuropathic pain has flourished in the past two decades. It has long been believed that macrophages are strong immune effector cells that play well-established roles in tissue homeostasis and lesions, such as promoting the initiation and progression of tissue injury and improving wound healing and tissue remodeling in a variety of pathogenesis-related diseases. They are also heterogeneous and versatile cells that can switch phenotypically/functionally in response to the m...
Source: International Reviews of Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Ying Ye Hao Cheng Yan Wang Yan Sun Li-Dong Zhang Jun Tang Source Type: research
Differential relationships between physical activity and pain phenotypes in individuals with spinal cord injury
CONCLUSION: Differential relationships exist between pain phenotypes and MVPA in individuals with SCI. Pain location differed between the subgroups of nociceptive pain, which we presume may indicate the presence of nociplastic pain in some individuals. These results may contribute to the advancement of personalized pain management by targeting non-pharmacological interventions for specific pain phenotypes.Trial registration: ClinicalTrials.gov identifier: NCT05236933..PMID:38661677 | DOI:10.1080/10790268.2024.2344315 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 25, 2024 Category: Orthopaedics Authors: Alexandra Canori Donna L Coffman W Geoffrey Wright Margaret A Finley Shivayogi V Hiremath Source Type: research
Combination use of human menstrual blood stem cell- derived exosomes and hyperbaric oxygen therapy, synergistically promote recovery after spinal cord injury in rats
Tissue Cell. 2024 Apr 16;88:102378. doi: 10.1016/j.tice.2024.102378. Online ahead of print.ABSTRACTTraumatic spinal cord injury (TSCI) is one of the catastrophic events in the nervous system that leads to the loss of sensory and motor function of the spinal cord at the site of injury. Considering that several factors such as apoptosis, inflammation, and oxidative stress play a role in the spread of damage caused by trauma, therefore, the treatment should also be based on multifactorial approaches. Currently, we investigated the effects of human menstrual blood stem cells (MenSCs)-derived exosomes in combination with hyperb...
Source: Tissue and Cell - April 25, 2024 Category: Cytology Authors: Ahmed Hjazi Abdullah Alghamdi Ghfren S Aloraini Mohammed A Alshehri Meshari A Alsuwat Abdullah Albelasi Reham M Mashat Mohammed Alissa Source Type: research
Macrophage: A key player in neuropathic pain
Int Rev Immunol. 2024 Apr 25:1-14. doi: 10.1080/08830185.2024.2344170. Online ahead of print.ABSTRACTResearch on the relationship between macrophages and neuropathic pain has flourished in the past two decades. It has long been believed that macrophages are strong immune effector cells that play well-established roles in tissue homeostasis and lesions, such as promoting the initiation and progression of tissue injury and improving wound healing and tissue remodeling in a variety of pathogenesis-related diseases. They are also heterogeneous and versatile cells that can switch phenotypically/functionally in response to the m...
Source: International Reviews of Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Ying Ye Hao Cheng Yan Wang Yan Sun Li-Dong Zhang Jun Tang Source Type: research
Differential relationships between physical activity and pain phenotypes in individuals with spinal cord injury
CONCLUSION: Differential relationships exist between pain phenotypes and MVPA in individuals with SCI. Pain location differed between the subgroups of nociceptive pain, which we presume may indicate the presence of nociplastic pain in some individuals. These results may contribute to the advancement of personalized pain management by targeting non-pharmacological interventions for specific pain phenotypes.Trial registration: ClinicalTrials.gov identifier: NCT05236933..PMID:38661677 | DOI:10.1080/10790268.2024.2344315 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 25, 2024 Category: Orthopaedics Authors: Alexandra Canori Donna L Coffman W Geoffrey Wright Margaret A Finley Shivayogi V Hiremath Source Type: research
Macrophage: A key player in neuropathic pain
Int Rev Immunol. 2024 Apr 25:1-14. doi: 10.1080/08830185.2024.2344170. Online ahead of print.ABSTRACTResearch on the relationship between macrophages and neuropathic pain has flourished in the past two decades. It has long been believed that macrophages are strong immune effector cells that play well-established roles in tissue homeostasis and lesions, such as promoting the initiation and progression of tissue injury and improving wound healing and tissue remodeling in a variety of pathogenesis-related diseases. They are also heterogeneous and versatile cells that can switch phenotypically/functionally in response to the m...
Source: International Reviews of Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Ying Ye Hao Cheng Yan Wang Yan Sun Li-Dong Zhang Jun Tang Source Type: research
Differential relationships between physical activity and pain phenotypes in individuals with spinal cord injury
CONCLUSION: Differential relationships exist between pain phenotypes and MVPA in individuals with SCI. Pain location differed between the subgroups of nociceptive pain, which we presume may indicate the presence of nociplastic pain in some individuals. These results may contribute to the advancement of personalized pain management by targeting non-pharmacological interventions for specific pain phenotypes.Trial registration: ClinicalTrials.gov identifier: NCT05236933..PMID:38661677 | DOI:10.1080/10790268.2024.2344315 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 25, 2024 Category: Orthopaedics Authors: Alexandra Canori Donna L Coffman W Geoffrey Wright Margaret A Finley Shivayogi V Hiremath Source Type: research
Reactive Oxygen Species ‐Responsive Composite Fibers Regulate Oxidative Metabolism through Internal and External Factors to Promote the Recovery of Nerve Function
Inspired by the pathological characteristics of excess ROS and depletion of neurotrophins after spinal cord injury, a composite fiber scaffold with spatiotemporal delivery for the efficient regulation of ROS and continuous supply of neurotrophins is developed in the study. The biomimetic composite fiber scaffold can promote the cascade reaction of neuronal autophagy metabolism, improve the local microenvironment, and help reconstruct neural networks. AbstractIt is challenging to sufficiently regulate endogenous neuronal reactive oxygen species (ROS) production, reduce neuronal apoptosis, and reconstruct neural networks und...
Source: Small - April 25, 2024 Category: Nanotechnology Authors: Hongyi Zhu,
Liang Zhou,
Jincheng Tang,
Yichang Xu,
Wei Wang,
Wenxiao Shi,
Ziang Li,
Lichen Zhang,
Zhouye Ding,
Kun Xi,
Yong Gu,
Liang Chen Tags: Research Article Source Type: research
